Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors
Fischmann, Thierry O, Smith, Catherine K, Mayhood, Todd W, Myers, Joseph E, Reichert, Paul, Mannarino, Anthony, Carr, Donna, Zhu, Hugh, Wong, Jesse, Yang, Rong-Sheng, Le, Hung V, Madison, Vincent S
Published in Biochemistry (Easton) (31.03.2009)
Published in Biochemistry (Easton) (31.03.2009)
Get full text
Journal Article
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
Get full text
Journal Article
Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor
Deng, Yongqi, Shipps, Gerald W., Zhao, Lianyun, Siddiqui, M. Arshad, Popovici-Muller, Janeta, Curran, Patrick J., Duca, Jose S., Hruza, Alan W., Fischmann, Thierry O., Madison, Vincent S., Zhang, Rumin, McNemar, Charles W., Mayhood, Todd W., Syto, Rosalinda, Annis, Allen, Kirschmeier, Paul, Lees, Emma M., Parry, David A., Windsor, William T.
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Published in Bioorganic & medicinal chemistry letters (01.01.2014)
Get full text
Journal Article
Solution Structure of the Ras-Binding Domain of c-Raf-1 and Identification of Its Ras Interaction Surface
Emerson, S. Donald, Madison, Vincent S, Palermo, Robert E, Waugh, David S, Scheffler, Julie E, Tsao, Kwei-Lan, Kiefer, Susan E, Liu, Shuang P, Fry, David C
Published in Biochemistry (Easton) (30.05.1995)
Published in Biochemistry (Easton) (30.05.1995)
Get full text
Journal Article
Cross-Docking of Inhibitors into CDK2 Structures. 1
Duca, José S, Madison, Vincent S, Voigt, Johannes H
Published in Journal of chemical information and modeling (01.03.2008)
Published in Journal of chemical information and modeling (01.03.2008)
Get full text
Journal Article
Cross-Docking of Inhibitors into CDK2 Structures. 2
Voigt, Johannes H, Elkin, Carl, Madison, Vincent S, Duca, José S
Published in Journal of chemical information and modeling (01.03.2008)
Published in Journal of chemical information and modeling (01.03.2008)
Get full text
Journal Article
Design and Synthesis of Depeptidized Macrocyclic Inhibitors of Hepatitis C NS3-4A Protease Using Structure-Based Drug Design
Venkatraman, Srikanth, Njoroge, F. George, Girijavallabhan, Viyyoor M, Madison, Vincent S, Yao, Nanua H, Prongay, Andrew J, Butkiewicz, Nancy, Pichardo, John
Published in Journal of medicinal chemistry (11.08.2005)
Published in Journal of medicinal chemistry (11.08.2005)
Get full text
Journal Article
Structure of interleukin 1 .alpha. at 2.7-.ANG. resolution
Graves, Bradford J, Hatada, Marcos H, Hendrickson, Wayne A, Miller, Julann K, Madison, Vincent S, Satow, Yoshinori
Published in Biochemistry (Easton) (20.03.1990)
Published in Biochemistry (Easton) (20.03.1990)
Get full text
Journal Article
Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties
Olson, Gary L, Cheung, Ho-Chuen, Chiang, Elliot, Madison, Vincent S, Sepinwall, Jerry, Vincent, George P, Winokur, Andrew, Gary, Keith A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
Get full text
Journal Article
Solution structure of an analog of vasoactive intestinal peptide as determined by two-dimensional NMR and circular dichroism spectroscopies and constrained molecular dynamics
Fry, David C, Madison, Vincent S, Bolin, David R, Greeley, David N, Toome, Voldemar, Wegrzynski, Bogda B
Published in Biochemistry (Easton) (21.03.1989)
Published in Biochemistry (Easton) (21.03.1989)
Get full text
Journal Article
N-(Carboxymethyl)-N-[3,5-bis(decyloxy)phenyl]glycine (Ro 23-9358): a potent inhibitor of secretory phospholipases A2 with antiinflammatory activity
LeMahieu, Ronald A, Carson, Mathew, Han, Ru Jen, Madison, Vincent S, Hope, William C, Chen, Ting, Morgan, Douglas W, Hendrickson, H. Stewart
Published in Journal of medicinal chemistry (01.10.1993)
Published in Journal of medicinal chemistry (01.10.1993)
Get full text
Journal Article
Synthesis, biological activity and conformational analysis of cyclic GRF analogs
Felix, A M, Heimer, E P, Wang, C T, Lambros, T J, Fournier, A, Mowles, T F, Maines, S, Campbell, R M, Wegrzynski, B B, Toome, V
Published in International journal of peptide and protein research (01.12.1988)
Published in International journal of peptide and protein research (01.12.1988)
Get more information
Journal Article
Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel [mu]M Leads for the Development of nM BACE-1 ([beta]-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H., Kennedy, Matthew E., Beyer, Brian M., Senior, Mary M., Smith, Elizabeth M., Nechuta, Terry L., Madison, Vincent S., Czarniecki, Michael, McKittrick, Brian A., Stamford, Andrew W., Parker, Eric M., Hunter, John C., Greenlee, William J., Wyss, Daniel F.
Published in Journal of medicinal chemistry (18.10.2010)
Published in Journal of medicinal chemistry (18.10.2010)
Get full text
Journal Article