Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa
Krause, Kevin M, Haglund, Cat M, Hebner, Christy, Serio, Alisa W, Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R, Machajewski, Timothy D, Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D, Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T
Published in Antimicrobial agents and chemotherapy (01.11.2019)
Published in Antimicrobial agents and chemotherapy (01.11.2019)
Get full text
Journal Article
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety
Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.
Published in ChemMedChem (20.08.2019)
Published in ChemMedChem (20.08.2019)
Get full text
Journal Article
Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors
Renhowe, Paul A, Pecchi, Sabina, Shafer, Cynthia M, Machajewski, Timothy D, Jazan, Elisa M, Taylor, Clarke, Antonios-McCrea, William, McBride, Christopher M, Frazier, Kelly, Wiesmann, Marion, Lapointe, Gena R, Feucht, Paul H, Warne, Robert L, Heise, Carla C, Menezes, Daniel, Aardalen, Kimberly, Ye, Helen, He, Molly, Le, Vincent, Vora, Jayesh, Jansen, Johanna M, Wernette-Hammond, Mary Ellen, Harris, Alex L
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
Get full text
Journal Article
Glycosylation of Threonine of the Repeating Unit of RNA Polymerase II with β-Linked N-Acetylglucosame Leads to a Turnlike Structure
Simanek, Eric E, Huang, Dee-Hua, Pasternack, Laura, Machajewski, Timothy D, Seitz, Oliver, Millar, David S, Dyson, H. Jane, Wong, Chi-Huey
Published in Journal of the American Chemical Society (18.11.1998)
Published in Journal of the American Chemical Society (18.11.1998)
Get full text
Journal Article
The Catalytic Asymmetric Aldol Reaction
Machajewski, Timothy D., Wong, Chi-Huey
Published in Angewandte Chemie International Edition (17.04.2000)
Published in Angewandte Chemie International Edition (17.04.2000)
Get full text
Journal Article
METHODS OF TREATING CANCER AND RELATED METHODS
HANNAH ALISON, VORA JAYESH, HAROLDSEN PETER, ZHU SHUGUANG, MACHAJEWSKI TIMOTHY D, HEISE CARLA C, HARWOOD ERIC, SAMARA EMIL, SHANG XIAO
Year of Publication 05.10.2011
Get full text
Year of Publication 05.10.2011
Patent
NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF
MACHAJEWSKI TIMOTHY D, MCKENNA MAUREEN, SENDZIK MARTIN, ZHANG QIONG, ANTONIOS MCCREA WILLIAM R, POON DANIEL, HUANG ZILIN, JIN JEFF, XU YONGJIN, SHAFER CYNTHIA M, RENHOWE PAUL A, SMITH AARON
Year of Publication 23.04.2013
Get full text
Year of Publication 23.04.2013
Patent
NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF
MACHAJEWSKI TIMOTHY D, MCKENNA MAUREEN, SENDZIK MARTIN, ZHANG QIONG, ANTONIOS MCCREA WILLIAM R, POON DANIEL, HUANG ZILIN, JIN JEFF, XU YONGJIN, SHAFER CYNTHIA M, RENHOWE PAUL A, SMITH AARON
Year of Publication 28.12.2010
Get full text
Year of Publication 28.12.2010
Patent
ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF
MUNOZ, Manuel Angel, MACHAJEWSKI, Timothy D, LEFTHERIS, Katerina, MONTELEONE, Dennis, HOM, Timothy F, FINKELSTEIN, Darren
Year of Publication 02.08.2024
Get full text
Year of Publication 02.08.2024
Patent
ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF
MUNOZ, Manuel Angel, MACHAJEWSKI, Timothy D, LEFTHERIS, Katerina, MONTELEONE, Dennis, HOM, Timothy F, FINKELSTEIN, Darren
Year of Publication 25.07.2024
Get full text
Year of Publication 25.07.2024
Patent
ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF
MUNOZ, Manuel Angel, MACHAJEWSKI, Timothy D, LEFTHERIS, Katerina, MONTELEONE, Dennis, HOM, Timothy F, FINKELSTEIN, Darren
Year of Publication 04.07.2024
Get full text
Year of Publication 04.07.2024
Patent
LHMDS mediated tandem acylation–cyclization of 2-aminobenzenecarbonitriles with 2-benzymidazol-2-yl acetates: a short and efficient route to the synthesis of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones
Antonios-McCrea, William R., Frazier, Kelly A., Jazan, Elisa M., Machajewski, Timothy D., McBride, Christopher M., Pecchi, Sabina, Renhowe, Paul A., Shafer, Cynthia M., Taylor, Clarke
Published in Tetrahedron letters (30.01.2006)
Published in Tetrahedron letters (30.01.2006)
Get full text
Journal Article
compostos heterocíclicos e usos dos mesmos
Maureen Mckenna, Jeff Jin, Martin Sendzik, Aaron Smith, William Anotnio-Mccrea, Daniel Poon, Paul A. Renhowe, Yongjin Xu, Cynthia M. Shafer, Qiong Zhang, Timothy D. Machajewski, Zilin Huang
Year of Publication 24.09.2019
Get full text
Year of Publication 24.09.2019
Patent
ANTIBACTERIAL AGENTS
HILDEBRANDT, Darin James, KONRADI, Andrei W, MACHAJEWSKI, Timothy D, CHOI, Taylor Ann Joo, COHEN, Frederick, KANE, Timothy Robert
Year of Publication 28.12.2017
Get full text
Year of Publication 28.12.2017
Patent
Pharmaceutically acceptable salts of quinolinone compounds and their medical use
RYCKMAN, DAVID, CAI, SHAOPEI, SHANG, XIAO, HARWOOD, ERIC, OKHAMAFE, AUGUSTUS, MACHAJEWSKI, TIMOTHY D, CHOU, JOYCE, ZHU, SHUGUANG, TESCONI, MARC
Year of Publication 06.08.2014
Get full text
Year of Publication 06.08.2014
Patent