Immunosuppressive and Anti-angiogenic Sphingosine 1-Phosphate Receptor-1 Agonists Induce Ubiquitinylation and Proteasomal Degradation of the Receptor
Oo, Myat Lin, Thangada, Shobha, Wu, Ming-Tao, Liu, Catherine H., Macdonald, Timothy L., Lynch, Kevin R., Lin, Chen-Yong, Hla, Timothy
Published in The Journal of biological chemistry (23.03.2007)
Published in The Journal of biological chemistry (23.03.2007)
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Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate
Kharel, Yugesh, Mathews, Thomas P, Gellett, Amanda M, Tomsig, Jose L, Kennedy, Perry C, Moyer, Morgan L, Macdonald, Timothy L, Lynch, Kevin R
Published in Biochemical journal (15.12.2011)
Published in Biochemical journal (15.12.2011)
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Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury
BAJWA, Amandeep, JO, Sang-Kyung, HONG YE, LIPING HUANG, DONDETI, Krishna R, ROSIN, Diane L, HAASE, Volker H, MACDONALD, Timothy L, LYNCH, Kevin R, OKUSA, Mark D
Published in Journal of the American Society of Nephrology (01.06.2010)
Published in Journal of the American Society of Nephrology (01.06.2010)
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Sphingosine 1-Phosphate Analogs as Receptor Antagonists
Davis, Michael D., Clemens, Jeremy J., Macdonald, Timothy L., Lynch, Kevin R.
Published in The Journal of biological chemistry (18.03.2005)
Published in The Journal of biological chemistry (18.03.2005)
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Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
Cross, Janet V, Rady, Joshua M, Foss, Frank W, Lyons, Charles E, Macdonald, Timothy L, Templeton, Dennis J
Published in Biochemical journal (12.10.2009)
Published in Biochemical journal (12.10.2009)
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Development of Amidine-Based Sphingosine Kinase 1 Nanomolar Inhibitors and Reduction of Sphingosine 1-Phosphate in Human Leukemia Cells
Kennedy, Andrew J, Mathews, Thomas P, Kharel, Yugesh, Field, Saundra D, Moyer, Morgan L, East, James E, Houck, Joseph D, Lynch, Kevin R, Macdonald, Timothy L
Published in Journal of medicinal chemistry (26.05.2011)
Published in Journal of medicinal chemistry (26.05.2011)
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Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney
Awad, Alaa S, Ye, Hong, Huang, Liping, Li, Li, Foss, Jr, Frank W, Macdonald, Timothy L, Lynch, Kevin R, Okusa, Mark D
Published in American journal of physiology. Renal physiology (01.06.2006)
Published in American journal of physiology. Renal physiology (01.06.2006)
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Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model
WARREN, Cirle A, VAN OPSTAL, Edward, MACDONALD, Timothy L, HOFFMAN, Paul S, BALLARD, T. Eric, KENNEDY, Andrew, XIA WANG, RIGGINS, Mary, OLEKHNOVICH, Igor, WARTHAN, Michelle, KOLLING, Glynis L, GUERRANT, Richard L
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
Published in Antimicrobial Agents and Chemotherapy (01.08.2012)
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Sphingosine-1 Phosphate Prevents Monocyte/Endothelial Interactions in Type 1 Diabetic NOD Mice Through Activation of the S1P1 Receptor
Whetzel, Angela M, Bolick, David T, Srinivasan, Suseela, Macdonald, Timothy L, Morris, Margaret A, Ley, Klaus, Hedrick, Catherine C
Published in Circulation research (29.09.2006)
Published in Circulation research (29.09.2006)
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Discovery, Biological Evaluation, and Structure−Activity Relationship of Amidine Based Sphingosine Kinase Inhibitors
Mathews, Thomas P, Kennedy, Andrew J, Kharel, Yugesh, Kennedy, Perry C, Nicoara, Oana, Sunkara, Manjula, Morris, Andrew J, Wamhoff, Brian R, Lynch, Kevin R, Macdonald, Timothy L
Published in Journal of medicinal chemistry (08.04.2010)
Published in Journal of medicinal chemistry (08.04.2010)
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Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720
Kharel, Yugesh, Lee, Sangderk, Snyder, Ashley H., Sheasley-O'Neill, Stacey L., Morris, Margaret A., Setiady, Yulius, Zhu, Ran, Zigler, Molly A., Burcin, Tracy L., Ley, Klaus, Tung, Kenneth S.K., Engelhard, Victor H., Macdonald, Timothy L., Pearson-White, Sonia, Lynch, Kevin R.
Published in The Journal of biological chemistry (04.11.2005)
Published in The Journal of biological chemistry (04.11.2005)
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Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells
Gaetano, Cristoforo G., Samadi, Nasser, Tomsig, Jose L., Macdonald, Timothy L., Lynch, Kevin R., Brindley, David N.
Published in Molecular carcinogenesis (01.09.2009)
Published in Molecular carcinogenesis (01.09.2009)
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Characterization of a sphingosine 1-phosphate receptor antagonist prodrug
Kennedy, Perry C, Zhu, Ran, Huang, Tao, Tomsig, Jose L, Mathews, Thomas P, David, Marion, Peyruchaud, Olivier, Macdonald, Timothy L, Lynch, Kevin R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
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Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles
Houck, Joseph D, Dawson, Thomas K, Kennedy, Andrew J, Kharel, Yugesh, Naimon, Niels D, Field, Saundra D, Lynch, Kevin R, Macdonald, Timothy L
Published in ACS medicinal chemistry letters (12.05.2016)
Published in ACS medicinal chemistry letters (12.05.2016)
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Synthesis and structure–activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein
Jain, Hiteshkumar D., Zhang, Chunchun, Zhou, Shuo, Zhou, Hao, Ma, Jun, Liu, Xiaoxiang, Liao, Xuebin, Deveau, Amy M., Dieckhaus, Christine M., Johnson, Michael A., Smith, Kirsten S., Macdonald, Timothy L., Kakeya, Hideaki, Osada, Hiroyuki, Cook, James M.
Published in Bioorganic & medicinal chemistry (15.04.2008)
Published in Bioorganic & medicinal chemistry (15.04.2008)
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Nitazoxanide Inhibits Biofilm Formation by Staphylococcus epidermidis by Blocking Accumulation on Surfaces
Tchouaffi-Nana, Florence, Ballard, T Eric, Cary, Christine H, Macdonald, Timothy L, Sifri, Costi D, Hoffman, Paul S
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
Published in Antimicrobial Agents and Chemotherapy (01.07.2010)
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Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors
Cui, Peng, Tomsig, Jose L., McCalmont, William F., Lee, Sangderk, Becker, Christopher J., Lynch, Kevin R., Macdonald, Timothy L.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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S-Nitrosothiol Depletion in Amyotrophic Lateral Sclerosis
Schonhoff, Christopher M., Matsuoka, Masaaki, Tummala, Hemachand, Johnson, Michael A., Estevéz, Alvaro G., Wu, Rui, Kamaid, Andrés, Ricart, Karina C., Hashimoto, Yuichi, Gaston, Benjamin, Macdonald, Timothy L., Xu, Zuoshang, Mannick, Joan B.
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (14.02.2006)
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