N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors
Bruncko, Milan, Tahir, Stephen K., Song, Xiaohong, Chen, Jun, Ding, Hong, Huth, Jeffrey R., Jin, Sha, Judge, Russell A., Madar, David J., Park, Chang H., Park, Cheol-Min, Petros, Andrew M., Tse, Christin, Rosenberg, Saul H., Elmore, Steven W.
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors
Longenecker, Kenton L, Stewart, Kent D, Madar, David J, Jakob, Clarissa G, Fry, Elizabeth H, Wilk, Sherwin, Lin, Chun W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Yong, Hong, Pireh, Daisy, Pei, Zhonghua, Basha, Fatima, Wiedeman, Paul E, von Geldern, Thomas W, Trevillyan, James M, Stoll, Vincent S
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Discovery of 2-[4-{{2-(2S,5R)-2-Cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic Acid (ABT-279): A Very Potent, Selective, Effective, and Well-Tolerated Inhibitor of Dipeptidyl Peptidase-IV, Useful for the Treatment of Diabetes
Madar, David J, Kopecka, Hana, Pireh, Daisy, Yong, Hong, Pei, Zhonghua, Li, Xiaofeng, Wiedeman, Paul E, Djuric, Stevan W, Von Geldern, Thomas W, Fickes, Michael G, Bhagavatula, Lakshmi, McDermott, Todd, Wittenberger, Steven, Richards, Steven J, Longenecker, Kenton L, Stewart, Kent D, Lubben, Thomas H, Ballaron, Stephen J, Stashko, Michael A, Long, Michelle A, Wells, Heidi, Zinker, Bradley A, Mika, Amanda K, Beno, David W. A, Kempf-Grote, Anita J, Polakowski, James, Segreti, Jason, Reinhart, Glenn A, Fryer, Ryan M, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Journal Article
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Backes, Bradley J., Longenecker, Kenton, Hamilton, Gregory L., Stewart, Kent, Lai, Chunqiu, Kopecka, Hana, von Geldern, Thomas W., Madar, David J., Pei, Zhonghua, Lubben, Thomas H., Zinker, Bradley A., Tian, Zhenping, Ballaron, Stephen J., Stashko, Michael A., Mika, Amanda K., Beno, David W.A., Kempf-Grote, Anita J., Black-Schaefer, Candace, Sham, Hing L., Trevillyan, James M.
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Journal Article
3,5-Bis(trifluoromethyl)pyrazoles: A Novel Class of NFAT Transcription Factor Regulator
Djuric, Stevan W, BaMaung, Nwe Y, Basha, Anwer, Liu, Huaqing, Luly, Jay R, Madar, David J, Sciotti, Richard J, Tu, Noah P, Wagenaar, Frank L, Wiedeman, Paul E, Zhou, Xun, Ballaron, Stephen, Bauch, Joy, Chen, Yung-Wu, Chiou, X. Grace, Fey, Thomas, Gauvin, Donna, Gubbins, Earl, Hsieh, Gin C, Marsh, Kennan C, Mollison, Karl W, Pong, Melissa, Shaughnessy, Thomas K, Sheets, Michael P, Smith, Morey, Trevillyan, James M, Warrior, Usha, Wegner, Craig D, Carter, George W
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction. Application to the synthesis of the antibacterial agent Dup-721
Madar, David J, Kopecka, Hana, Pireh, Daisy, Pease, Jonathan, Pliushchev, Marina, Sciotti, Richard J, Wiedeman, Paul E, Djuric, Stevan W
Published in Tetrahedron letters (28.05.2001)
Published in Tetrahedron letters (28.05.2001)
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Journal Article
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Journal Article
Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity
Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
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Insights into the Mechanism of DNA Cleavage by Dynemicin A as Revealed by DNA-Binding and -Cleavage Studies of Synthetic Analogs
Myers, Andrew G, Cohen, Scott B, Tom, Norma J, Madar, David J, Fraley, Mark E
Published in Journal of the American Chemical Society (01.07.1995)
Published in Journal of the American Chemical Society (01.07.1995)
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Journal Article
Correction to Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity
Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in Journal of medicinal chemistry (14.05.2015)
Published in Journal of medicinal chemistry (14.05.2015)
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Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S.C., Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R., Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L., Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Journal Article
Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements
Yeh, Vince S C, Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L, Link, J T
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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The Bcl-2 Family Inhibitor ABT-263 Shows Significant but Reversible Thrombocytopenia in Mice
Shoemaker, Alex R., Mitten, Michael J., Adickes, Jessica, Oleksijew, Anatol, Zhang, Haichao, Bauch, Joy, Marsh, Kennan, Frost, David J., Madar, David, Tse, Christin, Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Total Synthesis of (+)-Damavaricin D
Roush, William R., Coffey, D. Scott, Madar, David J.
Published in Journal of the American Chemical Society (19.11.1997)
Published in Journal of the American Chemical Society (19.11.1997)
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Journal Article
Synthesis of highly functionalized naphthoate precursors to damavaricin D Observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized β-naphthol derivatives
Roush, William R, Madar, David J, Coffey, D Scott
Published in Canadian journal of chemistry (01.11.2001)
Published in Canadian journal of chemistry (01.11.2001)
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Journal Article
Synthesis of highly functionalized naphthoate precursors to damavaricin D - observation of kinetically stable bezocyclohexadienones in the bromination reactions of highly functionalized
Roush, William R, Madar, David J, Coffey, D Scott
Published in Canadian journal of chemistry (01.11.2001)
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Published in Canadian journal of chemistry (01.11.2001)
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