Discovery of PiragliatinFirst Glucokinase Activator Studied in Type 2 Diabetic Patients
Sarabu, Ramakanth, Bizzarro, Fred T, Corbett, Wendy L, Dvorozniak, Mark T, Geng, Wanping, Grippo, Joseph F, Haynes, Nancy-Ellen, Hutchings, Stanley, Garofalo, Lisa, Guertin, Kevin R, Hilliard, Darryl W, Kabat, Marek, Kester, Robert F, Ka, Wang, Liang, Zhenmin, Mahaney, Paige E, Marcus, Linda, Matschinsky, Franz M, Moore, David, Racha, Jagdish, Radinov, Roumen, Ren, Yi, Qi, Lida, Pignatello, Michael, Spence, Cheryl L, Steele, Thomas, Tengi, John, Grimsby, Joseph
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Journal Article
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
Grimsby, Joseph, Sarabu, Ramakanth, Corbett, Wendy L., Haynes, Nancy-Ellen, Bizzarro, Fred T., Coffey, John W., Guertin, Kevin R., Hilliard, Darryl W., Kester, Robert F., Mahaney, Paige E., Marcus, Linda, Qi, Lida, Spence, Cheryl L., Tengi, John, Magnuson, Mark A., Chu, Chang An, Dvorozniak, Mark T., Matschinsky, Franz M., Grippo, Joseph F.
Published in Science (American Association for the Advancement of Science) (18.07.2003)
Published in Science (American Association for the Advancement of Science) (18.07.2003)
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Journal Article
A synthetic farnesoid X receptor (FXR) agonist promotes cholesterol lowering in models of dyslipidemia
Evans, Mark J, Mahaney, Paige E, Borges-Marcucci, Lisa, Lai, KehDih, Wang, Shuguang, Krueger, Julie A, Gardell, Stephen J, Huard, Christine, Martinez, Robert, Vlasuk, George P, Harnish, Douglas C
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2009)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2009)
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Journal Article
Desvenlafaxine Succinate Identifies Novel Antagonist Binding Determinants in the Human Norepinephrine Transporter
Mason, John N, Deecher, Darlene C, Richmond, Rhonda L, Stack, Gary, Mahaney, Paige E, Trybulski, Eugene, Winneker, Richard C, Blakely, Randy D
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Journal Article
Synthesis and activity of a new class of pathway-selective estrogen receptor ligands: Hydroxybenzoyl-3,4-dihydroquinoxalin-2(1 H)-ones
Mahaney, Paige E., Webb, Michael B., Ye, Fei, Sabatucci, Joseph P., Steffan, Robert J., Chadwick, Christopher C., Harnish, Douglas C., Trybulski, Eugene J.
Published in Bioorganic & medicinal chemistry (15.05.2006)
Published in Bioorganic & medicinal chemistry (15.05.2006)
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Journal Article
Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)
Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Development of an Asymmetric Synthesis of a Chiral Quaternary FLAP Inhibitor
Fandrick, Keith R, Mulder, Jason A, Patel, Nitinchandra D, Gao, Joe, Konrad, Michael, Archer, Elizabeth, Buono, Frederic G, Duran, Adil, Schmid, Rolf, Daeubler, Juergen, Desrosiers, Jean-Nicolas, Zeng, Xingzhong, Rodriguez, Sonia, Ma, Shengli, Qu, Bo, Li, Zhibin, Fandrick, Daniel R, Grinberg, Nelu, Lee, Heewon, Bosanac, Todd, Takahashi, Hidenori, Chen, Zhidong, Bartolozzi, Alessandra, Nemoto, Peter, Busacca, Carl A, Song, Jinhua J, Yee, Nathan K, Mahaney, Paige E, Senanayake, Chris H
Published in Journal of organic chemistry (06.02.2015)
Published in Journal of organic chemistry (06.02.2015)
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Journal Article
Development of an Enantioselective Hydrogenation Route to (S)‑1-(2-(Methylsulfonyl)pyridin-4-yl)propan-1-amine
Reeves, Jonathan T, Tan, Zhulin, Reeves, Diana C, Song, Jinhua J, Han, Zhengxu S, Xu, Yibo, Tang, Wenjun, Yang, Bing-Shiou, Razavi, Hossein, Harcken, Christian, Kuzmich, Daniel, Mahaney, Paige E, Lee, Heewon, Busacca, Carl A, Senanayake, Chris H
Published in Organic process research & development (18.07.2014)
Published in Organic process research & development (18.07.2014)
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Journal Article
Regioselective Synthesis of Substituted Pyrroles: Efficient Palladium-Catalyzed Cyclization of Internal Alkynes and 2-Amino-3-iodoacrylate Derivatives
Crawley, Matthew L, Goljer, Igor, Jenkins, Douglas J, Mehlmann, John F, Nogle, Lisa, Dooley, Rebecca, Mahaney, Paige E
Published in Organic letters (07.12.2006)
Published in Organic letters (07.12.2006)
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Journal Article
Early Development Scale-Up of a Structurally-Challenging 5‑Lipoxygenase Activating Protein (FLAP) Inhibitor
Mulder, Jason A, Gao, Joe, Fandrick, Keith R, Zeng, Xingzhong, Desrosiers, Jean-Nicolas, Patel, Nitinchandra D, Li, Zhibin, Rodriguez, Sonia, Lorenz, Jon C, Wang, Jun, Ma, Shengli, Fandrick, Daniel R, Grinberg, Nelu, Lee, Heewon, Bosanac, Todd, Takahashi, Hidenori, Chen, Zhidong, Bartolozzi, Alessandra, Nemoto, Peter, Busacca, Carl A, Song, Jinhua J, Yee, Nathan K, Mahaney, Paige E, Senanayake, Chris H
Published in Organic process research & development (15.09.2017)
Published in Organic process research & development (15.09.2017)
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Discovery, Structure−Activity Relationships, Pharmacokinetics, and Efficacy of Glucokinase Activator (2R)-3-Cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675)
Haynes, Nancy-Ellen, Corbett, Wendy L, Bizzarro, Fred T, Guertin, Kevin R, Hilliard, Darryl W, Holland, George W, Kester, Robert F, Mahaney, Paige E, Qi, Lida, Spence, Cheryl L, Tengi, John, Dvorozniak, Mark T, Railkar, Aruna, Matschinsky, Franz M, Grippo, Joseph F, Grimsby, Joseph, Sarabu, Ramakanth
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
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Journal Article
Improvement of Physiochemical Properties of the Tetrahydroazepinoindole Series of Farnesoid X Receptor (FXR) Agonists: Beneficial Modulation of Lipids in Primates
Lundquist, Joseph T, Harnish, Douglas C, Kim, Callain Y, Mehlmann, John F, Unwalla, Rayomand J, Phipps, Kristin M, Crawley, Matthew L, Commons, Thomas, Green, Daniel M, Xu, Weixin, Hum, Wah-Tung, Eta, Julius E, Feingold, Irene, Patel, Vikram, Evans, Mark J, Lai, KehDih, Borges-Marcucci, Lisa, Mahaney, Paige E, Wrobel, Jay E
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Journal Article
Efficient, Regioselective Palladium-Catalyzed Tandem Heck-Isomerization Reaction of Aryl Bromides and Non-Allylic Benzyl Alcohols
Crawley, Matthew L, Phipps, Kristin M, Goljer, Igor, Mehlmann, John F, Lundquist, Joseph T, Ullrich, John W, Yang, Cuijian, Mahaney, Paige E
Published in Organic letters (05.03.2009)
Published in Organic letters (05.03.2009)
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Journal Article
1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as Potent and Selective Norepinephrine Reuptake Inhibitors
Vu, An T, Cohn, Stephen T, Zhang, Puwen, Kim, Callain Y, Mahaney, Paige E, Bray, Jenifer A, Johnston, Grace H, Koury, Elizabeth J, Cosmi, Scott A, Deecher, Darlene C, Smith, Valerie A, Harrison, James E, Leventhal, Liza, Whiteside, Garth T, Kennedy, Jeffrey D, Trybulski, Eugene J
Published in Journal of medicinal chemistry (11.03.2010)
Published in Journal of medicinal chemistry (11.03.2010)
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Journal Article
Discovery of a new series of monoamine reuptake inhibitors, the 1-amino-3-(1 H-indol-1-yl)-3-phenylpropan-2-ols
Kim, Callain Y., Mahaney, Paige E., McConnell, Oliver, Zhang, Yingru, Manas, Eric, Ho, Douglas M., Deecher, Darlene C., Trybulski, Eugene J.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Synthesis and activity of novel 1-or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors
PUWEN ZHANG, TEREFENKO, Eugene A, MCCOMAS, Casey C, MAHANEY, Paige E, AN VU, TRYBULSKI, Eugene, KOURY, Elizabeth, JOHNSTON, Grace, BRAY, Jenifer, DEECHER, Darlene
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles
HEFFERNAN, GavinD, COGHLAN, Richard D, COSMI, Scott A, JOHNSTON, Grace H, KENNEY, Thomas, KOURY, Elizabeth, WINNEKER, Richard C, DEECHER, Darlene C, TRYBULSKI, Eugene J, MANAS, Eric S, MCDEVITT, Robert E, YANFANG LI, MAHANEY, Paige E, ROBICHAUD, Albert J, HUSELTON, Christine, ALFINITO, Peter, BRAY, Jenifer A
Published in Bioorganic & medicinal chemistry (15.11.2009)
Published in Bioorganic & medicinal chemistry (15.11.2009)
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Journal Article
Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors
Sabatucci, Joseph P., Mahaney, Paige E., Leiter, Jennifer, Johnston, Grace, Burroughs, Kevin, Cosmi, Scott, Zhang, Yingru, Ho, Douglas, Deecher, Darlene C., Trybulski, Eugene
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1 H-indol-1-yl)-3-arylpropan-1-amines
Mahaney, Paige E., Vu, An T., McComas, Casey C., Zhang, Puwen, Nogle, Lisa M., Watts, William L., Sarkahian, Ani, Leventhal, Liza, Sullivan, Nicole R., Uveges, Albert J., Trybulski, Eugene J.
Published in Bioorganic & medicinal chemistry (15.12.2006)
Published in Bioorganic & medicinal chemistry (15.12.2006)
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Journal Article
Structure−Activity Relationships of the Cycloalkanol Ethylamine Scaffold: Discovery of Selective Norepinephrine Reuptake Inhibitors
Mahaney, Paige E, Gavrin, Lori K, Trybulski, Eugene J, Stack, Gary P, Vu, An T, Cohn, Stephen T, Ye, Fei, Belardi, Justin K, Santilli, Arthur A, Sabatucci, Joseph P, Leiter, Jennifer, Johnston, Grace H, Bray, Jenifer A, Burroughs, Kevin D, Cosmi, Scott A, Leventhal, Liza, Koury, Elizabeth J, Zhang, Yingru, Mugford, Cheryl A, Ho, Douglas M, Rosenzweig-Lipson, Sharon J, Platt, Brian, Smith, Valerie A, Deecher, Darlene C
Published in Journal of medicinal chemistry (10.07.2008)
Published in Journal of medicinal chemistry (10.07.2008)
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