Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer
Li, Huiping, Song, Guohong, Zhou, Qiaoxia, Ran, Ran, Jiang, Hanfang, Zhang, Ruyan, Liu, Yaxin, Zhang, Jiayang, Meng, Luping, Ma, Liandong, Sun, Ye, Wang, Meiyu, Zhou, Qingqing, Yan, Honghua, Zhou, Qianxiang, Dong, Xunwei, Tong, Youzhi
Published in Breast cancer research and treatment (01.10.2021)
Published in Breast cancer research and treatment (01.10.2021)
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Journal Article
An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines
DAVIDSON, Jennifer D, LIANDONG MA, FLAGELLA, Michael, GEEGANAGE, Sandaruwan, GELBERT, Lawrence M, SLAPAK, Christopher A
Published in Cancer research (Chicago, Ill.) (01.06.2004)
Published in Cancer research (Chicago, Ill.) (01.06.2004)
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Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP-binding cassette (ABC) drug transporters
Dantzig, Anne H., Shepard, Robert L., Pratt, Susan E., Tabas, Linda B., Lander, Peter A., Ma, Liandong, Paul, Donald C., Williams, Daniel C., Peng, Sheng-Bin, Slapak, Christopher A., Godinot, Nathalie, Perry, William L.
Published in Biochemical pharmacology (15.03.2004)
Published in Biochemical pharmacology (15.03.2004)
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Journal Article
Identification and Characterization of the Canine Multidrug Resistance-associated Protein
Ma, Liandong, Pratt, Susan E, Cao, Jin, Dantzig, Anne H, Moore, Robert E, Slapak, Christopher A
Published in Molecular cancer therapeutics (01.12.2002)
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Published in Molecular cancer therapeutics (01.12.2002)
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Abstract 1265: Discovery of GT19077, a c-Myc/Max protein-protein Interaction (PPI) small molecule inhibitor, and GT19506 a c-Myc PROTAC molecule, for targeting c-Myc-driven blood cancers and small cell lung cancers
Ma, Liandong, Tong, Youzhi, Zhou, Qianxiang, Yang, Zhaohui, Yan, Honghau, Chen, Ye, Xu, Ruo, Pan, Jie, Gou, Xiaoqi, Qian, Weidong, Chen, Jie, Sun, Qi, Lai, Luhua
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53-Independent Cell Death in Acute Myeloid Leukemia and Lymphomas
Nishida, Yuki, Scruggs, Darah A, Ayoub, Edward, Patsilevas, Tallie, Ruvolo, Vivian, Mak, Po Yee, Carter, Bing Z, Boettcher, Steffen, Maiti, Abhishek, Zhou, Qianxiang, Yang, Zhaohui, Yan, Honghua, Ma, Liandong, Andreeff, Michael
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Abstract 3297: Discovery and evaluation of GT19870, a GSPT1/Myc molecular glue drug (MGD) with oral bioavailability for targeting c-Myc and n-Myc-addictive blood cancer and solid tumors
Ma, Liandong, Tong, Youzhi, Yang, Zhaohui, Zhou, Qiangxiang, Yan, Honghua, Xu, Ru, Chen, Dong
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract LB-111: GT19077, a c-Myc/Max protein-protein interaction (PPI) small molecule inhibitor, selectively targets c-Myc-additive B-cell and myeloid malignancies
Ma, Liandong, Tong, Youzhi, Yang, Zhaohui, Zhou, Qian Xiang, Chen, Jie, Chen, Ye, Bi, Honglei, Pan, Jie, Sun, Qi, Xu, Ru, Lai, Luhua
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A partially open conformation of an androgen receptor ligand‐binding domain with drug‐resistance mutations
Doamekpor, Selom K., Peng, Panfeng, Xu, Ruo, Ma, Liandong, Tong, Youzhi, Tong, Liang
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2023)
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2023)
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Journal Article
Proxalutamide reduces SARS-CoV-2 infection and associated inflammatory response
Qiao, Yuanyuan, Wotring, Jesse W, Zheng, Yang, Zhang, Charles J, Zhang, Yuping, Jiang, Xia, Pretto, Carla D, Eyunni, Sanjana, Parolia, Abhijit, He, Tongchen, Cheng, Caleb, Cao, Xuhong, Wang, Rui, Su, Fengyun, Ellison, Stephanie J, Wang, Yini, Qin, Jun, Yan, Honghua, Zhou, Qianxiang, Ma, Liandong, Sexton, Jonathan Z, Chinnaiyan, Arul M
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (25.07.2023)
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Abstract 3861: Proxalutamide (GT0918), a novel androgen receptor (AR) antagonist, targeting resistance mechanisms to AR signaling-directed castration-resistant prostate cancer (CRPC) therapies
Ma, Liandong, Zhou, Qianxiang, He, Yang, Chen, Jie, Zhou, Karl, Zhou, Qingqing, Chen, Chunyun, Xiang, Jason Shaoyun, Deng, Xiaobing, Lai, Luhua, Tong, Youzi
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 4978: Combination of a clinical stage-hedgehog inhibitor, GT1708, improves Venetoclax-induced apoptosis by down-regulating MCL-1 proteins in AML cells
Ma, Liandong, Zhou, Qianxiang, Yan, Honghua, Dong, Min, Han, Xiahe, Li, Jiangwie, Qu, Jie, Qian, Weidong, Tong, Youzhi
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas
Nishida, Yuki, Scruggs, Darah A, Ayoub, Edward, Patsilevas, Tallie, Ruvolo, Vivian R, Mak, Po Yee, Carter, Bing Z, Boettcher, Steffen, Maiti, Abhishek, Zhou, Qianxiang, Yang, Zhaohui, Yan, Honghua, Ma, Liandong, Andreeff, Michael
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Poster: AML-147 C-MYC Targeting by Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Exerts Profound Cell Kill In Vitro and In Vivo in Acute Myeloid Leukemia and Lymphomas
Nishida, Yuki, Scruggs, Darah A, Ayoub, Edward, Patsilevas, Tallie, Ruvolo, Vivian R, Mak, Po Yee, Carter, Bing Z, Boettcher, Steffen, Maiti, Abhishek, Zhou, Qianxiang, Yang, Zhaohui, Yan, Honghua, Ma, Liandong, Andreeff, Michael
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Abstract A03: Discovery and evaluation of GT19630, a c-Myc/n-Myc degrader, for targeting c-Myc-driven B-cell malignancies, acute myeloid leukemia (AML) and n-Myc driven cancers
Ma, Liandong, Tong, Yuzhi, Yang, Zhaohui, Zhou, Qianxiang, Yan, Honghua, Chen, Ye, Chen, Dong, Xu, Ru, Wang, Yini, Qin, Jun
Published in Blood cancer discovery (06.09.2022)
Published in Blood cancer discovery (06.09.2022)
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Abstract 5274: Mechanisms of action (MOA) for proxalutamide, an androgen receptor (AR) antagonist, for the treatment of mild, moderate and severe COVID-19 patients
Ma, Liandong, Tong, Youzhi, Zhou, Qianxiang, Yan, Hongha, Hou, Xiaodan, Ren, Zhiha, Li, Jiangwei, Wang, Huiyuan, Qian, Weidong, Zhang, Yu, Goren, Andy, Chinnaiyan, Arul
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract A31: C-MYC Targeting by Degradation: Novel Dual c-MYC/GSPT1 Degrader GT19715 Induces TP53-independent Cell Death in MYC-amplified Acute Myeloid Leukemia and Lymphomas
Nishida, Yuki, Scruggs, Darah A, Ayoub, Edward, Ostermann, Lauren B, Patsilevas, Tallie, Ruvolo, Vivian R, Mak, Po Yee, Carter, Bing Z., Boettcher, Steffen, Maiti, Abhishek, Sasaki, Koji, Zhou, Qianxiang, Yang, Zhaohui, Yan, Honghua, Ma, Liandong, Andreeff, Michael
Published in Blood cancer discovery (01.05.2023)
Published in Blood cancer discovery (01.05.2023)
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