Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition
Macdonald, Simon J. F, Belton, David J, Buckley, Doreen M, Spooner, Julie E, Anson, Michael S, Harrison, Lee A, Mills, Keith, Upton, Richard J, Dowle, Michael D, Smith, Robin A, Molloy, Christopher R, Risley, Catherine
Published in Journal of medicinal chemistry (08.10.1998)
Published in Journal of medicinal chemistry (08.10.1998)
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Pharmacological profile of GR117289 in vitro: a novel, potent and specific non‐peptide angiotensin AT1 receptor antagonist
Robertson, M.J., Barnes, J.C., Drew, G.M., Clark, K.L., Marshall, F.H., Michel, A., Middlemiss, D., Ross, B.C., Scopes, D., Dowle, M.D.
Published in British journal of pharmacology (01.12.1992)
Published in British journal of pharmacology (01.12.1992)
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The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase—GW311616A a development candidate
Macdonald, Simon J.F, Dowle, Michael D, Harrison, Lee A, Shah, Pritom, Johnson, Martin R, Inglis, Graham G.A, Clarke, Geoffrey D.E, Smith, Robin A, Humphreys, Davina, Molloy, Christopher R, Amour, Augustin, Dixon, Mary, Murkitt, Graham, Godward, Rosalind E, Padfield, Tony, Skarzynski, Tadeusz, Singh, Onkar M.P, Kumar, K.Abhhilash, Fleetwood, Gill, Hodgson, Simon T, Hardy, George W, Finch, Harry
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
Published in Bioorganic & medicinal chemistry letters (09.04.2001)
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Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams
MACDONALD, Simon J. F, DOWLE, Michael D, MOLLOY, Christopher R, DIXON, Mary, MURKITT, Graham, GODWARD, Rosalind E, SKARZYNSKI, Tadeusz, SINGH, Onkar M. P, KUMAR, K. Abhhilash, HODGSON, Simon T, MCDONALD, Edward, HARDY, George W, HARRISON, Lee A, FINCH, Harry, SPOONER, Julie E, SHAH, Pritom, JOHNSON, Martin R, INGLIS, Graham G. A, CLARKE, Geoffrey D. E, BELTON, David J, SMITH, Robin A
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
Published in Bioorganic & medicinal chemistry letters (22.01.2001)
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Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR
Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Bromobenzofuran-Based Non-peptide Antagonists of Angiotensin II: GR138950, a Potent Antihypertensive Agent with High Oral Bioavailability
Judd, Duncan B, Dowle, Michael D, Middlemiss, David, Scopes, David I. C, Ross, Barry C, Jack, Torquil I, Pass, Martin, Tranquillini, Elvira, Hobson, Julie E
Published in Journal of medicinal chemistry (01.09.1994)
Published in Journal of medicinal chemistry (01.09.1994)
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Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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INTRAMOLECULAR NUCLEOPHILIC-ADDITION TO PHOTOCHEMICALLY GENERATED KETENES AS A VERSATILE ROUTE TO LACTONES AND LACTAMS - SYNTHESIS OF A MOSQUITO PHEROMONE, GONIOTHALAMIN, ARGENTILACTONE, AND THE STREPTOMYCES L-FACTOR
RAHMAN, SS, WAKEFIELD, BJ, ROBERTS, SM, DOWLE, MD
Published in Journal of the Chemical Society. Chemical communications (1989)
Published in Journal of the Chemical Society. Chemical communications (1989)
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Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic Optimization of Inhibitors of Hepatitis C Virus NS3/4A Protease
Andrews, David M, Barnes, Michael C, Dowle, Mike D, Hind, S. Lucy, Johnson, Martin R, Jones, Paul S, Mills, Gail, Patikis, Angela, Pateman, Tony J, Redfern, Tracy J, Robinson, J. Ed, Slater, Martin J, Trivedi, Naimisha
Published in Organic letters (27.11.2003)
Published in Organic letters (27.11.2003)
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Bromobenzofurans : a new class of potent, non-peptide antagonists of angiotensin II
Middlemiss, D, Drew, G.M., Ross, B.C., Robertson, M.J., Scopes, D.I.C., Dowle, M.D., Akers, J, Cardwell, K, Clark, K.L., Coote, S, Eldred, C.D., Hamblett, J, Hilditch, A, Hirst, G.C., Jack, T, Montana, J, Panchal, T.A., Paton, J.M.S., Shah, P, Stuart, G, Travers, A
Published in Bioorganic & medicinal chemistry letters (1991)
Published in Bioorganic & medicinal chemistry letters (1991)
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Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives
Wood, ME, Cane-Honeysett, DJ, Dowle, MD, Coles, SJ, Hursthouse, MB
Published in Organic & biomolecular chemistry (07.09.2003)
Published in Organic & biomolecular chemistry (07.09.2003)
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A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology
Macdonald, Simon J. F, Clarke, Geoffrey D. E, Dowle, Michael D, Harrison, Lee A, Hodgson, Simon T, Inglis, Graham G. A, Johnson, Martin R, Shah, Prit, Upton, Richard J, Walls, Steven B
Published in Journal of organic chemistry (09.07.1999)
Published in Journal of organic chemistry (09.07.1999)
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The design of potent, non-peptidic inhibitors of hepatitis C protease
Andrews, David M., Chaignot, Helene M., Coomber, Barry A., Dowle, Mike D., Lucy Hind, S., Johnson, Martin R., Jones, Paul S., Mills, Gail, Patikis, Angela, Pateman, Tony J., Ed Robinson, J., Slater, Martin J., Trivedi, Naimisha
Published in European journal of medicinal chemistry (01.04.2003)
Published in European journal of medicinal chemistry (01.04.2003)
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Conference Proceeding
Benzofuran based angiotensin II antagonists related to GR117289: enhancement of potency in vitro and oral activity
Middlemiss, D., Watson, S.P., Ross, B.C., Dowle, M.D., Scopes, D.I.C., Montana, J.G., Shah, P., Hirst, G.C., Panchal, T.A., Paton, J.M.S., Pass, M., Hubbard, T., Hamblett, J., Cardwell, K.S., Jack, T.I., Stuart, G., Coote, S., Bradshaw, J., Drew, G.M., Hilditch, A., Clark, K.L., Robertson, M.J., Bayliss, M.K., Donnelly, M., Palmer, E., Manchee, G.R.M.
Published in Bioorganic & medicinal chemistry letters (1993)
Published in Bioorganic & medicinal chemistry letters (1993)
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Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR13950, a potent antihypertensive agent with high oral bioavailability
JUDD, D. B, DOWLE, M. D, STUART, P. G, PATON, J. M. S, HUBBARD, T, HILDITCH, A, DREW, G. M, ROBERTSON, M. J, CLARK, K. L, TRAVERS, A, HUNT, A. E. A, POLLEY, J, MIDDLEMISS, D, EDDERSHAW, P. J, BAYLISS, M. K, MANCHEE, G. R, DONNELLY, M. D, WALKER, D. G, RICHARDS, S. A, SCOPES, D. I. C, ROSS, B. C, JACK, T. I, PASS, M, TRANSUILINI, E, HOBSON, J. E, PANCHAL, T. A
Published in Journal of medicinal chemistry (1994)
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Published in Journal of medicinal chemistry (1994)
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