Genetic and transcriptional evolution alters cancer cell line drug response
Ben-David, Uri, Siranosian, Benjamin, Ha, Gavin, Tang, Helen, Oren, Yaara, Hinohara, Kunihiko, Strathdee, Craig A., Dempster, Joshua, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Kugener, Guillaume, Cimini, Beth, Tsvetkov, Peter, Maruvka, Yosef E., O’Rourke, Ryan, Garrity, Anthony, Tubelli, Andrew A., Bandopadhayay, Pratiti, Tsherniak, Aviad, Vazquez, Francisca, Wong, Bang, Birger, Chet, Ghandi, Mahmoud, Thorner, Aaron R., Bittker, Joshua A., Meyerson, Matthew, Getz, Gad, Beroukhim, Rameen, Golub, Todd R.
Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention
Khan, Tashbib, Kryza, Thomas, Lyons, Nicholas J, He, Yaowu, Hooper, John D
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Drug and disease signature integration identifies synergistic combinations in glioblastoma
Stathias, Vasileios, Jermakowicz, Anna M., Maloof, Marie E., Forlin, Michele, Walters, Winston, Suter, Robert K., Durante, Michael A., Williams, Sion L., Harbour, J. William, Volmar, Claude-Henry, Lyons, Nicholas J., Wahlestedt, Claes, Graham, Regina M., Ivan, Michael E., Komotar, Ricardo J., Sarkaria, Jann N., Subramanian, Aravind, Golub, Todd R., Schürer, Stephan C., Ayad, Nagi G.
Published in Nature communications (14.12.2018)
Published in Nature communications (14.12.2018)
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Whole‐blood dysregulation of actin‐cytoskeleton pathway in adult spinal muscular atrophy patients
Siranosian, Jennifer J., Nery, Flavia C., Alves, Christiano R. R., Siranosian, Benjamin A., Lyons, Nicholas J., Eichelberger, Eric J., Garner, Reid, Da Silva Duarte Lepez, Salomé, Johnstone, Alec J., Subramanian, Aravind, Swoboda, Kathryn J.
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Published in Annals of clinical and translational neurology (01.07.2020)
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Noncanonical open reading frames encode functional proteins essential for cancer cell survival
Prensner, John R., Enache, Oana M., Luria, Victor, Krug, Karsten, Clauser, Karl R., Dempster, Joshua M., Karger, Amir, Wang, Li, Stumbraite, Karolina, Wang, Vickie M., Botta, Ginevra, Lyons, Nicholas J., Goodale, Amy, Kalani, Zohra, Fritchman, Briana, Brown, Adam, Alan, Douglas, Green, Thomas, Yang, Xiaoping, Jaffe, Jacob D., Roth, Jennifer A., Piccioni, Federica, Kirschner, Marc W., Ji, Zhe, Root, David E., Golub, Todd R.
Published in Nature biotechnology (01.06.2021)
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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling
Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, McFarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'Hearn, Patrick J, Stefan, Eric, Doench, John G, Harrington, Caitlin N, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R
Published in Nature cancer (01.02.2020)
Published in Nature cancer (01.02.2020)
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Reactive Oxygen Species as Mediators of Disease Progression and Therapeutic Response in Colorectal Cancer
Lyons, Nicholas J, Giri, Rabina, Begun, Jakob, Clark, David, Proud, David, He, Yaowu, Hooper, John D, Kryza, Thomas
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Patient and pathological predictors of management strategy for malignant polyps following polypectomy: a systematic review and meta-analysis
Zammit, Andrew P., Lyons, Nicholas J., Chatfield, Mark D., Hooper, John D., Brown, Ian, Clark, David A., Riddell, Andrew D.
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Published in International journal of colorectal disease (01.05.2022)
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Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer
He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L, Goh, Justin B, Lyons, Nicholas J, Pearce, Lesley A, Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C, Perrin, Lewis C, Williams, Charlotte C, Puttick, Simon, Adams, Timothy E, Munro, Trent P, Hooper, John D, Chetty, Naven
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CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
Khan, Tashbib, Lyons, Nicholas J, Gough, Madeline, Kwah, Kayden K X, Cuda, Tahleesa J, Snell, Cameron E, Tse, Brian W, Sokolowski, Kamil A, Pearce, Lesley A, Adams, Timothy E, Rose, Stephen E, Puttick, Simon, Pajic, Marina, Adams, Mark N, He, Yaowu, Hooper, John D, Kryza, Thomas
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Published in Theranostics (01.01.2022)
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A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations
Litichevskiy, Lev, Peckner, Ryan, Abelin, Jennifer G., Asiedu, Jacob K., Creech, Amanda L., Davis, John F., Davison, Desiree, Dunning, Caitlin M., Egertson, Jarrett D., Egri, Shawn, Gould, Joshua, Ko, Tak, Johnson, Sarah A., Lahr, David L., Lam, Daniel, Liu, Zihan, Lyons, Nicholas J., Lu, Xiaodong, MacLean, Brendan X., Mungenast, Alison E., Officer, Adam, Natoli, Ted E., Papanastasiou, Malvina, Patel, Jinal, Sharma, Vagisha, Toder, Courtney, Tubelli, Andrew A., Young, Jennie Z., Carr, Steven A., Golub, Todd R., Subramanian, Aravind, MacCoss, Michael J., Tsai, Li-Huei, Jaffe, Jacob D.
Published in Cell systems (25.04.2018)
Published in Cell systems (25.04.2018)
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PET Imaging Quantifying 68Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer
Cuda, Tahleesa J, Riddell, Andrew D, Liu, Cheng, Whitehall, Vicki L, Borowsky, Jennifer, Wyld, David K, Burge, Matthew E, Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas JR, Rose, Stephen E, Clark, David A, Stevenson, Andrew RL, Hooper, John D, Puttick, Simon, Thomas, Paul A
Published in The Journal of nuclear medicine (1978) (01.11.2020)
Published in The Journal of nuclear medicine (1978) (01.11.2020)
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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Subramanian, Aravind, Narayan, Rajiv, Corsello, Steven M., Peck, David D., Natoli, Ted E., Lu, Xiaodong, Gould, Joshua, Davis, John F., Tubelli, Andrew A., Asiedu, Jacob K., Lahr, David L., Hirschman, Jodi E., Liu, Zihan, Donahue, Melanie, Julian, Bina, Khan, Mariya, Wadden, David, Smith, Ian C., Lam, Daniel, Liberzon, Arthur, Toder, Courtney, Bagul, Mukta, Orzechowski, Marek, Enache, Oana M., Piccioni, Federica, Johnson, Sarah A., Lyons, Nicholas J., Berger, Alice H., Shamji, Alykhan F., Brooks, Angela N., Vrcic, Anita, Flynn, Corey, Rosains, Jacqueline, Takeda, David Y., Hu, Roger, Davison, Desiree, Lamb, Justin, Ardlie, Kristin, Hogstrom, Larson, Greenside, Peyton, Gray, Nathanael S., Clemons, Paul A., Silver, Serena, Wu, Xiaoyun, Zhao, Wen-Ning, Read-Button, Willis, Wu, Xiaohua, Haggarty, Stephen J., Ronco, Lucienne V., Boehm, Jesse S., Schreiber, Stuart L., Doench, John G., Bittker, Joshua A., Root, David E., Wong, Bang, Golub, Todd R.
Published in Cell (30.11.2017)
Published in Cell (30.11.2017)
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Non-canonical open reading frames encode functional proteins essential for cancer cell survival
Prensner, John R., Enache, Oana M., Luria, Victor, Krug, Karsten, Clauser, Karl R., Dempster, Joshua M., Karger, Amir, Wang, Li, Stumbraite, Karolina, Wang, Vickie M., Botta, Ginevra, Lyons, Nicholas J., Goodale, Amy, Kalani, Zohra, Fritchman, Briana, Brown, Adam, Alan, Douglas, Green, Thomas, Yang, Xiaoping, Jaffe, Jacob D., Roth, Jennifer A., Piccioni, Federica, Kirschner, Marc W., Ji, Zhe, Root, David E., Golub, Todd R.
Published in Nature biotechnology (28.01.2021)
Published in Nature biotechnology (28.01.2021)
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Non-oncology drugs are a source of previously unappreciated anti-cancer activity
Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Jordan, Rossen, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, Mcfarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'hearn, Patrick J, Stefan, Eric, Doench, John G, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R
Published in bioRxiv (09.08.2019)
Published in bioRxiv (09.08.2019)
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PET Imaging Quantifying 68 Ga-PSMA-11 Uptake in Metastatic Colorectal Cancer
Cuda, Tahleesa J, Riddell, Andrew D, Liu, Cheng, Whitehall, Vicki L, Borowsky, Jennifer, Wyld, David K, Burge, Matthew E, Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas J R, Rose, Stephen E, Clark, David A, Stevenson, Andrew R L, Hooper, John D, Puttick, Simon, Thomas, Paul A
Published in Journal of Nuclear Medicine (01.11.2020)
Published in Journal of Nuclear Medicine (01.11.2020)
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Abstract 214: Genetic and transcriptional instability alters cell line drug response
Ben-David, Uri, Siranosian, Ben, Ha, Gavin, Tang, Helen, Lyons, Nicholas J., Burns, Robert, Nag, Anwesha, Cimini, Beth, Tsvetkov, Peter, Tubelli, Andrew A., Wong, Bang, Thorner, Aaron R., Bittker, Joshua, Meyerson, Matthew, Beroukhim, Rameen, Golub, Todd R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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