Resistance to Avapritinib in PDGFRA-Driven GIST Is Caused by Secondary Mutations in the PDGFRA Kinase Domain
Grunewald, Susanne, Klug, Lillian R, Mühlenberg, Thomas, Lategahn, Jonas, Falkenhorst, Johanna, Town, Ajia, Ehrt, Christiane, Wardelmann, Eva, Hartmann, Wolfgang, Schildhaus, Hans-Ulrich, Treckmann, Juergen, Fletcher, Jonathan A, Jung, Sascha, Czodrowski, Paul, Miller, Stephen, Schmidt-Kittler, Oleg, Rauh, Daniel, Heinrich, Michael C, Bauer, Sebastian
Published in Cancer discovery (01.01.2021)
Published in Cancer discovery (01.01.2021)
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Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor
Tomassi, Stefano, Lategahn, Jonas, Engel, Julian, Keul, Marina, Tumbrink, Hannah L, Ketzer, Julia, Mühlenberg, Thomas, Baumann, Matthias, Schultz-Fademrecht, Carsten, Bauer, Sebastian, Rauh, Daniel
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Covalent-Allosteric Kinase Inhibitors
Weisner, Jörn, Gontla, Rajesh, van der Westhuizen, Leandi, Oeck, Sebastian, Ketzer, Julia, Janning, Petra, Richters, André, Mühlenberg, Thomas, Fang, Zhizhou, Taher, Abu, Jendrossek, Verena, Pelly, Stephen C., Bauer, Sebastian, van Otterlo, Willem A. L., Rauh, Daniel
Published in Angewandte Chemie (International ed.) (24.08.2015)
Published in Angewandte Chemie (International ed.) (24.08.2015)
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DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
SIMON, Susanne, GRABELLUS, Florian, SCHULER, Martin, TAGUCHI, Takahiro, FLETCHER, Jonathan A, BAUER, Sebastian, FERRERA, Loretta, GALIETTA, Luis, SCHWINDENHAMMER, Benjamin, MÜHLENBERG, Thomas, TAEGER, Georg, EILERS, Grant, TRECKMANN, Juergen, BREITENBUECHER, Frank
Published in Cancer research (Chicago, Ill.) (15.06.2013)
Published in Cancer research (Chicago, Ill.) (15.06.2013)
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KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors - TORC1/2 Inhibition as Salvage Strategy
Mühlenberg, Thomas, Ketzer, Julia, Heinrich, Michael C, Grunewald, Susanne, Marino-Enriquez, Adrian, Trautmann, Marcel, Hartmann, Wolfgang, Wardelmann, Eva, Treckmann, Jürgen, Worm, Karl, Bertram, Stefanie, Herold, Thomas, Schildhaus, Hans-Ulrich, Glimm, Hanno, Stenzinger, Albrecht, Brors, Benedikt, Horak, Peter, Hohenberger, Peter, Fröhling, Stefan, Fletcher, Jonathan A, Bauer, Sebastian
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors
MÜHLENBERG, Thomas, YIXIANG ZHANG, BAUER, Sebastian, WAGNER, Andrew J, GRABELLUS, Florian, BRADNER, James, TAEGER, Georg, LANG, Hauke, TAGUCHI, Takahiro, SCHULER, Martin, FLETCHER, Jonathan A
Published in Cancer research (Chicago, Ill.) (01.09.2009)
Published in Cancer research (Chicago, Ill.) (01.09.2009)
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Journal Article
Inhibitors to Overcome Secondary Mutations in the Stem Cell Factor Receptor KIT
Kaitsiotou, Helena, Keul, Marina, Hardick, Julia, Mühlenberg, Thomas, Ketzer, Julia, Ehrt, Christiane, Krüll, Jasmin, Medda, Federico, Koch, Oliver, Giordanetto, Fabrizio, Bauer, Sebastian, Rauh, Daniel
Published in Journal of medicinal chemistry (09.11.2017)
Published in Journal of medicinal chemistry (09.11.2017)
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Journal Article
Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor
Mühlenberg, Thomas, Grunewald, Susanne, Treckmann, Jürgen, Podleska, Lars, Schuler, Martin, Fletcher, Jonathan A, Bauer, Sebastian
Published in PloS one (17.03.2015)
Published in PloS one (17.03.2015)
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Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting
Falkenhorst, Johanna, Grunewald, Susanne, Krzeciesa, Dawid, Herold, Thomas, Ketzer, Julia, Christoff, Miriam, Hamacher, Rainer, Kostbade, Karina, Treckmann, Jürgen, Köster, Johannes, Farzaliyev, Farhad, Fletcher, Benjamin Samulon, Dieckmann, Nils, Kaths, Moritz, Mühlenberg, Thomas, Schildhaus, Hans-Ulrich, Bauer, Sebastian
Published in Cancers (01.11.2022)
Published in Cancers (01.11.2022)
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p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors
Henze, Joern, Mühlenberg, Thomas, Simon, Susanne, Grabellus, Florian, Rubin, Brian, Taeger, Georg, Schuler, Martin, Treckmann, Juergen, Debiec-Rychter, Maria, Taguchi, Takahiro, Fletcher, Jonathan A, Bauer, Sebastian
Published in PloS one (25.05.2012)
Published in PloS one (25.05.2012)
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Journal Article
Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth
Edris, Badreddin, Willingham, Stephen B., Weiskopf, Kipp, Volkmer, Anne K., Volkmer, Jens-Peter, Mühlenberg, Thomas, Montgomery, Kelli D., Contreras-Trujillo, Humberto, Czechowicz, Agnieszka, Fletcher, Jonathan A., West, Robert B., Weissman, Irving L., van de Rijn, Matt
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.02.2013)
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Journal Article
Genomic aberrations in cell cycle genes predict progression of KIT -mutant gastrointestinal stromal tumors (GISTs)
Heinrich, Michael C, Patterson, Janice, Beadling, Carol, Wang, Yuexiang, Debiec-Rychter, Maria, Dewaele, Barbara, Corless, Christopher L, Duensing, Anette, Raut, Chandrajit P, Rubin, Brian, Ordog, Tamas, van de Rijn, Matt, Call, Jerry, Mühlenberg, Thomas, Fletcher, Jonathan A, Bauer, Sebastian
Published in Clinical sarcoma research (05.03.2019)
Published in Clinical sarcoma research (05.03.2019)
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Insight into the Inhibition of Drug-Resistant Mutants of the Receptor Tyrosine Kinase EGFR
Engel, Julian, Becker, Christian, Lategahn, Jonas, Keul, Marina, Ketzer, Julia, Mühlenberg, Thomas, Kollipara, Laxmikanth, Schultz-Fademrecht, Carsten, Zahedi, René P., Bauer, Sebastian, Rauh, Daniel
Published in Angewandte Chemie (International ed.) (26.08.2016)
Published in Angewandte Chemie (International ed.) (26.08.2016)
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Reply to Y. Xia et al
Bauer, Sebastian, Fletcher, Jonathan A., Rauh, Daniel, Falkenhorst, Johanna, Mühlenberg, Thomas
Published in Journal of clinical oncology (20.09.2024)
Published in Journal of clinical oncology (20.09.2024)
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Abstract 377: Novel mTOR inhibitor MLN0128 inhibits imatinib-resistant GIST more potently than rapalogues by abrogating AKT and 4EBP1 activation
Mühlenberg, Thomas, Ketzer, Julia, Fletcher, Jonathan A., Bauer, Sebastian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Proapoptotic Activity of Bortezomib in Gastrointestinal Stromal Tumor Cells
BAUER, Sebastian, PARRY, Joshua A, DUENSING, Stefan, DUENSING, Anette, MÜHLENBERG, Thomas, BROWN, Matthew F, SENEVIRATNE, Danushka, CHATTERJEE, Payel, CHIN, Anna, RUBIN, Brian P, KUAN, Shih-Fan, FLETCHER, Jonathan A
Published in Cancer research (Chicago, Ill.) (2010)
Published in Cancer research (Chicago, Ill.) (2010)
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KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor: Emerging Mechanisms of Kinase Inhibitor Escape
Mühlenberg, Thomas, Falkenhorst, Johanna, Schulz, Tom, Fletcher, Benjamin S, Teuber, Alina, Krzeciesa, Dawid, Klooster, Isabella, Lundberg, Meijun, Wilson, Lydia, Lategahn, Jonas, von Mehren, Margaret, Grunewald, Susanne, Tüns, Alicia Isabell, Wardelmann, Eva, Sicklick, Jason K, Brahmi, Mehdi, Serrano, César, Schildhaus, Hans-Ulrich, Sievers, Sonja, Treckmann, Jürgen, Heinrich, Michael C, Raut, Chandrajit P, Ou, Wen-Bin, Marino-Enriquez, Adrian, George, Suzanne, Rauh, Daniel, Fletcher, Jonathan A, Bauer, Sebastian
Published in Journal of clinical oncology (20.04.2024)
Published in Journal of clinical oncology (20.04.2024)
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Abstract 3005: Comprehensive profile of platelet derived growth factor receptor alpha (PDGFRA) mutations in gastrointestinal stromal tumors
Khosroyani, Homma, Klug, Lillian R., Town, Ajia, Lategahn, Jonas, Falkenhorst, Johanna, Grunewald, Susanne, Mühlenberg, Thomas, Ehrt, Christiane, Wardelmann, Eve, Hartmann, Wolfgang, Schildhaus, Hans-Ulrich, Jung, Sascha, Czodrowski, Paul, Agaimy, Abbas, Rutkowski, Piotr, Rauh, Daniel, Bauer, Sebastian, Heinrich, Michael C.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S
Lategahn, Jonas, Keul, Marina, Klövekorn, Philip, Tumbrink, Hannah L, Niggenaber, Janina, Müller, Matthias P, Hodson, Luke, Flaßhoff, Maren, Hardick, Julia, Grabe, Tobias, Engel, Julian, Schultz-Fademrecht, Carsten, Baumann, Matthias, Ketzer, Julia, Mühlenberg, Thomas, Hiller, Wolf, Günther, Georgia, Unger, Anke, Müller, Heiko, Heimsoeth, Alena, Golz, Christopher, Blank-Landeshammer, Bernhard, Kollipara, Laxmikanth, Zahedi, René P, Strohmann, Carsten, Hengstler, Jan G, van Otterlo, Willem A. L, Bauer, Sebastian, Rauh, Daniel
Published in Chemical science (Cambridge) (14.12.2019)
Published in Chemical science (Cambridge) (14.12.2019)
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