Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Candidate in Clinical Trials for the Treatment of Age-Related Macular Degeneration
Palanki, Moorthy S. S, Akiyama, Hideo, Campochiaro, Peter, Cao, Jianguo, Chow, Chun P, Dellamary, Luis, Doukas, John, Fine, Richard, Gritzen, Colleen, Hood, John D, Hu, Steven, Kachi, Shu, Kang, Xinshan, Klebansky, Boris, Kousba, Ahmed, Lohse, Dan, Mak, Chi Ching, Martin, Michael, McPherson, Andrew, Pathak, Ved P, Renick, Joel, Soll, Richard, Umeda, Naoyasu, Yee, Shiyin, Yokoi, Katsutoshi, Zeng, Binqi, Zhu, Hong, Noronha, Glenn
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Published in Journal of medicinal chemistry (27.03.2008)
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The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia
Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J., Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E., Cui, Daniel, Erickson, Caroline E., Tittley, Steven M., Penson, Alexander V., Knorr, Katherine, Stanley, Robert F., Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A., Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M., Bradley, Robert K., Abdel-Wahab, Omar
Published in Cancer cell (09.01.2023)
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Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
Wernig, Gerlinde, Kharas, Michael G., Okabe, Rachel, Moore, Sandra A., Leeman, Dena S., Cullen, Dana E., Gozo, Maricel, McDowell, Elizabeth P., Levine, Ross L., Doukas, John, Mak, Chi Ching, Noronha, Glenn, Martin, Michael, Ko, Yon D., Lee, Benjamin H., Soll, Richard M., Tefferi, Ayalew, Hood, John D., Gilliland, D. Gary
Published in Cancer cell (01.04.2008)
Published in Cancer cell (01.04.2008)
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피롤로[2,1-f][1,2,4]트리아진 및 그의 제조 및 용도
MARAKOVITS JOSEPH TIMOTHY, MITTAPALLI GOPI KUMAR, TURNER LEWIS DANIEL, EASTMAN BRIAN WALTER, KC SUNIL KUMAR, HOFILENA BRIAN JOSEPH, VAKITI RAMKRISHNA REDDY, MAK CHI CHING
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
Patent
Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays
Noronha, Glenn, Barrett, Kathy, Boccia, Antonio, Brodhag, Tessa, Cao, Jianguo, Chow, Chun P., Dneprovskaia, Elena, Doukas, John, Fine, Richard, Gong, Xianchang, Gritzen, Colleen, Gu, Hong, Hanna, Ehab, Hood, John D., Hu, Steven, Kang, Xinshan, Key, Jann, Klebansky, Boris, Kousba, Ahmed, Li, Ge, Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Shi, Feng, Soll, Richard, Splittgerber, Ute, Stoughton, Silva, Tang, Suhan, Yee, Shiyin, Zeng, Binqi, Zhao, Ningning, Zhu, Hong
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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The design and preliminary structure–activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes
Cao, Jianguo, Fine, Richard, Gritzen, Colleen, Hood, John, Kang, Xinshan, Klebansky, Boris, Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Noronha, Glenn, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Soll, Richard, Zeng, Binqi, Zhu, Hong
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Synthesis and Structure−Activity Relationship of Small-Molecule Malonyl Coenzyme A Decarboxylase Inhibitors
Cheng, Jie-Fei, Chen, Mi, Wallace, David, Tith, Souvothy, Haramura, Masayuki, Liu, Bin, Mak, Chi Ching, Arrhenius, Thomas, Reily, Sean, Brown, Steven, Thorn, Vicki, Harmon, Charles, Barr, Rick, Dyck, Jason R. B, Lopaschuk, Gary D, Nadzan, Alex M
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors
Noronha, Glenn, Barrett, Kathy, Cao, Jianguo, Dneprovskaia, Elena, Fine, Richard, Gong, Xianchang, Gritzen, Colleen, Hood, John, Kang, Xinshan, Klebansky, Boris, Li, G., Liao, W., Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Soll, Richard, Splittgerber, Ute, Wrasidlo, Wolfgang, Zeng, Binqi, Zhao, Ningning, Zhou, Y.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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A Strategy for the Assembly of Multiple Porphyrin Arrays Based on the Coordination Chemistry of Ru-Centered Porphyrin Pentamers
Mak, Chi Ching, Bampos, Nick, Darling, Scott L, Montalti, Marco, Prodi, Luca, Sanders, Jeremy K. M
Published in Journal of organic chemistry (29.06.2001)
Published in Journal of organic chemistry (29.06.2001)
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Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors
Cheng, Jie-Fei, Mak, Chi Ching, Huang, Yujin, Penuliar, Richard, Nishimoto, Masahiro, Zhang, Lin, Chen, Mi, Wallace, David, Arrhenius, Thomas, Chu, Donald, Yang, Guang, Barbosa, Miguel, Barr, Rick, Dyck, Jason R.B., Lopaschuk, Gary D., Nadzan, Alex M.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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5-헤테로아릴 치환된 인다졸-3-카복사미드 및 그의 제조 및 용도
MITTAPALLI GOPI KUMAR, EASTMAN BRIAN WALTER, CAO JIANGUO, CHIRUTA CHANDRAMOULI, KC SUNIL KUMAR, BOLLU VENKATAIAH, HOFILENA BRIAN JOSEPH, MAK CHI CHING
Year of Publication 06.11.2020
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Year of Publication 06.11.2020
Patent
Ru(II)-centred porphyrin pentamers as coordination building blocks for large porphyrin arrays
Mak, CC, Bampos, N, Sanders, JKM
Published in Chemical communications (Cambridge, England) (21.06.1999)
Published in Chemical communications (Cambridge, England) (21.06.1999)
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이소퀴놀린-3-일 카르복스아마이드 및 이의 제제와 용도
MITTAPALLI GOPI KUMAR, EASTMAN BRIAN WALTER, CAO JIANGUO, CHIRUTA CHANDRAMOULI, KC SUNIL KUMAR, BOLLU VENKATAIAH, MAK CHI CHING
Year of Publication 12.02.2019
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Year of Publication 12.02.2019
Patent
이소퀴놀린-3-일 카르복스아마이드 및 이의 제제와 용도
MARAKOVITS JOSEPH TIMOTHY, MITTAPALLI GOPI KUMAR, CAO JIANGUO, CHIRUTA CHANDRAMOULI, KC SUNIL KUMAR, HOFILENA BRIAN JOSEPH, MAK CHI CHING
Year of Publication 08.02.2019
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Year of Publication 08.02.2019
Patent