Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice
Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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CD98hc is a target for brain delivery of biotherapeutics
Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Published in Nature communications (19.08.2023)
Published in Nature communications (19.08.2023)
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Author Correction: CD98hc is a target for brain delivery of biotherapeutics
Chew, Kylie S., Wells, Robert C., Moshkforoush, Arash, Chan, Darren, Lechtenberg, Kendra J., Tran, Hai L., Chow, Johann, Kim, Do Jin, Robles-Colmenares, Yaneth, Srivastava, Devendra B., Tong, Raymond K., Tong, Mabel, Xa, Kaitlin, Yang, Alexander, Zhou, Yinhan, Akkapeddi, Padma, Annamalai, Lakshman, Bajc, Kaja, Blanchette, Marie, Cherf, Gerald Maxwell, Earr, Timothy K., Gill, Audrey, Huynh, David, Joy, David, Knight, Kristen N., Lac, Diana, Leung, Amy Wing-Sze, Lexa, Katrina W., Liau, Nicholas P. D., Becerra, Isabel, Malfavon, Mario, McInnes, Joseph, Nguyen, Hoang N., Lozano, Edwin I., Pizzo, Michelle E., Roche, Elysia, Sacayon, Patricia, Calvert, Meredith E. K., Daneman, Richard, Dennis, Mark S., Duque, Joseph, Gadkar, Kapil, Lewcock, Joseph W., Mahon, Cathal S., Meisner, René, Solanoy, Hilda, Thorne, Robert G., Watts, Ryan J., Zuchero, Y. Joy Yu, Kariolis, Mihalis S.
Published in Nature communications (07.09.2023)
Published in Nature communications (07.09.2023)
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu
Published in Science translational medicine (27.05.2020)
Published in Science translational medicine (27.05.2020)
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Inhibition of a Secreted Glutamic Peptidase Prevents Growth of the Fungus Talaromyces emersonii
O'Donoghue, Anthony J., Mahon, Cathal S., Goetz, David H., O'Malley, James M., Gallagher, Denise M., Zhou, Min, Murray, Patrick G., Craik, Charles S., Tuohy, Maria G.
Published in The Journal of biological chemistry (24.10.2008)
Published in The Journal of biological chemistry (24.10.2008)
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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme
Arguello, Annie, Mahon, Cathal S, Calvert, Meredith E K, Chan, Darren, Dugas, Jason C, Pizzo, Michelle E, Thomsen, Elliot R, Chau, Roni, Damo, Lorna A, Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N, Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C, Wang, Junhua, Dennis, Mark S, Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R, Lewcock, Joseph W, Sanchez, Pascal E, Troyer, Matthew D, Harris, Jeffrey M, Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J, Thorne, Robert G, Henry, Anastasia G, Kariolis, Mihalis S
Published in The Journal of experimental medicine (07.03.2022)
Published in The Journal of experimental medicine (07.03.2022)
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Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr
DePaula-Silva, Ana Beatriz, Cassiday, Patrick A, Chumley, Jeffrey, Bosque, Alberto, Monteiro-Filho, Carlos M.R, Mahon, Cathal S, Cone, Kelsey R, Krogan, Nevan, Elde, Nels C, Planelles, Vicente
Published in Virology (New York, N.Y.) (01.03.2015)
Published in Virology (New York, N.Y.) (01.03.2015)
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Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii
Mahon, Cathal S, O'Donoghue, Anthony J, Goetz, David H, Murray, Patrick G, Craik, Charles S, Tuohy, Maria G
Published in Microbiology (Society for General Microbiology) (01.11.2009)
Published in Microbiology (Society for General Microbiology) (01.11.2009)
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알파-L-이두 로니다제 효소를 포함하는 융합 단백질 및 이의 방법
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Year of Publication 06.08.2024
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GU ZHENYU, MONROE KATHRYN M, PARK JOSHUA I, PROROK RACHEL, DENNIS MARK S, MAHON CATHAL S, VAN LENGERICH BETTINA, SILVERMAN ADAM P, KARIOLIS MIHALIS S
Year of Publication 27.09.2022
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Year of Publication 27.09.2022
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SHAN LU, TRAN HAI L, BARKER SCARLETT, TONG RAYMOND KA HANG, WELLS ROBERT C, KARIOLIS MIHALIS S, DEVOS SARAH L, ESTRADA ANTHONY A, PARK JOSHUA I, DENNIS MARK S, NILEWSKI LIZANNE G, ZUCHERO JOY YU, MAHON CATHAL S, THAYER MAI B
Year of Publication 06.03.2024
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Year of Publication 06.03.2024
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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, corrects heparan sulfate accumulation, lysosomal lipid storage and inflammation in MPS IIIA mouse brain
Masoud, Shababa T., Jafarnejad, Mohammad, Nguyen, Hoang, Tsogtbaatar, Buyankhishig, Rajendra, Yashas, Seay, Alexander, Thomsen, Elliot R., Yamanokuchi, Kensuke, Arguello, Annie, Fang, Meng, Mahon, Cathal S., Sanchez, Pascal, Diaz, Dolo, Bakardjiev, Anna, Henne, Kirk
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
Guo, Jing L., Braun, Dylan, Fitzgerald, Gabriel A., Hsieh, Yun-Ting, Rougé, Lionel, Litvinchuk, Alexandra, Steffek, Micah, Propson, Nicholas E., Heffner, Catherine M., Discenza, Claire, Han, Suk Ji, Rana, Anil, Skuja, Lukas L., Lin, Bi Qi, Sun, Elizabeth W., Davis, Sonnet S., Balasundar, Srijana, Becerra, Isabel, Dugas, Jason C., Ha, Connie, Hsiao-Nakamoto, Jennifer, Huang, Fen, Jain, Shourya, Kung, Jennifer E., Liau, Nicholas P.D., Mahon, Cathal S., Nguyen, Hoang N., Nguyen, Nathan, Samaddar, Madhuja, Shi, Yajuan, Tatarakis, David, Tian, Yuxi, Zhu, Yuda, Suh, Jung H., Sandmann, Thomas, Calvert, Meredith E.K., Arguello, Annie, Kane, Lesley A., Lewcock, Joseph W., Holtzman, David M., Koth, Christopher M., Di Paolo, Gilbert
Published in Cell (01.11.2024)
Published in Cell (01.11.2024)
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ETV:SGSH, a brain-penetrant enzyme transport vehicle for SGSH, improves lysosomal and microglial morphology, degeneration and cognitive behavior in MPS IIIA mice
Masoud, Shababa T., Nguyen, Hoang, Discenza, Claire, Joy, David, Simms, Jeffrey, Lo, Iris, Chun, You Young, Holtzman, Julia, Tsogtbaatar, Khishig, Leung, Amy Wing-Sze, Becerra, Isabel, Thomsen, Elliot, Gill, Audrey, Rajendra, Yashas, Seay, Alexander, Jafarnejad, Mohammad, Bakardjiev, Anna, Calvert, Meredith E.K., Mahon, Cathal S., Thorne, Robert, Chessler, Steven, Henne, Kirk, Sanchez, Pascal, Arguello, Annie
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Published in Molecular genetics and metabolism (01.02.2024)
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Determinants for degradation of SAMHD1, Mus81 and induction of G 2 arrest in HIV-1 Vpr and SIVagm Vpr
DePaula-Silva, Ana Beatriz, Cassiday, Patrick A., Chumley, Jeffrey, Bosque, Alberto, Monteiro-Filho, Carlos M.R., Mahon, Cathal S., Cone, Kelsey R., Krogan, Nevan, Elde, Nels C., Planelles, Vicente
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Published in Virology (New York, N.Y.) (01.03.2015)
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FUSION PROTEINS COMPRISING SULFOGLUCOSAMINE SULFOHYDROLASE ENZYMES AND METHODS THEREOF
KARIOLIS, Mihalis S, KANNAN, Gunasekaran, MAHON, Cathal S, GIESE, Tina
Year of Publication 09.05.2024
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Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
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Year of Publication 30.01.2024
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FUSION PROTEINS COMPRISING ALPHA-L-IDURONIDASE ENZYMES AND METHODS
KARIOLIS, Mihalis S, ADUSUMILLI, Gowrisudha, MAHON, Cathal S, DAVIS, Oliver Brayer, YAMANOKUCHI, Kensuke, TYAGI, Shrishti
Year of Publication 23.10.2024
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FUSION PROTEINS COMPRISING ALPHA-L-IDURONIDASE ENZYMES AND METHODS
KARIOLIS, Mihalis S, ADUSUMILLI, Gowrisudha, MAHON, Cathal S, DAVIS, Oliver Brayer, YAMANOKUCHI, Kensuke, TYAGI, Shrishti
Year of Publication 04.07.2024
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ANTI-TRANSFERRIN RECEPTOR FUSION PROTEINS AND METHODS OF USE THEREOF
KARIOLIS, Mihalis S, KANNAN, Gunasekaran, MAHON, Cathal S, WANG, Junhua, ARGUELLO, Annie, GIESE, Tina
Year of Publication 09.05.2024
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