Preclinical Characterization of PWT143, a Novel Selective and Potent Phosphatidylinositol 3-kinase Delta (PI3K delta) Inhibitor with Ex-Vivo Activity in Hematologic Malignancies
O'Farrell, Marie, Ventura, Richard, Tai, Albert, Tyner, Jeffrey W, Loriaux, Marc M, Mahadevan, Daruka, Morales, Carla, Brown, S. David, Matthews, David J
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Assessment of Regional Variability in COVID-19 Outcomes Among Patients With Cancer in the United States
Hawley, Jessica E, Sun, Tianyi, Chism, David D, Duma, Narjust, Fu, Julie C, Gatson, Na Tosha N, Mishra, Sanjay, Nguyen, Ryan H, Reid, Sonya A, Serrano, Oscar K, Singh, Sunny R K, Venepalli, Neeta K, Bakouny, Ziad, Bashir, Babar, Bilen, Mehmet A, Caimi, Paolo F, Choueiri, Toni K, Dawsey, Scott J, Fecher, Leslie A, Flora, Daniel B, Friese, Christopher R, Glover, Michael J, Gonzalez, Cyndi J, Goyal, Sharad, Halfdanarson, Thorvardur R, Hershman, Dawn L, Khan, Hina, Labaki, Chris, Lewis, Mark A, McKay, Rana R, Messing, Ian, Pennell, Nathan A, Puc, Matthew, Ravindranathan, Deepak, Rhodes, Terence D, Rivera, Andrea V, Roller, John, Schwartz, Gary K, Shah, Sumit A, Shaya, Justin A, Streckfuss, Mitrianna, Thompson, Michael A, Wulff-Burchfield, Elizabeth M, Xie, Zhuoer, Yu, Peter Paul, Warner, Jeremy L, Shah, Dimpy P, French, Benjamin, Hwang, Clara
Published in JAMA network open (04.01.2022)
Published in JAMA network open (04.01.2022)
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Variations in Unrealistic Optimism Between Acceptors and Decliners of Early Phase Cancer Trials
Jansen, Lynn A., Mahadevan, Daruka, Appelbaum, Paul S., Klein, William M. P., Weinstein, Neil D., Mori, Motomi, Degnin, Catherine, Sulmasy, Daniel P.
Published in Journal of empirical research on human research ethics (01.10.2017)
Published in Journal of empirical research on human research ethics (01.10.2017)
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Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach
Warner, Steven L, Bashyam, Sridevi, Vankayalapati, Hariprasad, Bearss, David J, Han, Haiyong, Mahadevan, Daruka, Von Hoff, Daniel D, Hurley, Laurence H
Published in Molecular cancer therapeutics (01.07.2006)
Published in Molecular cancer therapeutics (01.07.2006)
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First-in-human phase I study: Results of a second-generation non-ansamycin heat shock protein 90 (HSP90) inhibitor AT13387 in refractory solid tumors
Mahadevan, Daruka, Rensvold, Diane M, Kurtin, Sandra E, Cleary, James M., Gandhi, Leena, Lyons, John F., Lock, Victoria, Lewis, Samantha, Shapiro, Geoffrey
Published in Journal of clinical oncology (20.05.2012)
Published in Journal of clinical oncology (20.05.2012)
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Phase Ib study of safety, tolerability, and efficacy of R1507 a monoclonal antibody to IGF-1R in combination with multiple standard chemotherapy regimens in patients with advanced solid malignancies
Mahadevan, Daruka, Sutton, Gregory Ryan, Arteta-Bulos, Rafael, Bowden, Chris J., Miller, Paul J. E., Swart, Rachel Elizabeth, Walker, Mark S., Munster, Pamela N., Dees, Elizabeth Claire, Marshall, John, Hamid, Omid, Kurzrock, Razelle
Published in Journal of clinical oncology (20.05.2013)
Published in Journal of clinical oncology (20.05.2013)
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A phase I trial of ublituximab (TG-1101), a novel glycoengineered anti-CD20 monoclonal antibody (mAb) in B-cell non-Hodgkin lymphoma patients with prior exposure to rituximab
O'Connor, Owen A., Deng, Changchun, Amengual, Jennifer Effie, Khalil, Mazen Y., Schreeder, Marshall T., Mahadevan, Daruka, Nikolinakos, Petros, Sawas, Ahmed, Zain, Jasmine M., Patterson, Molly, Moon, Amber, Pauli, Emily K., Cutter, Kathy, Mackenzie, Michelle Ann, Brotherton, Marnie, Hodgson, Jamie, Cooper, Christen N, Sportelli, Peter, Miskin, Hari P., Farber, Charles Michael
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Abstract 1745: Translational medicine enables rapid early clinical development of AVL-292, a highly selective, orally available inhibitor of Bruton's tyrosine kinase, in a phase 1b clinical trial
Westlin, William F., Stiede, Kathryn, Lounsbury, Heather, Witowski, Steve, Silver, Bruce, Freed, Martin, Mahadevan, Daruka, Sharman, Jeff, Harb, Wael A., Petter, Russell, Singh, Juswinder, Evans, Erica
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract 1643: Withaferin A analogues up-regulate the MAPK and glutathione metabolic pathways prior to activation of apoptosis in pancreatic cancer cells
Mahadevan, Daruka, Liu, Xiaobing, Qi, Wenqing, Cooke, Laurence, Wijevatne, Kithsiri, Marron, Marilyn, Gunatilaka, Leslie
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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Phase 2 Trial of Alisertib (MLN8237), An Investigational, Potent Inhibitor of Aurora A Kinase (AAK), in Patients (pts) with Aggressive B- and T-Cell Non-Hodgkin Lymphoma (NHL)
Friedberg, Jonathan, Mahadevan, Daruka, Jung, JungAh, Persky, Daniel O., Lossos, Izidore S, Danaee, Hadi, Zhou, Xiaofei, Leonard, E Jane, Bernstein, Steven H.
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Mitotic Spindle Assembly Inhibition Through Aurora A (MLN8237) Plus Vincristine Is Synthetic Lethal and Synergizes with Rituximab As a Curative Therapy in Aggressive B-Cell Non-Hodgkin Lymphoma
Mahadevan, Daruka, Cooke, Laurence, Stejskal, Amy, Manziello, Ann, Morales, Carla, Persky, Daniel O., Fisher, Richard I, Miller, Thomas P., Qi, Wenqing
Published in Blood (18.11.2011)
Published in Blood (18.11.2011)
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Addition of Rituximab to MLN8237 An Aurora A Kinase Inhibitor Plus Vincristine or Docetaxel Has Synergistic Anti-Tumor Activity In a Mouse Model of Aggressive B-Cell Non-Hodgkin's Lymphoma
Mahadevan, Daruka, Cooke, Laurence, Liu, Xiaobing, Persky, Daniel Oscar, Spier, Catherine M., Miller, Thomas P., Qi, Wenqing
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Phase I Study of Novel Prodrug Dual PI3K/mTOR Inhibitor SF1126 In B-Cell Malignancies
Garlich, Joseph R, Becker, Michael D, Shelton, Candace F, Qi, Wenqing, Liu, Xiaobing, Cooke, Laurence, Mahadevan, Daruka
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Phase 1 Study Of Single Agent CC-292, a Highly Selective Bruton's Tyrosine Kinase (BTK) Inhibitor, In Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)
Brown, Jennifer R., Harb, Wael A., Hill, Brian T., Gabrilove, Janice, Sharman, Jeff P., Schreeder, Marshall T., Barr, Paul M., Foran, James M., Miller, Thomas P., Burger, Jan A., Kelly, Kevin R., Mahadevan, Daruka, Ma, Shuo, Barnett, Evelyn, Marine, Jeffrey, Nava-Parada, Pilar, Azaryan, Ada, Mei, Jay, Kipps, Thomas J.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Phase 1 Study Of Investigational Agent MLN8237 (Alisertib) + Rituximab ± Vincristine In Patients (Pts) With Relapsed/Refractory (Rel/Ref) Aggressive B-Cell Lymphomas
Kelly, Kevin R., Persky, Daniel O., Mahadevan, Daruka, Miller, Thomas P., Puvvada, Soham D., McDonagh, Kevin, Hayslip, John, Park, Steven I., Ruan, Jia, Rosen, Peter J., Iyer, Swaminathan Padmanabhan, Stefanovic, Alexandra, Zhang, Bin, Zhou, Xiaofei, Ullmann, Claudio Dansky, Leonard, E. Jane, Friedberg, Jonathan W.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer
RAUNCH, Matthew P, HAHN, Tobias, LEE, Wen-Cherng, LING, Leona E, AKPORIAYE, Emmanuel T, RAMANATHAPURAM, Lalitha, BRADLEY-DUNLOP, Deborah, MAHADEVAN, Daruka, MERCADO-PIMENTEL, Melania E, RUNYAN, Raymond B, BESSELSEN, David G, XIAMEI ZHANG, CHEUNG, H.-Kam
Published in Anticancer research (01.06.2009)
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Published in Anticancer research (01.06.2009)
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First-In-Human Phase I Dose Escalation Study of a Humanized Anti-CD200 Antibody (Samalizumab) In Patients with Advanced Stage B Cell Chronic Lymphocytic Leukemia (B-CLL) or Multiple Myeloma (MM)
Mahadevan, Daruka, Lanasa, Mark C, Whelden, Maria, Faas, Susan J, Ulery, Terrie L, Kukreja, Anjli, Li, Lan, Bedrosian, Camille L, Heffner, Leonard T
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Targeting Aurora Kinase in Aggressive B-Cell Non-Hodgkin's Lymphomas
Mahadevan, Daruka, Qi, Wenqing, Cooke, Laurence, Lui, Xiabing, Persky, Daniel Oscar, Rimsza, Lisa M., Miller, Thomas P.
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Aurora Inhibitor MLN8237 in Combination with Docetaxel Enhances Apoptosis and Antitumor Activity in Mantle Cell Lymphoma
Qi, Wenqing, Cooke, Laurence S., Liu, Xiaobing, Rimsza, Lisa, Roe, Denise J., Manziolli, Ann, Persky, Daniel O., Miller, Thomas P., Mahadevan, Daruka
Published in Biochemical pharmacology (01.02.2011)
Published in Biochemical pharmacology (01.02.2011)
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