Characterization of LY3023414, a Novel PI3K/mTOR Dual Inhibitor Eliciting Transient Target Modulation to Impede Tumor Growth
Smith, Michele C, Mader, Mary M, Cook, James A, Iversen, Philip, Ajamie, Rose, Perkins, Everett, Bloem, Laura, Yip, Yvonne Y, Barda, David A, Waid, Philip P, Zeckner, Douglas J, Young, Debra A, Sanchez-Felix, Manuel, Donoho, Gregory P, Wacheck, Volker
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes
Hartung, Ingo V., Rudolph, Joachim, Mader, Mary M., Mulder, Monique P. C., Workman, Paul
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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Journal Article
Which Small Molecule? Selecting Chemical Probes for Use in Cancer Research and Target Validation
Mader, Mary M, Rudolph, Joachim, Hartung, Ingo V, Uehling, David, Workman, Paul, Zuercher, William
Published in Cancer discovery (05.10.2023)
Published in Cancer discovery (05.10.2023)
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Journal Article
The promise and peril of chemical probes
Arrowsmith, Cheryl H, Audia, James E, Austin, Christopher, Baell, Jonathan, Bennett, Jonathan, Blagg, Julian, Bountra, Chas, Brennan, Paul E, Brown, Peter J, Bunnage, Mark E, Buser-Doepner, Carolyn, Campbell, Robert M, Carter, Adrian J, Cohen, Philip, Copeland, Robert A, Cravatt, Ben, Dahlin, Jayme L, Dhanak, Dashyant, Edwards, Aled M, Frederiksen, Mathias, Frye, Stephen V, Gray, Nathanael, Grimshaw, Charles E, Hepworth, David, Howe, Trevor, Huber, Kilian V M, Jin, Jian, Knapp, Stefan, Kotz, Joanne D, Kruger, Ryan G, Lowe, Derek, Mader, Mary M, Marsden, Brian, Mueller-Fahrnow, Anke, Müller, Susanne, O'Hagan, Ronan C, Overington, John P, Owen, Dafydd R, Rosenberg, Saul H, Ross, Ruth, Roth, Bryan, Schapira, Matthieu, Schreiber, Stuart L, Shoichet, Brian, Sundström, Michael, Superti-Furga, Giulio, Taunton, Jack, Toledo-Sherman, Leticia, Walpole, Chris, Walters, Michael A, Willson, Timothy M, Workman, Paul, Young, Robert N, Zuercher, William J
Published in Nature chemical biology (01.08.2015)
Published in Nature chemical biology (01.08.2015)
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Journal Article
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity
Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Complete Inhibition of Anisomycin and UV Radiation but Not Cytokine Induced JNK and p38 Activation by an Aryl-substituted Dihydropyrrolopyrazole Quinoline and Mixed Lineage Kinase 7 Small Interfering RNA
Wang, Xushan, Mader, Mary M., Toth, John E., Yu, Xiaohong, Jin, Najia, Campbell, Robert M., Smallwood, Jeffrey K., Christe, Michael E., Chatterjee, Arindam, Goodson, Theodore, Vlahos, Chris J., Matter, William F., Bloem, Laura J.
Published in The Journal of biological chemistry (13.05.2005)
Published in The Journal of biological chemistry (13.05.2005)
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Journal Article
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2
Schönherr, Heike, Ayaz, Pelin, Taylor, Alexander M, Casaletto, Jessica B, Touré, B Barry, Moustakas, Demetri T, Hudson, Brandi M, Valverde, Roberto, Zhao, Songping, O'Hearn, Patrick J, Foster, Lindsey, Sharon, Dina A, Garfinkle, Sam, Giordanetto, Fabrizio, Lescarbeau, André, Kurukulasuriya, Ravi, Gerami-Moayed, Nastaran, Maglic, Dejan, Bruderek, Kamil, Naik, Gaauri, Gunaydin, Hakan, Mader, Mary M, Boezio, Alessandro A, McLean, Thomas H, Chen, Rongfeng, Wang, Yanxia, Shaw, David E, Watters, James, Bergstrom, Donald A
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (06.02.2024)
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Journal Article
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6
Shen, Yudao, Li, Fengling, Szewczyk, Magdalena M, Halabelian, Levon, Chau, Irene, Eram, Mohammad S, Dela Seña, Carlo, Park, Kwang-Su, Meng, Fanye, Chen, He, Zeng, Hong, McLeod, David, Zepeda-Velázquez, Carlos A, Campbell, Robert M, Mader, Mary M, Watson, Brian M, Schapira, Matthieu, Arrowsmith, Cheryl H, Al-Awar, Rima, Barsyte-Lovejoy, Dalia, Kaniskan, H. Ümit, Brown, Peter J, Vedadi, Masoud, Jin, Jian
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens
Gao, Cen, Margolis, Brandon J, Strelow, John M, Vidler, Lewis R, Mader, Mary M
Published in ACS medicinal chemistry letters (11.02.2016)
Published in ACS medicinal chemistry letters (11.02.2016)
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Journal Article
Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure−Activity Relationships for a Novel Class of Antitumor Agents
Lobb, Karen L, Hipskind, Philip A, Aikins, James A, Alvarez, Enrique, Cheung, Yiu-Yin, Considine, Eileen L, De Dios, Alfonso, Durst, Gregory L, Ferritto, Rafael, Grossman, Cora Sue, Giera, Deborah D, Hollister, Beth A, Huang, Zhongping, Iversen, Philip W, Law, Kevin L, Li, Tiechao, Lin, Ho-Shen, Lopez, Beatriz, Lopez, Jose E, Cabrejas, Luisa M. Martin, McCann, Denis J, Molero, Victoriano, Reilly, John E, Richett, Michael E, Shih, Chuan, Teicher, Beverly, Wikel, James H, White, Wesley T, Mader, Mary M
Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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Journal Article
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Mader, Mary M., Shih, Chuan, Considine, Eileen, Dios, Alfonso De, Grossman, Cora Sue, Hipskind, Philip A., Lin, Ho-Shen, Lobb, Karen L., Lopez, Beatriz, Lopez, José E., Cabrejas, Luisa M. Martin, Richett, Michael E., White, Wesley T., Cheung, Yiu-Yin, Huang, Zhongping, Reilly, John E., Dinn, Sean R.
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article
FGFR 저해제 및 이의 사용 방법
GIORDANETTO FABRIZIO, TOURE BAKARY BARRY, SCHOENHERR HEIKE, MOUSTAKAS DEMETRI T, KURUKULASURIYA RAVI, MADER MARY M, MCLEAN THOMAS H, AYAZ PELIN, TAYLOR ALEXANDER M, HUDSON BRANDI M, BOEZIO ALESSANDRO, SHARON DINA A
Year of Publication 19.01.2022
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Year of Publication 19.01.2022
Patent
PI3Kα 억제제 및 이의 사용 방법
WALTERS W. PATRICK, GELOZIA SHORENA, DENINNO MICHAEL PAUL, KURUKULASURIYA RAVI, LEE JESSICA, LEPITRE THOMAS, TAYLOR ALEXANDER M, BOEZIO ALESSANDRO, BURNIE ANDREW J, STURINO CLAUDIO, PIERCE LEVI CHARLES THOMAS, MOHAMED TAREK, THORAT RAKESH, KRUEGER ELAINE B, GIGUERE JEAN BENOIT, RAYNOR KEVIN DAVID, LARIVEE ALEXANDRE, LANDAGARAY ELODIE, CHEN FEI, PAL MOHAN, FRIDRICH CARY GRIFFIN, GUNAYDIN HAKAN, MAERTENS GAETAN, SHORTSLEEVES KELLEY C, MCLEAN THOMAS H, WANG QI, JOBIN DES LAURIERS ANTOINE, DIPIETRO LUCIAN V, PAN YUE, GIORDANETTO FABRIZIO, OUTIN JOHANNE, MADER MARY M, ATIENZA BREN JORDAN, BERTRAND LAPERLE MEGAN, VEMULA NARESH, TANVEER KASHIF, ZHANG HANMO, BOUSQUET YVES, LESCARBEAU ANDRE, TANG YONG, PECHERSKY YAKOV, CHITALE SAMPADA
Year of Publication 15.02.2023
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Year of Publication 15.02.2023
Patent