4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-Ones Prevent the Transmission of Plasmodium falciparum to Anopheles freeborni
SAENZ, Fabián E, LACRUE, Alexis N, CROSS, R. Matthew, MAIGNAN, Jordany R, UDENZE, Kenneth O, MANETSCH, Roman, KYLE, Dennis E
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
Published in Antimicrobial Agents and Chemotherapy (01.12.2013)
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Journal Article
Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)‑Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies
Neelarapu, Raghupathi, Maignan, Jordany R, Lichorowic, Cynthia L, Monastyrskyi, Andrii, Mutka, Tina S, LaCrue, Alexis N, Blake, Lynn D, Casandra, Debora, Mashkouri, Sherwin, Burrows, Jeremy N, Willis, Paul A, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)‑Quinolones with Single Dose Cures
Monastyrskyi, Andrii, Brockmeyer, Fabian, LaCrue, Alexis N, Zhao, Yingzhao, Maher, Steven P, Maignan, Jordany R, Padin-Irizarry, Vivian, Sakhno, Yana I, Parvatkar, Prakash T, Asakawa, Ami H, Huang, Lili, Casandra, Debora, Mashkouri, Sherwin, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (27.05.2021)
Published in Journal of medicinal chemistry (27.05.2021)
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Journal Article
ICI 56,780 Optimization: Structure–Activity Relationship Studies of 7‑(2-Phenoxyethoxy)-4(1H)‑quinolones with Antimalarial Activity
Maignan, Jordany R, Lichorowic, Cynthia L, Giarrusso, James, Blake, Lynn D, Casandra, Debora, Mutka, Tina S, LaCrue, Alexis N, Burrows, Jeremy N, Willis, Paul A, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Journal Article
Optimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure–Activity and Structure–Property Relationships
Cross, R. Matthew, Maignan, Jordany R, Mutka, Tina S, Luong, Lisa, Sargent, Justin, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Journal Article
Orally Bioavailable 6‑Chloro-7-methoxy-4(1H)‑quinolones Efficacious against Multiple Stages of Plasmodium
Cross, R. Matthew, Flanigan, David L, Monastyrskyi, Andrii, LaCrue, Alexis N, Sáenz, Fabián E, Maignan, Jordany R, Mutka, Tina S, White, Karen L, Shackleford, David M, Bathurst, Ian, Fronczek, Frank R, Wojtas, Lukasz, Guida, Wayne C, Charman, Susan A, Burrows, Jeremy N, Kyle, Dennis E, Manetsch, Roman
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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Journal Article
ICI 56,780 Optimization: Structural-Activity and Relationship Studies of 7-(2-phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity
Maignan, Jordany R., Lichorowic, Cynthia L., Giarrusso, James V., Blake, Lynn, Casandra, Debora, Mutka, Tina S., LaCrue, Alexis N., Burrows, Jeremy N., Kyle, Dennis E., Manetsch, Roman
Published in Journal of medicinal chemistry (12.07.2016)
Published in Journal of medicinal chemistry (12.07.2016)
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Journal Article
COMPOUNDS AND METHODS FOR THEIR USE IN THE TREATMENT OF MALARIA
MANETSCH, ROMAN, BROCKMEYER, FABIAN MARCEL, MONASTYRSKYI, ANDRII, KYLE, DENNIS E, MAIGNAN, JORDANY R, LACRUE, ALEXIS N
Year of Publication 31.01.2019
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Year of Publication 31.01.2019
Patent
Quinolone-based compounds, formulations, and uses thereof
Manetsch, Roman, Kyle, Dennis E, Neelarapu, Raghupathi, Lichorowic, Cynthia L, Maignan, Jordany R, LaCrue, Alexis N
Year of Publication 19.06.2018
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Year of Publication 19.06.2018
Patent
COMPOUNDS AND METHODS FOR THEIR USE IN THE TREATMENT OF MALARIA
KYLE, Dennis, E, MAIGNAN, Jordany, R, MONASTYRSKYI, Andrii, MANETSCH, Roman, LACRUE, Alexis, N
Year of Publication 27.07.2017
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Year of Publication 27.07.2017
Patent