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TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype
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Published in Nature (London) (09.07.2015)
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Published in Blood (14.02.2019)
Published in Blood (14.02.2019)
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Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia
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Published in Leukemia (01.11.2019)
Published in Leukemia (01.11.2019)
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Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
Wang, Feng, Morita, Kiyomi, DiNardo, Courtney D., Furudate, Ken, Tanaka, Tomoyuki, Yan, Yuanqing, Patel, Keyur P., MacBeth, Kyle J., Wu, Bin, Liu, Guowen, Frattini, Mark, Matthews, Jairo A., Little, Latasha D., Gumbs, Curtis, Song, Xingzhi, Zhang, Jianhua, Thompson, Erika J., Kadia, Tapan M., Garcia-Manero, Guillermo, Jabbour, Elias, Ravandi, Farhad, Bhalla, Kapil N., Konopleva, Marina, Kantarjian, Hagop M., Andrew Futreal, P., Takahashi, Koichi
Published in Nature communications (10.05.2021)
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Pharmacokinetics and Pharmacodynamics with Extended Dosing of CC-486 in Patients with Hematologic Malignancies
Laille, Eric, Shi, Tao, Garcia-Manero, Guillermo, Cogle, Christopher R, Gore, Steven D, Hetzer, Joel, Kumar, Keshava, Skikne, Barry, MacBeth, Kyle J
Published in PloS one (21.08.2015)
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Randomized Phase III Study of Lenalidomide Versus Placebo in RBC Transfusion-Dependent Patients With Lower-Risk Non-del(5q) Myelodysplastic Syndromes and Ineligible for or Refractory to Erythropoiesis-Stimulating Agents
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Published in Journal of clinical oncology (01.09.2016)
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Phase I Study of Oral Azacitidine in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia
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Published in Journal of clinical oncology (20.06.2011)
Published in Journal of clinical oncology (20.06.2011)
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Cytogenetics and gene mutations influence survival in older patients with acute myeloid leukemia treated with azacitidine or conventional care
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Published in Leukemia (01.12.2018)
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Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome
Leung, Kevin K., Nguyen, Aaron, Shi, Tao, Tang, Lin, Ni, Xiaochun, Escoubet, Laure, MacBeth, Kyle J., DiMartino, Jorge, Wells, James A.
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2019)
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Randomised phase 2 study of pembrolizumab plus CC-486 versus pembrolizumab plus placebo in patients with previously treated advanced non-small cell lung cancer
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Published in European journal of cancer (1990) (01.02.2019)
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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
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p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)
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Published in Haematologica (Roma) (01.06.2014)
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Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia
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Combination of azacitidine and enasidenib enhances leukemic cell differentiation and cooperatively hypomethylates DNA
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Published in Experimental hematology (01.06.2021)
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Impact of somatic mutations on response to lenalidomide in lower-risk non-del(5q) myelodysplastic syndromes patients
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Published in Leukemia (01.03.2021)
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Enasidenib in patients with mutant IDH2 myelodysplastic syndromes: a phase 1 subgroup analysis of the multicentre, AG221-C-001 trial
Stein, Eytan M, Fathi, Amir T, DiNardo, Courtney D, Pollyea, Daniel A, Roboz, Gail J, Collins, Robert, Sekeres, Mikkael A, Stone, Richard M, Attar, Eyal C, Frattini, Mark G, Tosolini, Alessandra, Xu, Qiang, See, Wendy L, MacBeth, Kyle J, de Botton, Stéphane, Tallman, Martin S, Kantarjian, Hagop M
Published in The Lancet. Haematology (01.04.2020)
Published in The Lancet. Haematology (01.04.2020)
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Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes
Giagounidis, Aristoteles, Mufti, Ghulam J., Fenaux, Pierre, Germing, Ulrich, List, Alan, MacBeth, Kyle J.
Published in Annals of hematology (01.01.2014)
Published in Annals of hematology (01.01.2014)
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Abstract 2280: Functional characterization of combining epigenetic modifiers azacitidine and AG-221 in the TF-1:IDH2R140Q AML model
Chopra, Vivek S., Avanzino, Brian, Mavrommatis, Konstantinos, Olshen, Adam, DiMartino, Jorge, MacBeth, Kyle J.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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