EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation
Huston, Elaine, Lynch, Martin J, Mohamed, Ahmed, Collins, Daniel M, Hill, Elaine V, MacLeod, Ruth, Krause, Eberhard, Baillie, George S, Houslay, Miles D
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (02.09.2008)
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Journal Article
Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability
Rampersad, Sarah N., Ovens, Jeffrey D., Huston, Elaine, Umana, M. Bibiana, Wilson, Lindsay S., Netherton, Stuart J., Lynch, Martin J., Baillie, George S., Houslay, Miles D., Maurice, Donald H.
Published in The Journal of biological chemistry (29.10.2010)
Published in The Journal of biological chemistry (29.10.2010)
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Journal Article
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5
Bolger, Graeme B, Baillie, George S, Li, Xiang, Lynch, Martin J, Herzyk, Pawel, Mohamed, Ahmed, Mitchell, Lisa High, McCahill, Angela, Hundsrucker, Christian, Klussmann, Enno, Adams, David R, Houslay, Miles D
Published in Biochemical journal (15.08.2006)
Published in Biochemical journal (15.08.2006)
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Journal Article
Tyrosine 302 in RACK1 Is Essential for Insulin-like Growth Factor-I-mediated Competitive Binding of PP2A and β1 Integrin and for Tumor Cell Proliferation and Migration
Kiely, Patrick A., Baillie, George S., Lynch, Martin J., Houslay, Miles D., O'Connor, Rosemary
Published in The Journal of biological chemistry (22.08.2008)
Published in The Journal of biological chemistry (22.08.2008)
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Journal Article
The regulation of biofilm development by quorum sensing in Aeromonas hydrophila
Lynch, Martin J., Swift, Simon, Kirke, David F., Keevil, C. William, Dodd, Christine E. R., Williams, Paul
Published in Environmental microbiology (01.01.2002)
Published in Environmental microbiology (01.01.2002)
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Journal Article
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway
Sachs, Benjamin D, Baillie, George S, McCall, Julianne R, Passino, Melissa A, Schachtrup, Christian, Wallace, Derek A, Dunlop, Allan J, MacKenzie, Kirsty F, Klussmann, Enno, Lynch, Martin J, Sikorski, Shoana L, Nuriel, Tal, Tsigelny, Igor, Zhang, Jin, Houslay, Miles D, Chao, Moses V, Akassoglou, Katerina
Published in The Journal of cell biology (18.06.2007)
Published in The Journal of cell biology (18.06.2007)
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Journal Article
Dynamic Regulation, Desensitization, and Cross-talk in Discrete Subcellular Microdomains during β2-Adrenoceptor and Prostanoid Receptor cAMP Signaling
Willoughby, Debbie, Baillie, George S., Lynch, Martin J., Ciruela, Antonio, Houslay, Miles D., Cooper, Dermot M.F.
Published in The Journal of biological chemistry (23.11.2007)
Published in The Journal of biological chemistry (23.11.2007)
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Journal Article
In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)
McCahill, Angela, Campbell, Lachlan, McSorley, Theresa, Sood, Arvind, Lynch, Martin J., Li, Xiang, Yan, Chen, Baillie, George S., Houslay, Miles D.
Published in Cellular signalling (01.11.2008)
Published in Cellular signalling (01.11.2008)
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Journal Article
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
Terrin, Anna, Di Benedetto, Giulietta, Pertegato, Vanessa, Cheung, York-Fong, Baillie, George, Lynch, Martin J, Elvassore, Nicola, Prinz, Anke, Herberg, Friedrich W, Houslay, Miles D, Zaccolo, Manuela
Published in The Journal of cell biology (06.11.2006)
Published in The Journal of cell biology (06.11.2006)
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Journal Article
PGE₁ stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
Terrin, Anna, Di Benedetto, Giulietta, Pertegato, Vanessa, Cheung, York-Fong, Baillie, George, Lynch, Martin J, Elvassore, Nicola, Prinz, Anke, Herberg, Friedrich W, Houslay, Miles D, Zaccolo, Manuela
Published in The Journal of cell biology (06.11.2006)
Published in The Journal of cell biology (06.11.2006)
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Journal Article
MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization
Meng, Dong, Lynch, Martin J., Huston, Elaine, Beyermann, Michael, Eichhorst, Jenny, Adams, David R., Klussmann, Enno, Houslay, Miles D., Baillie, George S.
Published in The Journal of biological chemistry (24.04.2009)
Published in The Journal of biological chemistry (24.04.2009)
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Journal Article
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
McCahill, Angela, McSorley, Theresa, Huston, Elaine, Hill, Elaine V., Lynch, Martin J., Gall, Irene, Keryer, Guy, Lygren, Birgitte, Tasken, Kjetil, van Heeke, Gino, Houslay, Miles D.
Published in Cellular signalling (01.09.2005)
Published in Cellular signalling (01.09.2005)
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Journal Article
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes
Li, Xiang, Huston, Elaine, Lynch, Martin J., Houslay, Miles D., Baillie, George S.
Published in Biochemical journal (01.03.2006)
Published in Biochemical journal (01.03.2006)
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Journal Article
Intracellular Targeting of Phosphodiesterase‐4 Underpins Compartmentalized cAMP Signaling
Lynch, Martin J., Hill, Elaine V., Houslay, Miles D.
Published in Current Topics in Developmental Biology (2006)
Published in Current Topics in Developmental Biology (2006)
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Book Chapter
Journal Article
Quorum sensing-dependent regulation and blockade of exoprotease production in Aeromonas hydrophila
Swift, S, Lynch, M.J, Fish, L, Kirke, D.F, Tomas, J.M, Stewart, G.S.A.B, Williams, P
Published in Infection and Immunity (01.10.1999)
Published in Infection and Immunity (01.10.1999)
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Journal Article
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice
Grønning, Line M., Baillie, George S., Cederberg, Anna, Lynch, Martin J., Houslay, Miles D., Enerbäck, Sven, Taskén, Kjetil
Published in FEBS letters (24.07.2006)
Published in FEBS letters (24.07.2006)
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Journal Article
Electrospray ionization mass spectrometry of semduramicin and other polyether ionophores
Schneider, Richard P, Lynch, Martin J, Ericson, Jon F, Fouda, Hassan G
Published in Analytical chemistry (Washington) (01.09.1991)
Published in Analytical chemistry (Washington) (01.09.1991)
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Journal Article
Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene
Johnston, Lee Ann, Erdogan, Suat, Cheung, York Fong, Sullivan, Michael, Barber, Rachael, Lynch, Martin J, Baillie, George S, Van Heeke, Gino, Adams, David R, Huston, Elaine, Houslay, Miles D
Published in Biochemical journal (01.06.2004)
Published in Biochemical journal (01.06.2004)
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Journal Article
RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
Lynch, Martin J., Baillie, George S., Mohamed, Ahmed, Li, Xiang, Maisonneuve, Charlotte, Klussmann, Enno, van Heeke, Gino, Houslay, Miles D.
Published in The Journal of biological chemistry (30.09.2005)
Published in The Journal of biological chemistry (30.09.2005)
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Journal Article