Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates
Thi, Emily P., Mire, Chad E., Lee, Amy C. H., Geisbert, Joan B., Zhou, Joy Z., Agans, Krystle N., Snead, Nicholas M., Deer, Daniel J., Barnard, Trisha R., Fenton, Karla A., MacLachlan, Ian, Geisbert, Thomas W.
Published in Nature (London) (21.05.2015)
Published in Nature (London) (21.05.2015)
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Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
Judge, Adam D, Robbins, Marjorie, Tavakoli, Iran, Levi, Jasna, Hu, Lina, Fronda, Anna, Ambegia, Ellen, McClintock, Kevin, MacLachlan, Ian
Published in The Journal of clinical investigation (01.03.2009)
Published in The Journal of clinical investigation (01.03.2009)
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Genome-wide shifts in climate-related variation underpin responses to selective breeding in a widespread conifer
MacLachlan, Ian R., McDonald, Tegan K., Lind, Brandon M., Rieseberg, Loren H., Yeaman, Sam, Aitken, Sally N.
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (09.03.2021)
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Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids
Heyes, James, Palmer, Lorne, Bremner, Kaz, MacLachlan, Ian
Published in Journal of controlled release (03.10.2005)
Published in Journal of controlled release (03.10.2005)
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Journal Article
Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study
Geisbert, Thomas W, Prof, Lee, Amy CH, MSc, Robbins, Marjorie, PhD, Geisbert, Joan B, Honko, Anna N, PhD, Sood, Vandana, MSc, Johnson, Joshua C, BSc, de Jong, Susan, PhD, Tavakoli, Iran, BSc, Judge, Adam, PhD, Hensley, Lisa E, PhD, MacLachlan, Ian, PhD
Published in The Lancet (British edition) (29.05.2010)
Published in The Lancet (British edition) (29.05.2010)
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Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes
Judge, Adam, McClintock, Kevin, Phelps, Janet R, Maclachlan, Ian
Published in Molecular therapy (01.02.2006)
Published in Molecular therapy (01.02.2006)
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Growth gains from selective breeding in a spruce hybrid zone do not compromise local adaptation to climate
MacLachlan, Ian R., Yeaman, Sam, Aitken, Sally N.
Published in Evolutionary applications (01.02.2018)
Published in Evolutionary applications (01.02.2018)
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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
Robbins, Marjorie, Judge, Adam, Ambegia, Ellen, Choi, Catherine, Yaworski, Ed, Palmer, Lorne, McClintock, Kevin, MacLachlan, Ian
Published in Human gene therapy (01.10.2008)
Published in Human gene therapy (01.10.2008)
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Antitumor Effects in Hepatocarcinoma of Isoform-Selective Inhibition of HDAC2
LEE, Yun-Han, DAEKWAN SEO, CONNER, Elizabeth A, MACLACHLAN, Ian, FACTOR, Valentina M, THORGEIRSSON, Snorri S, CHOI, Kyung-Ju, ANDERSEN, Jesper B, WON, Min-Ah, KITADE, Mitsuteru, GOMEZ-QUIROZ, Luis E, JUDGE, Adam D, MARQUARDT, Jens U, RAGGI, Chiara
Published in Cancer research (Chicago, Ill.) (01.09.2014)
Published in Cancer research (Chicago, Ill.) (01.09.2014)
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Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA
Thi, Emily P, Mire, Chad E, Ursic-Bedoya, Raul, Geisbert, Joan B, Lee, Amy C H, Agans, Krystle N, Robbins, Marjorie, Deer, Daniel J, Fenton, Karla A, MacLachlan, Ian, Geisbert, Thomas W
Published in Science translational medicine (20.08.2014)
Published in Science translational medicine (20.08.2014)
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A scalable, extrusion-free method for efficient liposomal encapsulation of plasmid DNA
Jeffs, Lloyd B, Palmer, Lorne R, Ambegia, Ellen G, Giesbrecht, Cory, Ewanick, Shannon, MacLachlan, Ian
Published in Pharmaceutical research (01.03.2005)
Published in Pharmaceutical research (01.03.2005)
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Journal Article
Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference
Geisbert, Thomas W., Hensley, Lisa E., Kagan, Elliott, Yu, Erik Zhaoying, Geisbert, Joan B., Daddario-DiCaprio, Kathleen, Fritz, Elizabeth A., Jahrling, Peter B., McClintock, Kevin, Phelps, Janet R., Lee, Amy C. H., Judge, Adam, Jeffs, Lloyd B., MacLachlan, Ian
Published in The Journal of Infectious Diseases (15.06.2006)
Published in The Journal of Infectious Diseases (15.06.2006)
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Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma
LEE, Yun-Han, ANDERSEN, Jesper B, HYUN GOO WOO, CONNER, Elizabeth A, AVITAL, Itzhak, MACLACHLAN, Ian, FACTOR, Valentina M, THORGEIRSSON, Snorri S, SONG, Ho-Taek, JUDGE, Adam D, SEO, Daekwan, ISHIKAWA, Tsuyoshi, MARQUARDT, Jens U, KITADE, Mitsuteru, DURKIN, Marian E, RAGGI, Chiara
Published in Cancer research (Chicago, Ill.) (01.11.2010)
Published in Cancer research (Chicago, Ill.) (01.11.2010)
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Journal Article
Lipid Encapsulation Enables the Effective Systemic Delivery of Polyplex Plasmid DNA
Heyes, James, Palmer, Lorne, Chan, Kitty, Giesbrecht, Cory, Jeffs, Lloyd, MacLachlan, Ian
Published in Molecular therapy (01.04.2007)
Published in Molecular therapy (01.04.2007)
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Conservation payments, off-farm employment and household welfare for farmers participating in the “Grain for Green” program in China
Li, Li, Tsunekawa, Atsushi, MacLachlan, Ian, Li, Guicai, Koike, Atsushi, Guo, Yuanyuan
Published in China agricultural economic review (10.01.2020)
Published in China agricultural economic review (10.01.2020)
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