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Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
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Published in Journal of medicinal chemistry (24.09.2015)
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Inhibition of MAP Kinase Kinase Causes Morphological Reversion and Dissociation between Soft Agar Growth and in Vivo Tumorigenesis in Angiosarcoma Cells
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Published in The American journal of pathology (01.12.2000)
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VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease
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Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3‑Kinase γ
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Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3‑Kinase γ
Collier, Philip N., Messersmith, David, Le Tiran, Arnaud, Bandarage, Upul K., Boucher, Christina, Come, Jon, Cottrell, Kevin M., Damagnez, Veronique, Doran, John D., Griffith, James P., Khare-Pandit, Suvarna, Krueger, Elaine B., Ledeboer, Mark W., Ledford, Brian, Liao, Yusheng, Mahajan, Sudipta, Moody, Cameron S., Roday, Setu, Wang, Tiansheng, Xu, Jinwang, Aronov, Alex M.
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3K gamma Inhibitors
Bandarage, Upul K., Aronov, Alex M., Cao, Jingrong, Come, Jon H., Cottrell, Kevin M., Davies, Robert J., Giroux, Simon, Jacobs, Marc, Mahajan, Sudipta, Messersmith, David, Moody, Cameron S., Swett, Rebecca, Xu, Jinwang
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
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The Generation and Characterization of a Cell Line Derived from a Sporadic Renal Angiomyolipoma
Arbiser, Jack L., Yeung, Raymond, Weiss, Sharon W., Arbiser, Zoya K., Amin, Mahul B., Cohen, Cynthia, Frank, David, Mahajan, Sudipta, Herron, G. Scott, Yang, Jiwei, Onda, Hiroki, Zhang, H.B., Bai, Xianhe, Uhlmann, Erik, Loehr, Allison, Northrup, Hope, Au, Paul, Davis, Ian, Fisher, David E., Gutmann, David H.
Published in The American journal of pathology (01.08.2001)
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CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable
Lin, Michelle I., Paik, Elizabeth, Mishra, Bibhu, Burkhardt, David, Kernytsky, Andrew, Pettiglio, Michael, Chen, Yi-Shan, Tomkinson, Kaleigh, Woo, Amanda, Cortes, Mauricio, Tan, Siyuan, Borland, Todd D, Klein, Lawrence, Yen, Angela, Mahajan, Sudipta, Chan, Eric, Eustace, Brenda, Porteus, Matthew, Chakraborty, Tirtha, Cowan, Chad, Novak, Rodger, Lundberg, Ante
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Published in Blood (08.12.2017)
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Abstract LB-B15: A novel PI3K gamma isoform selective small molecule kinase inhibitor demonstrates single agent anti-tumor activity and enhanced combination activity with checkpoint blockade in syngeneic mouse models of cancer
Saha, Saurabh, Zhang, Linping, Hoock, Thomas, Aronov, Alex, Mahajan, Sudipta, Boyd, Michael, Come, Jon, Damagnez, Veronique, Dworakowski, Wojciech, Khare-Pandit, Suvarna, LeTiran, Arnaud, Moody, Cameron, O'Dowd, Harwin, Prezioso, Joseph, Roday, Setu, Zhang, Xiaoyan M.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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유전체 편집 효율을 증가시키기 위한 퀴녹살리논 화합물, 조성물, 방법 및 키트
WEINBERG MARC SAUL, D'ASTOLFO DIEGO SEBASTIAN, MORRIS MARK A, COTTRELL KEVIN M, MAXWELL JOHN PATRICK, MAHAJAN SUDIPTA
Year of Publication 24.09.2020
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Year of Publication 24.09.2020
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Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole
Wang, Tiansheng, Duffy, John P, Wang, Jian, Halas, Summer, Salituro, Francesco G, Pierce, Albert C, Zuccola, Harmon J, Black, James R, Hogan, James K, Jepson, Scott, Shlyakter, Dina, Mahajan, Sudipta, Gu, Yong, Hoock, Thomas, Wood, Mark, Furey, Brinley F, Frantz, J. Daniel, Dauffenbach, Lisa M, Germann, Ursula A, Fan, Bin, Namchuk, Mark, Bennani, Youssef L, Ledeboer, Mark W
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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2-Aminopyrazolo[1,5- a]pyrimidines as potent and selective inhibitors of JAK2
Ledeboer, Mark W., Pierce, Albert C., Duffy, John P., Gao, Huai, Messersmith, David, Salituro, Francesco G., Nanthakumar, Suganthini, Come, Jon, Zuccola, Harmon J., Swenson, Lora, Shlyakter, Dina, Mahajan, Sudipta, Hoock, Thomas, Fan, Bin, Tsai, Wan-Jung, Kolaczkowski, Elaine, Carrier, Scott, Hogan, James K., Zessis, Richard, Pazhanisamy, S., Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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