NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes
Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
Get full text
Journal Article
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity
Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.
Published in Bioorganic & medicinal chemistry (15.07.2022)
Published in Bioorganic & medicinal chemistry (15.07.2022)
Get full text
Journal Article
Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction
Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
Get full text
Journal Article
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
Get full text
Journal Article
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
Get full text
Journal Article
A Poly(p-phenyleneethynylene) with a Highly Emissive Aggregated Phase
Deans, Robert, Kim, Jinsang, Machacek, Michelle R, Swager, Timothy M
Published in Journal of the American Chemical Society (06.09.2000)
Published in Journal of the American Chemical Society (06.09.2000)
Get full text
Journal Article
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors
Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
Get full text
Journal Article
Update on lymphocyte specific kinase inhibitors: a patent survey
Martin, Matthew W, Machacek, Michelle R
Published in Expert opinion on therapeutic patents (01.11.2010)
Published in Expert opinion on therapeutic patents (01.11.2010)
Get more information
Journal Article
An Efficient One-Pot Enantio- and Diastereoselective Synthesis of Heterocycles
Trost, Barry M., Machacek, Michelle R.
Published in Angewandte Chemie (International ed.) (16.12.2002)
Published in Angewandte Chemie (International ed.) (16.12.2002)
Get full text
Journal Article
Racemic Synthesis of a Key 1,4-Dihydro‑2H‑spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block
Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.
Published in Organic process research & development (18.11.2022)
Published in Organic process research & development (18.11.2022)
Get full text
Journal Article
Racemic Synthesis of a Key 1,4-Dihydro-2 H -spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block
Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.
Published in Organic process research & development (18.11.2022)
Published in Organic process research & development (18.11.2022)
Get full text
Journal Article
Identification of free fatty acid receptor 2 agonists using virtual screening
Fells, James I., Ai, Xi, Weinglass, Adam, Feng, Wen, Lei, Ying, Finley, Michael, Hoveyda, Hamid R., Fraser, Graeme L., Machacek, Michelle
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Get full text
Journal Article
Abstract LB-029: Identification of predictive genetic signatures of Cytarabine responsiveness in acute myeloid leukemia using a novel 3D translational culture model of primary bone marrow
Xu, Haiyan, Muise, Eric S., Javaid, Sarah, Chen, Lan, Cristescu, Razvan, Mansueto, My Sam, Follmer, Nicole, Cho, Jennifer, Kerr, Kimberley, Altura, Rachel, Machacek, Michelle, Nicholson, Benjamin, Addona, George, Kariv, Ilona, Chen, Hongmin
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
PRMT5 억제제
KAWAMURA SHUHEI, WITTER DAVID J, MACHACEK MICHELLE, ALTMAN MICHAEL D, GIBEAU CRAIG R, SLOMAN DAVID L
Year of Publication 17.08.2022
Get full text
Year of Publication 17.08.2022
Patent
Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model
Xu, Haiyan, Muise, Eric S., Javaid, Sarah, Chen, Lan, Cristescu, Razvan, Mansueto, My Sam, Follmer, Nicole, Cho, Jennifer, Kerr, Kimberley, Altura, Rachel, Machacek, Michelle, Nicholson, Benjamin, Addona, George, Kariv, Ilona, Chen, Hongmin
Published in Journal of cellular and molecular medicine (01.10.2019)
Published in Journal of cellular and molecular medicine (01.10.2019)
Get full text
Journal Article