PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow
Hopkins, Todd A, Ainsworth, William B, Ellis, Paul A, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Abraham, Vivek C, Algire, Mikkel A, Shi, Yan, Olson, Amanda M, Johnson, Eric F, Wilsbacher, Julie L, Maag, David
Published in Molecular cancer research (01.02.2019)
Published in Molecular cancer research (01.02.2019)
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Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors
Hopkins, Todd A, Shi, Yan, Rodriguez, Luis E, Solomon, Larry R, Donawho, Cherrie K, DiGiammarino, Enrico L, Panchal, Sanjay C, Wilsbacher, Julie L, Gao, Wenqing, Olson, Amanda M, Stolarik, DeAnne F, Osterling, Donald J, Johnson, Eric F, Maag, David
Published in Molecular cancer research (01.11.2015)
Published in Molecular cancer research (01.11.2015)
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Iniparib Nonselectively Modifies Cysteine-Containing Proteins in Tumor Cells and Is Not a Bona Fide PARP Inhibitor
XUESONG LIU, YAN SHI, XU, Allison J, LAYER, Ramesh, HARLAN, John E, SOLOMON, Larry R, DONAWHO, Cherrie K, PENNING, Thomas D, JOHNSON, Eric F, SHOEMAKER, Alexander R, MAAG, David X, PALMA, Joann P, PATTERSON, Melanie J, ELLIS, Paul A, SURBER, Bruce W, READY, Damien B, SONI, Niru B, LADROR, Uri S
Published in Clinical cancer research (15.01.2012)
Published in Clinical cancer research (15.01.2012)
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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Sweis, Ramzi F, Pliushchev, Marina, Brown, Peter J, Guo, Jun, Li, Fengling, Maag, David, Petros, Andrew M, Soni, Nirupama B, Tse, Chris, Vedadi, Masoud, Michaelides, Michael R, Chiang, Gary G, Pappano, William N
Published in ACS medicinal chemistry letters (13.02.2014)
Published in ACS medicinal chemistry letters (13.02.2014)
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Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1
Kim, Andrew Y., Tang, Zongxiang, Liu, Qin, Patel, Kush N., Maag, David, Geng, Yixun, Dong, Xinzhong
Published in Cell (02.05.2008)
Published in Cell (02.05.2008)
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The Eukaryotic Translation Initiation Factors eIF1 and eIF1A Induce an Open Conformation of the 40S Ribosome
Passmore, Lori A., Schmeing, T. Martin, Maag, David, Applefield, Drew J., Acker, Michael G., Algire, Mikkel A., Lorsch, Jon R., Ramakrishnan, V.
Published in Molecular cell (13.04.2007)
Published in Molecular cell (13.04.2007)
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Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase
Kim, Seyun, Kim, Sangwon F., Maag, David, Maxwell, Micah J., Resnick, Adam C., Juluri, Krishna R., Chakraborty, Anutosh, Koldobskiy, Michael A., Cha, Seung Hun, Barrow, Roxanne, Snowman, Adele M., Snyder, Solomon H.
Published in Cell metabolism (02.02.2011)
Published in Cell metabolism (02.02.2011)
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Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB
Maag, David, Maxwell, Micah J., Hardesty, Douglas A., Boucher, Katie L., Choudhari, Namrata, Hanno, Adam G., Ma, Jenny F., Snowman, Adele S., Pietropaoli, Joseph W., Xu, Risheng, Storm, Phillip B., Saiardi, Adolfo, Snyder, Solomon H., Resnick, Adam C.
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
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Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo
Cheung, Yuen-Nei, Maag, David, Mitchell, Sarah F, Fekete, Christie A, Algire, Mikkel A, Takacs, Julie E, Shirokikh, Nikolay, Pestova, Tatyana, Lorsch, Jon R, Hinnebusch, Alan G
Published in Genes & development (15.05.2007)
Published in Genes & development (15.05.2007)
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Discovery of A‑893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2
Sweis, Ramzi F., Wang, Zhi, Algire, Mikkel, Arrowsmith, Cheryl H., Brown, Peter J., Chiang, Gary G., Guo, Jun, Jakob, Clarissa G., Kennedy, Steven, Li, Fengling, Maag, David, Shaw, Bailin, Soni, Nirupama B., Vedadi, Masoud, Pappano, William N.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Matched cohort study of germline BRCA mutation carriers with triple negative breast cancer in brightness
Metzger-Filho, Otto, Collier, Katharine, Asad, Sarah, Ansell, Peter J., Watson, Mark, Bae, Junu, Cherian, Mathew, O’Shaughnessy, Joyce, Untch, Michael, Rugo, Hope S., Huober, Jens B., Golshan, Mehra, Sikov, William M., von Minckwitz, Gunter, Rastogi, Priya, Li, Lang, Cheng, Lijun, Maag, David, Wolmark, Norman, Denkert, Carsten, Symmans, W. Fraser, Geyer, Charles E., Loibl, Sibylle, Stover, Daniel G.
Published in NPJ breast cancer (11.11.2021)
Published in NPJ breast cancer (11.11.2021)
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Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition
Mustafa, Asif K, Rossum, Damian B. van, Patterson, Randen L, Maag, David, Ehmsen, Jeffrey T, Gazi, Sadia K, Chakraborty, Anutosh, Barrow, Roxanne K, Amzel, L. Mario, Snyder, Solomon H
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
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Development and characterization of a reconstituted yeast translation initiation system
ALGIRE, MIKKEL A., MAAG, DAVID, SAVIO, PETER, ACKER, MICHAEL G., TARUN, SALVADOR Z., SACHS, ALAN B., ASANO, KATSURA, NIELSEN, KLAUS H., OLSEN, DEANNE S., PHAN, LON, HINNEBUSCH, ALAN G., LORSCH, JON R.
Published in RNA (Cambridge) (01.03.2002)
Published in RNA (Cambridge) (01.03.2002)
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N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection
Fekete, Christie A, Mitchell, Sarah F, Cherkasova, Vera A, Applefield, Drew, Algire, Mikkel A, Maag, David, Saini, Adesh K, Lorsch, Jon R, Hinnebusch, Alan G
Published in The EMBO journal (21.03.2007)
Published in The EMBO journal (21.03.2007)
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Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase
Zhong, W, Ferrari, E, Lesburg, C A, Maag, D, Ghosh, S K, Cameron, C E, Lau, J Y, Hong, Z
Published in Journal of Virology (01.10.2000)
Published in Journal of Virology (01.10.2000)
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Intragenic Suppressor Mutations Restore GTPase and Translation Functions of a Eukaryotic Initiation Factor 5B Switch II Mutant
Shin, Byung-Sik, Acker, Michael G., Maag, David, Kim, Joo-Ran, Lorsch, Jon R., Dever, Thomas E.
Published in Molecular and Cellular Biology (01.03.2007)
Published in Molecular and Cellular Biology (01.03.2007)
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Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial
Diéras, Véronique, Han, Hyo S, Kaufman, Bella, Wildiers, Hans, Friedlander, Michael, Ayoub, Jean-Pierre, Puhalla, Shannon L, Bondarenko, Igor, Campone, Mario, Jakobsen, Erik H, Jalving, Mathilde, Oprean, Cristina, Palácová, Marketa, Park, Yeon Hee, Shparyk, Yaroslav, Yañez, Eduardo, Khandelwal, Nikhil, Kundu, Madan G, Dudley, Matthew, Ratajczak, Christine K, Maag, David, Arun, Banu K
Published in The lancet oncology (01.10.2020)
Published in The lancet oncology (01.10.2020)
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Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial
Loibl, Sibylle, O'Shaughnessy, Joyce, Untch, Michael, Sikov, William M, Rugo, Hope S, McKee, Mark D, Huober, Jens, Golshan, Mehra, von Minckwitz, Gunter, Maag, David, Sullivan, Danielle, Wolmark, Norman, McIntyre, Kristi, Ponce Lorenzo, Jose J, Metzger Filho, Otto, Rastogi, Priya, Symmans, W Fraser, Liu, Xuan, Geyer, Charles E
Published in The lancet oncology (01.04.2018)
Published in The lancet oncology (01.04.2018)
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