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Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects
Yin, Wei, Mamashli, Fahimeh, Buhl, Derek L., Khudyakov, Polyna, Volfson, Dmitri, Martenyi, Ferenc, Gevorkyan, Hakop, Rosen, Laura, Simen, Arthur A.
Published in British journal of clinical pharmacology (01.02.2022)
Published in British journal of clinical pharmacology (01.02.2022)
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CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients
Cutolo, Maurizio, Soldano, Stefano, Gotelli, Emanuele, Montagna, Paola, Campitiello, Rosanna, Paolino, Sabrina, Pizzorni, Carmen, Sulli, Alberto, Smith, Vanessa, Tardito, Samuele
Published in Arthritis research & therapy (24.12.2021)
Published in Arthritis research & therapy (24.12.2021)
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Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages
Dube, Prabhatchandra R., Birnbaumer, Lutz, Vazquez, Guillermo
Published in Biochemical and biophysical research communications (09.09.2017)
Published in Biochemical and biophysical research communications (09.09.2017)
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Expanded characterization of in vitro polarized M0, M1, and M2 human monocyte-derived macrophages: Bioenergetic and secreted mediator profiles
Hickman, Elise, Smyth, Timothy, Cobos-Uribe, Catalina, Immormino, Robert, Rebuli, Meghan E., Moran, Timothy, Alexis, Neil E., Jaspers, Ilona
Published in PloS one (02.03.2023)
Published in PloS one (02.03.2023)
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Monocyte-derived and M1 macrophages from ankylosing spondylitis patients released higher TNF-α and expressed more IL1B in response to BzATP than macrophages from healthy subjects
Akhtari, Maryam, Zargar, Seyed Jalal, Vojdanian, Mahdi, Jamshidi, Ahmadreza, Mahmoudi, Mahdi
Published in Scientific reports (08.09.2021)
Published in Scientific reports (08.09.2021)
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C C chemokine ligand 3 deficiency ameliorates diet-induced steatohepatitis by regulating liver macrophage recruitment and M1/M2 status in mice
Xu, Liang, Chen, Yongping, Nagashimada, Mayumi, Ni, Yinhua, Zhuge, Fen, Chen, Guanliang, Li, Haoran, Pan, Tongtong, Yamashita, Tatsuya, Mukaida, Naofumi, Kaneko, Shuichi, Ota, Tsuguhito, Nagata, Naoto
Published in Metabolism, clinical and experimental (01.12.2021)
Published in Metabolism, clinical and experimental (01.12.2021)
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Pharmacokinetic and pharmacodynamic similarity evaluation between an insulin glargine biosimilar product and Lantus® in healthy subjects: Pharmacokinetic parameters of both parent insulin glargine and M1 were used as endpoints
Wang, Yiya, Zhou, Ying, Ding, Juefang, Li, Xianjing, Guo, Fengxue, Zhang, Jianfei, Ding, Li
Published in Frontiers in pharmacology (26.08.2022)
Published in Frontiers in pharmacology (26.08.2022)
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First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1‐receptor partial agonist for the treatment of dementias
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Prins, Samantha, Doef, Thalia F., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Published in British journal of clinical pharmacology (01.07.2021)
Published in British journal of clinical pharmacology (01.07.2021)
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Plasma Exposure to Insulin Glargine and Its Metabolites M1 and M2 After Subcutaneous Injection of Therapeutic and Supratherapeutic Doses of Glargine in Subjects With Type 1 Diabetes
Bolli, Geremia B., Hahn, Annke D., Schmidt, Ronald, Eisenblaetter, Tanja, Dahmen, Raphael, Heise, Tim, Becker, Reinhard H.A.
Published in Diabetes care (01.12.2012)
Published in Diabetes care (01.12.2012)
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M1 large-scale network dynamics support human motor resonance and its plastic reshaping
Guidali, Giacomo, Arrigoni, Eleonora, Bolognini, Nadia, Pisoni, Alberto
Published in NeuroImage (Orlando, Fla.) (01.03.2025)
Published in NeuroImage (Orlando, Fla.) (01.03.2025)
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Relationship between muscarinic M1 receptor binding and cognition in medication-free subjects with psychosis
Bakker, Geor, Vingerhoets, Claudia, Boucherie, Daphne, Caan, Matthan, Bloemen, Oswald, Eersels, Jos, Booij, Jan, van Amelsvoort, Thérèse
Published in NeuroImage clinical (2018)
Published in NeuroImage clinical (2018)
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Glutathione-S-Transferase M1, Obesity, Statins, and Autonomic Effects of Particles: Gene-by-Drug-by-Environment Interaction
Schwartz, Joel, Park, Sung Kyun, O'Neill, Marie S, Vokonas, Pantel S, Sparrow, David, Weiss, Scott, Kelsey, Karl
Published in American journal of respiratory and critical care medicine (15.12.2005)
Published in American journal of respiratory and critical care medicine (15.12.2005)
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The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis
Vingerhoets, Claudia, Bakker, Geor, van Dijk, Jelske, Bloemen, Oswald J.N., Wang, Ya, Chan, Raymond C.K., Booij, Jan, van Amelsvoort, Therese A.M.J.
Published in European neuropsychopharmacology (01.09.2017)
Published in European neuropsychopharmacology (01.09.2017)
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An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
Sindrilaru, Anca, Peters, Thorsten, Wieschalka, Stefan, Baican, Corina, Baican, Adrian, Peter, Henriette, Hainzl, Adelheid, Schatz, Susanne, Qi, Yu, Schlecht, Andrea, Weiss, Johannes M., Wlaschek, Meinhard, Sunderkötter, Cord, Scharffetter-Kochanek, Karin
Published in The Journal of clinical investigation (01.03.2011)
Published in The Journal of clinical investigation (01.03.2011)
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Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, Xian, Cai, Li-Li, Li, Yang, Wang, Ran-Chao, Xu, Yu-Hao, Chen, Ya-Jie, Xie, Yu-Hang, Zhu, Xiao-Lan, Li, Yue-Feng
Published in Journal of nanobiotechnology (09.03.2022)
Published in Journal of nanobiotechnology (09.03.2022)
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Influence of muscarinic M1 receptor antagonism on brain choline levels and functional connectivity in medication-free subjects with psychosis: A placebo controlled, cross-over study
Vingerhoets, Claudia, Bakker, Geor, Schrantee, Anouk, van der Pluijm, Marieke, Bloemen, Oswald J.N., Reneman, Liesbeth, Caan, Matthan, Booij, Jan, van Amelsvoort, Therese A.M.J.
Published in Psychiatry research. Neuroimaging (30.08.2019)
Published in Psychiatry research. Neuroimaging (30.08.2019)
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Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study
Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Doll, Robert Jan, Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Published in Alzheimer's research & therapy (21.04.2021)
Published in Alzheimer's research & therapy (21.04.2021)
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Inhibiting IRE-1 RNase signaling decreases HIV-1 Tat-induced inflammatory M1 state in microglial cells
Roberto Pinto, Aguinaldo, Américo, Monique Ferrary, Terenzi, Hernán, Silveira, Douglas Bardini
Published in Biochimica et biophysica acta. General subjects (01.11.2022)
Published in Biochimica et biophysica acta. General subjects (01.11.2022)
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