Biased Opioid Ligands
Faouzi, Abdelfattah, Varga, Balazs R, Majumdar, Susruta
Published in Molecules (Basel, Switzerland) (16.09.2020)
Published in Molecules (Basel, Switzerland) (16.09.2020)
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Journal Article
IUPHAR themed review: Opioid efficacy, bias, and selectivity
Ramos-Gonzalez, Nokomis, Paul, Barnali, Majumdar, Susruta
Published in Pharmacological research (01.11.2023)
Published in Pharmacological research (01.11.2023)
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Journal Article
Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
Kruegel, Andrew C, Gassaway, Madalee M, Kapoor, Abhijeet, Váradi, András, Majumdar, Susruta, Filizola, Marta, Javitch, Jonathan A, Sames, Dalibor
Published in Journal of the American Chemical Society (01.06.2016)
Published in Journal of the American Chemical Society (01.06.2016)
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Journal Article
Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles
Váradi, András, Palmer, Travis C, Notis Dardashti, Rebecca, Majumdar, Susruta
Published in Molecules (23.12.2015)
Published in Molecules (23.12.2015)
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Journal Article
Book Review
Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor
Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.
Published in Cell (11.01.2018)
Published in Cell (11.01.2018)
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Journal Article
Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy
Bhowmik, Srijita, Galeta, Juraj, Havel, Václav, Nelson, Melissa, Faouzi, Abdelfattah, Bechand, Benjamin, Ansonoff, Mike, Fiala, Tomas, Hunkele, Amanda, Kruegel, Andrew C, Pintar, John E, Majumdar, Susruta, Javitch, Jonathan A, Sames, Dalibor
Published in Nature communications (22.06.2021)
Published in Nature communications (22.06.2021)
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Journal Article
Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells
Stoeber, Miriam, Jullié, Damien, Li, Joy, Chakraborty, Soumen, Majumdar, Susruta, Lambert, Nevin A, Manglik, Aashish, von Zastrow, Mark
Published in eLife (25.02.2020)
Published in eLife (25.02.2020)
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Journal Article
Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal
Wilson, Lisa L., Chakraborty, Soumen, Eans, Shainnel O., Cirino, Thomas J., Stacy, Heather M., Simons, Chloe A., Uprety, Rajendra, Majumdar, Susruta, McLaughlin, Jay P.
Published in Cellular and molecular neurobiology (01.07.2021)
Published in Cellular and molecular neurobiology (01.07.2021)
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Journal Article
Oxidative Metabolism as a Modulator of Kratom’s Biological Actions
Chakraborty, Soumen, Uprety, Rajendra, Slocum, Samuel T, Irie, Takeshi, Le Rouzic, Valerie, Li, Xiaohai, Wilson, Lisa L, Scouller, Brittany, Alder, Amy F, Kruegel, Andrew C, Ansonoff, Michael, Varadi, Andras, Eans, Shainnel O, Hunkele, Amanda, Allaoa, Abdullah, Kalra, Sanjay, Xu, Jin, Pan, Ying Xian, Pintar, John, Kivell, Bronwyn M, Pasternak, Gavril W, Cameron, Michael D, McLaughlin, Jay P, Sames, Dalibor, Majumdar, Susruta
Published in Journal of medicinal chemistry (25.11.2021)
Published in Journal of medicinal chemistry (25.11.2021)
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Journal Article
Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain
Grinnell, Steven G., Uprety, Rajendra, Varadi, Andras, Subrath, Joan, Hunkele, Amanda, Pan, Ying Xian, Pasternak, Gavril W., Majumdar, Susruta
Published in Cellular and molecular neurobiology (01.07.2021)
Published in Cellular and molecular neurobiology (01.07.2021)
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Journal Article
7‑Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects
Kruegel, Andrew C, Uprety, Rajendra, Grinnell, Steven G, Langreck, Cory, Pekarskaya, Elizabeth A, Le Rouzic, Valerie, Ansonoff, Michael, Gassaway, Madalee M, Pintar, John E, Pasternak, Gavril W, Javitch, Jonathan A, Majumdar, Susruta, Sames, Dalibor
Published in ACS central science (26.06.2019)
Published in ACS central science (26.06.2019)
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Journal Article
Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor
Muratspahić, Edin, Deibler, Kristine, Han, Jianming, Tomašević, Nataša, Jadhav, Kirtikumar B, Olivé-Marti, Aina-Leonor, Hochrainer, Nadine, Hellinger, Roland, Koehbach, Johannes, Fay, Jonathan F, Rahman, Mohammad Homaidur, Hegazy, Lamees, Craven, Timothy W, Varga, Balazs R, Bhardwaj, Gaurav, Appourchaux, Kevin, Majumdar, Susruta, Muttenthaler, Markus, Hosseinzadeh, Parisa, Craik, David J, Spetea, Mariana, Che, Tao, Baker, David, Gruber, Christian W
Published in Nature communications (06.12.2023)
Published in Nature communications (06.12.2023)
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Journal Article
Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
Majumdar, Susruta, Grinnell, Steven, Le Rouzic, Valerie, Burgman, Maxim, Polikar, Lisa, Ansonoff, Michael, Pintar, John, Pan, Ying-Xian, Pasternak, Gavril W
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
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Journal Article
Imaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([124I]IPAG)
Gangangari, Kishore K., Váradi, András, Majumdar, Susruta, Larson, Steven M., Pasternak, Gavril W., Pillarsetty, NagaVara Kishore
Published in Molecular imaging and biology (01.04.2020)
Published in Molecular imaging and biology (01.04.2020)
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Journal Article
Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
Uprety, Rajendra, Che, Tao, Zaidi, Saheem A, Grinnell, Steven G, Varga, Balázs R, Faouzi, Abdelfattah, Slocum, Samuel T, Allaoa, Abdullah, Varadi, András, Nelson, Melissa, Bernhard, Sarah M, Kulko, Elizaveta, Le Rouzic, Valerie, Eans, Shainnel O, Simons, Chloe A, Hunkele, Amanda, Subrath, Joan, Pan, Ying Xian, Javitch, Jonathan A, McLaughlin, Jay P, Roth, Bryan L, Pasternak, Gavril W, Katritch, Vsevolod, Majumdar, Susruta
Published in eLife (08.02.2021)
Published in eLife (08.02.2021)
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Journal Article
Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models
Havel, Václav, Kruegel, Andrew C, Bechand, Benjamin, McIntosh, Scot, Stallings, Leia, Hodges, Alana, Wulf, Madalee G, Nelson, Mel, Hunkele, Amanda, Ansonoff, Michael, Pintar, John E, Hwu, Christopher, Ople, Rohini S, Abi-Gerges, Najah, Zaidi, Saheem A, Katritch, Vsevolod, Yang, Mu, Javitch, Jonathan A, Majumdar, Susruta, Hemby, Scott E, Sames, Dalibor
Published in Nature communications (20.09.2024)
Published in Nature communications (20.09.2024)
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Journal Article
Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS
Marrone, Gina F., Grinnell, Steven G., Lu, Zhigang, Rossi, Grace C., Le Rouzic, Valerie, Xu, Jin, Majumdar, Susruta, Pan, Ying-Xian, Pasternak, Gavril W.
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (29.03.2016)
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Journal Article
Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder
Gutridge, Anna M., Chakraborty, Soumen, Varga, Balazs R., Rhoda, Elizabeth S., French, Alexander R., Blaine, Arryn T., Royer, Quinten H., Cui, Haoyue, Yuan, Jinling, Cassell, Robert J., Szabó, Márk, Majumdar, Susruta, van Rijn, Richard M.
Published in Frontiers in pharmacology (03.11.2021)
Published in Frontiers in pharmacology (03.11.2021)
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Journal Article
Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
Grinnell, Steven G., Ansonoff, Michael, Marrone, Gina F., Lu, Zhigang, Narayan, Ankita, Xu, Jin, Rossi, Grace, Majumdar, Susruta, Pan, Ying-Xian, Bassoni, Daniel L., Pintar, John, Pasternak, Gavril W.
Published in Synapse (New York, N.Y.) (01.10.2016)
Published in Synapse (New York, N.Y.) (01.10.2016)
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Journal Article
Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, OPRM1 : Insight into Complex Mu Opioid Actions
Liu, Shan, Kang, Wen-Jia, Abrimian, Anna, Xu, Jin, Cartegni, Luca, Majumdar, Susruta, Hesketh, Patrick, Bekker, Alex, Pan, Ying-Xian
Published in Biomolecules (Basel, Switzerland) (15.10.2021)
Published in Biomolecules (Basel, Switzerland) (15.10.2021)
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