An Efficient One-Pot Enantio- and Diastereoselective Synthesis of Heterocycles
Trost, Barry M., Machacek, Michelle R.
Published in Angewandte Chemie International Edition (16.12.2002)
Published in Angewandte Chemie International Edition (16.12.2002)
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Journal Article
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity
Kawamura, Shuhei, Palte, Rachel L., Kim, Hai-Young, Saurí, Josep, Sondey, Christopher, Mansueto, My S., Altman, Michael D., Machacek, Michelle R.
Published in Bioorganic & medicinal chemistry (15.07.2022)
Published in Bioorganic & medicinal chemistry (15.07.2022)
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Journal Article
NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes
Fradera, Xavier, Reutershan, Michael H., Machacek, Michelle R., Trotter, B. Wesley, McCoy, Mark A.
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
Published in Chembiochem : a European journal of chemical biology (18.03.2022)
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Journal Article
Discovery of MK-4688: an Efficient Inhibitor of the HDM2–p53 Protein–Protein Interaction
Reutershan, Michael H, Machacek, Michelle R, Altman, Michael D, Bogen, Stephane, Cai, Mingmei, Cammarano, Carolyn, Chen, Dapeng, Christopher, Matthew, Cryan, John, Daublain, Pierre, Fradera, Xavier, Geda, Prasanthi, Goldenblatt, Peter, Hill, Armetta D, Kemper, Raymond A, Kutilek, Victoria, Li, Chaomin, Martinez, Michelle, McCoy, Mark, Nair, Latha, Pan, Weidong, Thompson, Christopher F, Scapin, Giovanna, Shizuka, Manami, Spatz, Marianne L, Steinhuebel, Dietrich, Sun, Binyuan, Voss, Matthew E, Wang, Xiao, Yang, Liping, Yeh, Tammie C, Dussault, Isabelle, Marshall, C. Gary, Trotter, B. Wesley
Published in Journal of medicinal chemistry (11.11.2021)
Published in Journal of medicinal chemistry (11.11.2021)
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Journal Article
The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
Quiroz, Ryan V, Reutershan, Michael H, Schneider, Sebastian E, Sloman, David, Lacey, Brian M, Swalm, Brooke M, Yeung, Charles S, Gibeau, Craig, Spellman, Daniel S, Rankic, Danica A, Chen, Dapeng, Witter, David, Linn, Doug, Munsell, Erik, Feng, Guo, Xu, Haiyan, Hughes, Jonathan M. E, Lim, Jongwon, Saurí, Josep, Geddes, Kristin, Wan, Murray, Mansueto, My Sam, Follmer, Nicole E, Fier, Patrick S, Siliphaivanh, Phieng, Daublain, Pierre, Palte, Rachel L, Hayes, Robert P, Lee, Sandra, Kawamura, Shuhei, Silverman, Steven, Sanyal, Sulagna, Henderson, Timothy J, Ye, Yingchun, Gao, Yuanwei, Nicholson, Benjamin, Machacek, Michelle R
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Journal Article
Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)
Palte, Rachel L, Schneider, Sebastian E, Altman, Michael D, Hayes, Robert P, Kawamura, Shuhei, Lacey, Brian M, Mansueto, My Sam, Reutershan, Michael, Siliphaivanh, Phieng, Sondey, Christopher, Xu, Haiyan, Xu, Zangwei, Ye, Yingchun, Machacek, Michelle R
Published in ACS medicinal chemistry letters (10.09.2020)
Published in ACS medicinal chemistry letters (10.09.2020)
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Journal Article
A Poly(p-phenyleneethynylene) with a Highly Emissive Aggregated Phase
Deans, Robert, Kim, Jinsang, Machacek, Michelle R, Swager, Timothy M
Published in Journal of the American Chemical Society (06.09.2000)
Published in Journal of the American Chemical Society (06.09.2000)
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Journal Article
Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors
Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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Journal Article
Update on lymphocyte specific kinase inhibitors: a patent survey
Martin, Matthew W, Machacek, Michelle R
Published in Expert opinion on therapeutic patents (01.11.2010)
Published in Expert opinion on therapeutic patents (01.11.2010)
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Journal Article
Racemic Synthesis of a Key 1,4-Dihydro‑2H‑spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block
Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.
Published in Organic process research & development (18.11.2022)
Published in Organic process research & development (18.11.2022)
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Journal Article
Racemic Synthesis of a Key 1,4-Dihydro-2 H -spiro[isoquinoline-3,4′-piperidin]-3′-ol Building Block
Candito, David A., Martinot, Theodore A., Su, Jing, Saurí, Josep, Lam, Yu-hong, Joyce, Leo A., Silverman, Steven M., Sloman, David L., Maddess, Matthew L., Machacek, Michelle R.
Published in Organic process research & development (18.11.2022)
Published in Organic process research & development (18.11.2022)
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Journal Article
AMINOPYRIMIDINES AS SYK INHIBITORS
DONOFRIO ANTHONY, GUAY DANIEL, DI FRANCESCO MARIA EMILIA, ZHOU HUA, CHILDERS KALEEN KONRAD, KNOWLES SANDRA LEE, SCHELL ADAM J, SPENCER KERRIE B, ALTMAN MICHAEL D, TAOKA BRANDON M, ANDRESEN BRIAN M, O'BOYLE BRENDAN M, GAUTHIER JACQUES YVES, REUTERSHAN MICHAEL H, HAIDLE ANDREW M, TROTTER B. WESLEY, OTTE RYAN D, GUERIN DAVID JOSEPH, BHAT SATHESH, PETROCCHI ALESSIA, SIU TONY, LI CHAOMIN, DUPONT GAUDET KRISTINA, MACHACEK MICHELLE R, WOO, HYUN CHONG, COTE BERNARD, GRIMM JONATHAN, ARRINGTON KENNETH L, ROBICHAUD JOEL S, KATTAR SOLOMON, MADDESS MATTHEW L, ROMEO ERIC, BURCH JASON, FOURNIER JEAN FRANCOIS, ELLIS JOHN MICHAEL, LIM, JONG WON, FISCHER CHRISTIAN, NORTHRUP ALAN B
Year of Publication 04.09.2012
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Year of Publication 04.09.2012
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