Discovery of (7 R )-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6 H -indolo[1,2- e ][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase
Narjes, Frank, Crescenzi, Benedetta, Ferrara, Marco, Habermann, Jörg, Colarusso, Stefania, del Rosario Rico Ferreira, Maria, Stansfield, Ian, Mackay, Angela Claire, Conte, Immacolata, Ercolani, Caterina, Zaramella, Simone, Palumbi, Maria-Cecilia, Meuleman, Philip, Leroux-Roels, Geert, Giuliano, Claudio, Fiore, Fabrizio, Di Marco, Stefania, Baiocco, Paola, Koch, Uwe, Migliaccio, Giovanni, Altamura, Sergio, Laufer, Ralph, De Francesco, Raffaele, Rowley, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase
Narjes, Frank, Crescenzi, Benedetta, Ferrara, Marco, Habermann, Jörg, Colarusso, Stefania, del Rosario Rico Ferreira, Maria, Stansfield, Ian, Mackay, Angela Claire, Conte, Immacolata, Ercolani, Caterina, Zaramella, Simone, Palumbi, Maria-Cecilia, Meuleman, Philip, Leroux-Roels, Geert, Giuliano, Claudio, Fiore, Fabrizio, Di Marco, Stefania, Baiocco, Paola, Koch, Uwe, Migliaccio, Giovanni, Altamura, Sergio, Laufer, Ralph, De Francesco, Raffaele, Rowley, Michael
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
Get full text
Journal Article
Novel anti-viral macrocyclic indole compounds
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Year of Publication 21.09.2011
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Macrocyclic indole derivatives for the treatment of hepatitis C infections
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Macrocyclic indole derivatives for the treatment of hepatitis C infections
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Year of Publication 21.01.2009
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Year of Publication 21.01.2009
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Macrocyclic indole derivatives for the treatment of hepatitis c infections
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Year of Publication 10.07.2013
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Year of Publication 10.07.2013
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