Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes
Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
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Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
Murphy, Andrew J., Macdonald, Lynn E., Stevens, Sean, Karow, Margaret, Dore, Anthony T., Pobursky, Kevin, Huang, Tammy T., Poueymirou, William T., Esau, Lakeisha, Meola, Melissa, Mikulka, Warren, Krueger, Pamela, Fairhurst, Jeanette, Valenzuela, David M., Papadopoulos, Nicholas, Yancopoulos, George D.
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (08.04.2014)
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Humanized mouse model supports development, function, and tissue residency of human natural killer cells
Herndler-Brandstetter, Dietmar, Shan, Liang, Yao, Yi, Stecher, Carmen, Plajer, Valerie, Lietzenmayer, Melanie, Strowig, Till, de Zoete, Marcel R., Palm, Noah W., Chen, Jie, Blish, Catherine A., Frleta, Davor, Gurer, Cagan, Macdonald, Lynn E., Murphy, Andrew J., Yancopoulos, George D., Montgomery, Ruth R., Flavell, Richard A.
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (07.11.2017)
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Accumulation of high molecular weight kininogen in the brains of Alzheimer's disease patients may affect microglial function by altering phagocytosis and lysosomal cathepsin activity
Zamolodchikov, Daria, Duffield, Michael, Macdonald, Lynn E., Alessandri‐Haber, Nicole
Published in Alzheimer's & dementia (01.10.2022)
Published in Alzheimer's & dementia (01.10.2022)
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Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice
Gillis, Caitlin M., BSci, Jönsson, Friederike, PhD, Mancardi, David A., PhD, Tu, Naxin, PhD, Beutier, Héloïse, PharmD, Van Rooijen, Nico, PhD, Macdonald, Lynn E., PhD, Murphy, Andrew J., PhD, Bruhns, Pierre, PhD
Published in Journal of allergy and clinical immunology (01.04.2017)
Published in Journal of allergy and clinical immunology (01.04.2017)
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Pharmacological inhibition of NPY receptors illustrates dissociable features of experimental colitis in the mouse DSS model: Implications for preclinical evaluation of efficacy in an inflammatory bowel disease model
Ruiz, Henry H, Becker, Stephanie, Bai, Yu, Cortes-Burgos, Luz A, Eckersdorff, Melissa M, Macdonald, Lynn E, Croll, Susan D
Published in PloS one (01.08.2019)
Published in PloS one (01.08.2019)
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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George
Published in Nature communications (06.11.2019)
Published in Nature communications (06.11.2019)
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IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice
Todorova, Biliana, Godon, Ophélie, Conde, Eva, Gillis, Caitlin M., Iannascoli, Bruno, Richard-Le Goff, Odile, Fiole, Daniel, Roumenina, Lubka T., Leusen, Jeanette H. W., Murphy, Andrew J., Macdonald, Lynn E., Reber, Laurent L., Jönsson, Friederike, Bruhns, Pierre
Published in The Journal of immunology (1950) (01.10.2022)
Published in The Journal of immunology (1950) (01.10.2022)
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Sustained Increases in Immune Transcripts and Immune Cell Trafficking During the Recovery of Experimental Brain Ischemia
Fury, Wen, Park, Keun Woo, Wu, Zhuhao, Kim, Eunhee, Woo, Moon-sook, Bai, Yu, Macdonald, Lynn E, Croll, Susan D, Cho, Sunghee
Published in Stroke (1970) (01.08.2020)
Published in Stroke (1970) (01.08.2020)
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Evaluation of the capacities of mouse TCR profiling from short read RNA-seq data
Bai, Yu, Wang, David, Li, Wentian, Huang, Ying, Ye, Xuan, Waite, Janelle, Barry, Thomas, Edelmann, Kurt H, Levenkova, Natasha, Guo, Chunguang, Skokos, Dimitris, Wei, Yi, Macdonald, Lynn E, Fury, Wen
Published in PloS one (15.11.2018)
Published in PloS one (15.11.2018)
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors
Balbino, Bianca, Herviou, Pauline, Godon, Ophélie, Stackowicz, Julien, Goff, Odile Richard-Le, Iannascoli, Bruno, Sterlin, Delphine, Brûlé, Sébastien, Millot, Gael A, Harris, Faith M, Voronina, Vera A, Nadeau, Kari C, Macdonald, Lynn E, Murphy, Andrew J, Bruhns, Pierre, Reber, Laurent L
Published in The Journal of clinical investigation (02.03.2020)
Published in The Journal of clinical investigation (02.03.2020)
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Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
Prissette, Marine, Fury, Wen, Koss, Matthew, Racioppi, Claudia, Fedorova, Daria, Dragileva, Ella, Clarke, Georgia, Pohl, Taylor, Dugan, John, Ahrens, Diana, Chiu, Joyce, Hunt, Charleen, Siao, Chia-Jen, Young, Tara, Bhowmick, Arijit, Rogulin, Vitaliy, Desclaux, Mathieu, Hayden, Eric Y., Podgorski, Michael, Gao, Min, Macdonald, Lynn E., Frendewey, David, Yancopoulos, George D., Zambrowicz, Brian
Published in Cell reports (Cambridge) (23.08.2022)
Published in Cell reports (Cambridge) (23.08.2022)
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A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain
Zamolodchikov, Daria, Bai, Yu, Tang, Yajun, McWhirter, John R., Macdonald, Lynn E., Alessandri-Haber, Nicole
Published in Neuroscience (10.08.2019)
Published in Neuroscience (10.08.2019)
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Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
Anderson, Keith D, Pan, Li, Yang, Xiao-man, Hughes, Virginia C, Walls, Johnathon R, Dominguez, Melissa G, Simmons, Mary V, Burfeind, Patricia, Xue, Yingzi, Wei, Yi, Macdonald, Lynn E, Thurston, Gavin, Daly, Christopher, Lin, Hsin Chieh, Economides, Aris N, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gale, Nicholas W
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.02.2011)
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Insight and Perspective From the Past
Foley, John T., MacDonald, Lynn C., Pratt, Erica
Published in Journal of physical education, recreation & dance (12.02.2023)
Published in Journal of physical education, recreation & dance (12.02.2023)
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A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity
Zhang, Wen, Hawkins, Peter G, He, Jing, Gupta, Namita T, Liu, Jinrui, Choonoo, Gabrielle, Jeong, Se W, Chen, Calvin R, Dhanik, Ankur, Dillon, Myles, Deering, Raquel, Macdonald, Lynn E, Thurston, Gavin, Atwal, Gurinder S
Published in Science advances (01.05.2021)
Published in Science advances (01.05.2021)
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Microenvironment-dependent growth of Sezary cells in humanized IL-15 mice
Gao, Jie, Ren, Shumei, Choonoo, Gabrielle, Chen, Guoying, Frleta, Davor, Zhong, Jun, Gupta, Namita, Sharma, Prachi, Oyejide, Adelekan, Atwal, Gurinder S., Macdonald, Lynn, Murphy, Andrew, Kuhnert, Frank
Published in Disease models & mechanisms (01.10.2023)
Published in Disease models & mechanisms (01.10.2023)
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Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct
Voronina, Vera A, Harris, Faith M, Schmahl, Jennifer, Galligan, Caryn, Oristian, Daniel, Zamfirova, Ralica, Gong, Guochun, Bai, Yu, Fury, Wen, Rajamani, Saathyaki, Walls, Johnathon R, Poueymirou, William T, Esau, Lakeisha, Gale, Nicholas W, Auerbach, Wojtek, Murphy, Andrew J, Macdonald, Lynn E
Published in Biology of reproduction (01.03.2019)
Published in Biology of reproduction (01.03.2019)
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Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence
Lee, Chang-Han, Kang, Tae Hyun, Godon, Ophélie, Watanabe, Makiko, Delidakis, George, Gillis, Caitlin M., Sterlin, Delphine, Hardy, David, Cogné, Michel, Macdonald, Lynn E., Murphy, Andrew J., Tu, Naxin, Lee, Jiwon, McDaniel, Jonathan R., Makowski, Emily, Tessier, Peter M., Meyer, Aaron S., Bruhns, Pierre, Georgiou, George
Published in Nature communications (26.11.2019)
Published in Nature communications (26.11.2019)
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