Structural and chemical trapping of flavin‐oxide intermediates reveals substrate‐directed reaction multiplicity
Lin, Kuan‐Hung, Lyu, Syue‐Yi, Yeh, Hsien‐Wei, Li, Yi‐Shan, Hsu, Ning‐Shian, Huang, Chun‐Man, Wang, Yung‐Lin, Shih, Hao‐Wei, Wang, Zhe‐Chong, Wu, Chang‐Jer, Li, Tsung‐Lin
Published in Protein science (01.07.2020)
Published in Protein science (01.07.2020)
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Journal Article
Biosynthesis of Streptolidine Involved Two Unexpected Intermediates Produced by a Dihydroxylase and a Cyclase through Unusual Mechanisms
Chang, Chin-Yuan, Lyu, Syue-Yi, Liu, Yu-Chen, Hsu, Ning-Shian, Wu, Chih-Chung, Tang, Cheng-Fong, Lin, Kuan-Hung, Ho, Jin-Yuan, Wu, Chang-Jer, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Angewandte Chemie International Edition (10.02.2014)
Published in Angewandte Chemie International Edition (10.02.2014)
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Journal Article
The Mesomeric Effect of Thiazolium on non‐Kekulé Diradicals in Pichia stipitis Transketolase
Hsu, Ning‐Shian, Wang, Yung‐Lin, Lin, Kuan‐Hung, Chang, Chi‐Fon, Lyu, Syue‐Yi, Hsu, Li‐Jen, Liu, Yu‐Chen, Chang, Chin‐Yuan, Wu, Chang‐Jer, Li, Tsung‐Lin
Published in Angewandte Chemie International Edition (12.02.2018)
Published in Angewandte Chemie International Edition (12.02.2018)
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Journal Article
Evidence of Diradicals Involved in the Yeast Transketolase Catalyzed Keto‐Transferring Reactions
Hsu, Ning‐Shian, Wang, Yung‐Lin, Lin, Kuan‐Hung, Chang, Chi‐Fon, Ke, Shyue‐Chu, Lyu, Syue‐Yi, Hsu, Li‐Jen, Li, Yi‐Shan, Chen, Sheng‐Chia, Wang, Kuei‐Chen, Li, Tsung‐Lin
Published in Chembiochem : a European journal of chemical biology (16.11.2018)
Published in Chembiochem : a European journal of chemical biology (16.11.2018)
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Journal Article
Biochemical and structural explorations of α‐hydroxyacid oxidases reveal a four‐electron oxidative decarboxylation reaction
Yeh, Hsien-Wei, Lin, Kuan-Hung, Lyu, Syue-Yi, Li, Yi-Shan, Huang, Chun-Man, Wang, Yung-Lin, Shih, Hao-Wei, Hsu, Ning-Shian, Wu, Chang-Jer, Li, Tsung-Lin
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2019)
Published in Acta crystallographica. Section D, Biological crystallography. (01.08.2019)
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Journal Article
The flavin mononucleotide cofactor in α‐hydroxyacid oxidases exerts its electrophilic/nucleophilic duality in control of the substrate‐oxidation level
Lyu, Syue-Yi, Lin, Kuan-Hung, Yeh, Hsien-Wei, Li, Yi-Shan, Huang, Chun-Man, Wang, Yung-Lin, Shih, Hao-Wei, Hsu, Ning-Shian, Wu, Chang-Jer, Li, Tsung-Lin
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2019)
Published in Acta crystallographica. Section D, Biological crystallography. (01.10.2019)
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Journal Article
Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds
Liu, Yu-Chen, Li, Yi-Shan, Lyu, Syue-Yi, Hsu, Li-Jen, Chen, Yu-Hou, Huang, Yu-Ting, Chan, Hsiu-Chien, Huang, Chuen-Jiuan, Chen, Gan-Hong, Chou, Chia-Cheng, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Nature chemical biology (01.05.2011)
Published in Nature chemical biology (01.05.2011)
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Journal Article
β-Hydroxylation of α-amino-β-hydroxylbutanoyl-glycyluridine catalyzed by a nonheme hydroxylase ensures the maturation of caprazamycin
Zadeh, Saeid Malek, Chen, Mei-Hua, Wang, Zhe-Chong, Astani, Elahe K., Lo, I-Wen, Lin, Kuan-Hung, Hsu, Ning-Shian, Adhikari, Kamal, Lyu, Syue-Yi, Tsai, Hsin-Ying, Terasawa, Yuma, Yabe, Miyuki, Yamamoto, Kazuki, Ichikawa, Satoshi, Li, Tsung-Lin
Published in Communications chemistry (28.07.2022)
Published in Communications chemistry (28.07.2022)
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Journal Article
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes
Wang, Kuei-Chen, Lyu, Syue-Yi, Liu, Yu-Chen, Chang, Chin-Yuan, Wu, Chang-Jer, Li, Tsung-Lin
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2014)
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Journal Article
Chain Elongation and Cyclization in Type III PKS DpgA
Wu, Hai-Chen, Li, Yi-San, Liu, Yu-Chen, Lyu, Syue-Yi, Wu, Chang-Jer, Li, Tsung-Lin
Published in Chembiochem : a European journal of chemical biology (16.04.2012)
Published in Chembiochem : a European journal of chemical biology (16.04.2012)
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Journal Article
In vitro Characterization of Enzymes Involved in the Synthesis of Nonproteinogenic Residue (2S,3S)-β-Methylphenylalanine in Glycopeptide Antibiotic Mannopeptimycin
Huang, Yu-Ting, Lyu, Syue-Yi, Chuang, Pei-Hsuan, Hsu, Ning-Shian, Li, Yi-Shan, Chan, Hsiu-Chien, Huang, Chuen-Jiuan, Liu, Yu-Chen, Wu, Chang-Jer, Yang, Wen-Bin, Li, Tsung-Lin
Published in Chembiochem : a European journal of chemical biology (12.10.2009)
Published in Chembiochem : a European journal of chemical biology (12.10.2009)
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Journal Article
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Zou, Xiao-Wei, Liu, Yu-Chen, Hsu, Ning-Shian, Huang, Chuen-Jiuan, Lyu, Syue-Yi, Chan, Hsiu-Chien, Chang, Chin-Yuan, Yeh, Hsien-Wei, Lin, Kuan-Hung, Wu, Chang-Jer, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.06.2014)
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Journal Article
Biosynthesis of Streptolidine Involved Two Unexpected Intermediates Produced by a Dihydroxylase and a Cyclase through Unusual Mechanisms
Chang, Chin-Yuan, Lyu, Syue-Yi, Liu, Yu-Chen, Hsu, Ning-Shian, Wu, Chih-Chung, Tang, Cheng-Fong, Lin, Kuan-Hung, Ho, Jin-Yuan, Wu, Chang-Jer, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Angewandte Chemie (10.02.2014)
Published in Angewandte Chemie (10.02.2014)
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Journal Article
Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification
Li, Tsung-Lin, Liu, Yu-Chen, Lyu, Syue-Yi
Published in Current opinion in chemical biology (01.04.2012)
Published in Current opinion in chemical biology (01.04.2012)
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Journal Article
Multiple Complexes of Long Aliphatic N‑Acyltransferases Lead to Synthesis of 2,6-Diacylated/2-Acyl-Substituted Glycopeptide Antibiotics, Effectively Killing Vancomycin-Resistant Enterococcus
Lyu, Syue-Yi, Liu, Yu-Chen, Chang, Chin-Yuan, Huang, Chuen-Jiuan, Chiu, Ya-Huang, Huang, Chun-Man, Hsu, Ning-Shian, Lin, Kuan-Hung, Wu, Chang-Jer, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Journal of the American Chemical Society (06.08.2014)
Published in Journal of the American Chemical Society (06.08.2014)
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Journal Article
Teicoplanin Reprogrammed with the N‑Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens
Huang, Chun-Man, Lyu, Syue-Yi, Lin, Kuan-Hung, Chen, Chun-Liang, Chen, Mei-Hua, Shih, Hao-Wei, Hsu, Ning-Shian, Lo, I-Wen, Wang, Yung-Lin, Li, Yi-Shan, Wu, Chang-Jer, Li, Tsung-Lin
Published in ACS infectious diseases (08.03.2019)
Published in ACS infectious diseases (08.03.2019)
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Journal Article
The Mesomeric Effect of Thiazolium on non‐Kekulé Diradicals in Pichia stipitis Transketolase
Hsu, Ning‐Shian, Wang, Yung‐Lin, Lin, Kuan‐Hung, Chang, Chi‐Fon, Lyu, Syue‐Yi, Hsu, Li‐Jen, Liu, Yu‐Chen, Chang, Chin‐Yuan, Wu, Chang‐Jer, Li, Tsung‐Lin
Published in Angewandte Chemie (12.02.2018)
Published in Angewandte Chemie (12.02.2018)
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Journal Article
Regioselective deacetylation based on teicoplanin-complexed Orf2 crystal structures
Chan, Hsiu-Chien, Huang, Yu-Ting, Lyu, Syue-Yi, Huang, Chuen-Jiuan, Li, Yi-Shan, Liu, Yu-Chen, Chou, Chia-Cheng, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Molecular bioSystems (01.04.2011)
Published in Molecular bioSystems (01.04.2011)
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Journal Article
A Unique Flavin Mononucleotide-Linked Primary Alcohol Oxidase for Glycopeptide A40926 Maturation
Li, Yi-Shan, Ho, Jin-Yuan, Huang, Chia-Chi, Lyu, Syue-Yi, Lee, Chun-Yen, Huang, Yu-Ting, Wu, Chang-Jer, Chan, Hsiu-Chien, Huang, Chuan-Jiuan, Hsu, Ning-Shian, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Journal of the American Chemical Society (07.11.2007)
Published in Journal of the American Chemical Society (07.11.2007)
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Journal Article
Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds
Liu, Yu-Chen, Li, Yi-Shan, Lyu, Syue-Yi, Hsu, Li-Jen, Chen, Yu-Hou, Huang, Yu-Ting, Chan, Hsiu-Chien, Huang, Chuen-Jiuan, Chen, Gan-Hong, Chou, Chia-Cheng, Tsai, Ming-Daw, Li, Tsung-Lin
Published in Nature chemical biology (01.05.2015)
Published in Nature chemical biology (01.05.2015)
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