Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
Benjamin, Don, Robay, Dimitri, Hindupur, Sravanth K., Pohlmann, Jens, Colombi, Marco, El-Shemerly, Mahmoud Y., Maira, Sauveur-Michel, Moroni, Christoph, Lane, Heidi A., Hall, Michael N.
Published in Cell reports (Cambridge) (11.12.2018)
Published in Cell reports (Cambridge) (11.12.2018)
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The Role of PTEN/Akt/PI3k Signaling in the Maintenance and Viability of Prostate Cancer Stem-Like Cell Populations
Dubrovska, Anna, Kim, Sungeun, Salamone, Richard J., Walker, John R., Maira, Sauveur-Michel, García-Echeverría, Carlos, Schultz, Peter G., Reddy, Venkateshwar A.
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
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Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor
Maira, Sauveur-Michel, Pecchi, Sabina, Huang, Alan, Burger, Matthew, Knapp, Mark, Sterker, Dario, Schnell, Christian, Guthy, Daniel, Nagel, Tobi, Wiesmann, Marion, Brachmann, Saskia, Fritsch, Christine, Dorsch, Marion, Chène, Patrick, Shoemaker, Kevin, De Pover, Alain, Menezes, Daniel, Martiny-Baron, Georg, Fabbro, Doriano, Wilson, Christopher J, Schlegel, Robert, Hofmann, Francesco, García-Echeverría, Carlos, Sellers, William R, Voliva, Charles F
Published in Molecular cancer therapeutics (01.02.2012)
Published in Molecular cancer therapeutics (01.02.2012)
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Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
Brachmann, Saskia M, Hofmann, Irmgard, Schnell, Christian, Fritsch, Christine, Wee, Susan, Lane, Heidi, Wang, Shaowen, Garcia-Echeverria, Carlos, Maira, Sauveur-Michel
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2009)
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Journal Article
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
Maira, Sauveur-Michel, Stauffer, Frédéric, Brueggen, Josef, Furet, Pascal, Schnell, Christian, Fritsch, Christine, Brachmann, Saskia, Chène, Patrick, De Pover, Alain, Schoemaker, Kevin, Fabbro, Doriano, Gabriel, Daniela, Simonen, Marjo, Murphy, Leon, Finan, Peter, Sellers, William, García-Echeverría, Carlos
Published in Molecular cancer therapeutics (01.07.2008)
Published in Molecular cancer therapeutics (01.07.2008)
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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
Cantley, Lewis C, Wong, Kwok-Kin, Engelman, Jeffrey A, Chen, Liang, Tan, Xiaohong, Crosby, Katherine, Guimaraes, Alexander R, Upadhyay, Rabi, Maira, Michel, McNamara, Kate, Perera, Samanthi A, Song, Youngchul, Chirieac, Lucian R, Kaur, Ramneet, Lightbown, Angela, Simendinger, Jessica, Li, Timothy, Padera, Robert F, García-Echeverría, Carlos, Weissleder, Ralph, Mahmood, Umar
Published in Nature medicine (01.12.2008)
Published in Nature medicine (01.12.2008)
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NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
Liu, Ta-Jen, Koul, Dimpy, LaFortune, Tiffany, Tiao, Ningyi, Shen, Rui Jun, Maira, Sauveur-Michel, Garcia-Echevrria, Carlos, Yung, W K Alfred
Published in Molecular cancer therapeutics (01.08.2009)
Published in Molecular cancer therapeutics (01.08.2009)
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Journal Article
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
Faber, Anthony C, Li, Danan, Song, YoungChul, Liang, Mei-Chih, Yeap, Beow Y, Bronson, Roderick T, Lifshits, Eugene, Chen, Zhao, Maira, Sauveur-Michel, García-Echeverría, Carlos, Wong, Kwok-Kin, Engelman, Jeffrey A
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Journal Article
Antitumor Activity of NVP-BKM120―A Selective Pan Class I PI3 Kinase Inhibitor Showed Differential Forms of Cell Death Based on p53 Status of Glioma Cells
KOUL, Dimpy, JUN FU, GARCIA-ECHEVRRIA, Carlos, MAIRA, Sauveur-Michel, ALFRED YUNG, W. K, RUIJUN SHEN, LAFORTUNE, Tiffany A, SHUZHEN WANG, NINGYI TIAO, KIM, Yong-Wan, LIU, Juinn-Lin, RAMNARIAN, Deepti, YING YUAN
Published in Clinical cancer research (01.01.2012)
Published in Clinical cancer research (01.01.2012)
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Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature
FOKAS, Emmanouil, JAE HONG IM, MUSCHEL, Ruth J, HILL, Sally, YAMEEN, Sabira, STRATFORD, Michael, BEECH, John, HACKL, Wolfgang, MAIRA, Sauveur-Michel, BEMHARD, Eric J, GILLIES MCKENNA, W
Published in Cancer research (Chicago, Ill.) (2012)
Published in Cancer research (Chicago, Ill.) (2012)
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Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia
CHAPUIS, Nicolas, TAMBURINI, Jerome, MAIRA, Sauveur-Michel, IFRAH, Norbert, DREYFUS, François, HERAULT, Olivier, LACOMBE, Catherine, MAYEUX, Patrick, BOUSCARY, Didier, GREEN, Alexa S, VIGNON, Christine, BARDET, Valerie, NEYRET, Aymeric, PANNETIER, Melanie, WILLEMS, Lise, PARK, Sophie, MACONE, Alexandre
Published in Clinical cancer research (15.11.2010)
Published in Clinical cancer research (15.11.2010)
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Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
Breuleux, Madlaina, Klopfenstein, Matthieu, Stephan, Christine, Doughty, Cheryl A, Barys, Louise, Maira, Saveur-Michel, Kwiatkowski, David, Lane, Heidi A
Published in Molecular cancer therapeutics (01.04.2009)
Published in Molecular cancer therapeutics (01.04.2009)
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Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
Carretero, Julian, Shimamura, Takeshi, Rikova, Klarisa, Jackson, Autumn L., Wilkerson, Matthew D., Borgman, Christa L., Buttarazzi, Matthew S., Sanofsky, Benjamin A., McNamara, Kate L., Brandstetter, Kathleyn A., Walton, Zandra E., Gu, Ting-Lei, Silva, Jeffrey C., Crosby, Katherine, Shapiro, Geoffrey I., Maira, Sauveur-Michel, Ji, Hongbin, Castrillon, Diego H., Kim, Carla F., García-Echeverría, Carlos, Bardeesy, Nabeel, Sharpless, Norman E., Hayes, Neil D., Kim, William Y., Engelman, Jeffrey A., Wong, Kwok-Kin
Published in Cancer cell (15.06.2010)
Published in Cancer cell (15.06.2010)
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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor
Lane, Heidi A, Wood, Jeanette M, McSheehy, Paul M J, Allegrini, Peter R, Boulay, Anne, Brueggen, Joseph, Littlewood-Evans, Amanda, Maira, Sauveur-Michel, Martiny-Baron, Georg, Schnell, Christian R, Sini, Patrizia, O'Reilly, Terence
Published in Clinical cancer research (01.03.2009)
Published in Clinical cancer research (01.03.2009)
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PI3K inhibitors for cancer treatment: where do we stand?
Maira, Sauveur-Michel, Stauffer, Frédéric, Schnell, Christian, García-Echeverría, Carlos
Published in Biochemical Society transactions (01.02.2009)
Published in Biochemical Society transactions (01.02.2009)
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Journal Article
NVP-BEZ235 as a New Therapeutic Option for Sarcomas
Manara, Maria C, Nicoletti, Giordano, Zambelli, Diana, Ventura, Selena, Guerzoni, Clara, Landuzzi, Lorena, Lollini, Pier-Luigi, Maira, Saveur-Michel, García-Echeverría, Carlos, Mercuri, Mario, Picci, Piero, Scotlandi, Katia
Published in Clinical cancer research (15.01.2010)
Published in Clinical cancer research (15.01.2010)
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Characterization of the mechanism of action of the pan class I PI3K inhibitor NVP-BKM120 across a broad range of concentrations
Brachmann, Saskia M, Kleylein-Sohn, Julia, Gaulis, Swann, Kauffmann, Audrey, Blommers, Marcel J J, Kazic-Legueux, Malika, Laborde, Laurent, Hattenberger, Marc, Stauffer, Fabian, Vaxelaire, Juliane, Romanet, Vincent, Henry, Chrystèle, Murakami, Masato, Guthy, Daniel Alexander, Sterker, Dario, Bergling, Sebastian, Wilson, Christopher, Brümmendorf, Thomas, Fritsch, Christine, Garcia-Echeverria, Carlos, Sellers, William R, Hofmann, Francesco, Maira, Sauveur-Michel
Published in Molecular cancer therapeutics (01.08.2012)
Published in Molecular cancer therapeutics (01.08.2012)
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Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
Schnell, Christian R, Stauffer, Frédéric, Allegrini, Peter R, O'Reilly, Terence, McSheehy, Paul M J, Dartois, Celine, Stumm, Michael, Cozens, Robert, Littlewood-Evans, Amanda, García-Echeverría, Carlos, Maira, Sauveur-Michel
Published in Cancer research (Chicago, Ill.) (15.08.2008)
Published in Cancer research (Chicago, Ill.) (15.08.2008)
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A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
HAILING CHENG, PIXU LIU, MYERS, Andrea P, CANTLEY, Lewis C, MILLS, Gordon B, ZHAO, Jean J, FAN ZHANG, ERBO XU, SYMONDS, Lynn, OHLSON, Carolynn E, BRONSON, Roderick T, MAIRA, Sauveur-Michel, DI TOMASO, Emmanuelle, JANE LI
Published in Cancer research (Chicago, Ill.) (01.01.2014)
Published in Cancer research (Chicago, Ill.) (01.01.2014)
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