Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites
Coetzee, Nanika, von Grüning, Hilde, Opperman, Daniel, van der Watt, Mariette, Reader, Janette, Birkholtz, Lyn-Marié
Published in Scientific reports (11.02.2020)
Published in Scientific reports (11.02.2020)
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Journal Article
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation
van Biljon, Riëtte, van Wyk, Roelof, Painter, Heather J, Orchard, Lindsey, Reader, Janette, Niemand, Jandeli, Llinás, Manuel, Birkholtz, Lyn-Marie
Published in BMC genomics (03.12.2019)
Published in BMC genomics (03.12.2019)
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Journal Article
A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development
von Grüning, Hilde, Coradin, Mariel, Mendoza, Mariel R., Reader, Janette, Sidoli, Simone, Garcia, Benjamin A., Birkholtz, Lyn-Marié
Published in Molecular & cellular proteomics (01.03.2022)
Published in Molecular & cellular proteomics (01.03.2022)
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Journal Article
Parasite genetic diversity reflects continued residual malaria transmission in Vhembe District, a hotspot in the Limpopo Province of South Africa
Gwarinda, Hazel B, Tessema, Sofonias K, Raman, Jaishree, Greenhouse, Bryan, Birkholtz, Lyn-Marié
Published in Malaria journal (16.02.2021)
Published in Malaria journal (16.02.2021)
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Journal Article
Genetic complexity alters drug susceptibility of asexual and gametocyte stages of Plasmodium falciparum to antimalarial candidates
Greyling, Nicola, van der Watt, Mariëtte, Gwarinda, Hazel, van Heerden, Ashleigh, Greenhouse, Bryan, Leroy, Didier, Niemand, Jandeli, Birkholtz, Lyn-Marié
Published in Antimicrobial agents and chemotherapy (06.03.2024)
Published in Antimicrobial agents and chemotherapy (06.03.2024)
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Journal Article
Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors
Olivier, Tania, Loots, Leigh, Kok, Michélle, Villiers, Marianne, Reader, Janette, Birkholtz, Lyn‐Marié, Arnott, Gareth E., Villiers, Katherine A.
Published in ChemMedChem (18.05.2022)
Published in ChemMedChem (18.05.2022)
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Journal Article
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity
Mutombo Mianda, Sephora, Moyo, Phanankosi, Maboane, Suzan, Birkholtz, Lyn-Marié, Maharaj, Vinesh J.
Published in Natural product research (17.10.2024)
Published in Natural product research (17.10.2024)
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Journal Article
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites
Mianda, Sephora Mutombo, Invernizzi, Luke, van der Watt, Mariëtte E., Reader, Janette, Moyo, Phanankosi, Birkholtz, Lyn-Marié, Maharaj, Vinesh J.
Published in Journal of ethnopharmacology (28.10.2022)
Published in Journal of ethnopharmacology (28.10.2022)
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Journal Article
New Transmission‐Selective Antimalarial Agents through Hit‐to‐Lead Optimization of 2‐([1,1′‐Biphenyl]‐4‐carboxamido)benzoic Acid Derivatives
Reader, Janette, Opperman, Daniel F. L., Watt, Mariëtte E., Theron, Anjo, Leshabane, Meta, Rocha, Shanté, Turner, Jonathan, Garrabrant, Kathleen, Piña, Ivett, Mills, Catherine, Woster, Patrick M., Birkholtz, Lyn‐Marié
Published in Chembiochem : a European journal of chemical biology (04.11.2022)
Published in Chembiochem : a European journal of chemical biology (04.11.2022)
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Journal Article
Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites
Coetzee, Nanika, Sidoli, Simone, van Biljon, Riëtte, Painter, Heather, Llinás, Manuel, Garcia, Benjamin A., Birkholtz, Lyn-Marie
Published in Scientific reports (04.04.2017)
Published in Scientific reports (04.04.2017)
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Journal Article
Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites
van Biljon, Riëtte, Niemand, Jandeli, van Wyk, Roelof, Clark, Katherine, Verlinden, Bianca, Abrie, Clarissa, von Grüning, Hilde, Smidt, Werner, Smit, Annél, Reader, Janette, Painter, Heather, Llinás, Manuel, Doerig, Christian, Birkholtz, Lyn-Marié
Published in Scientific reports (08.11.2018)
Published in Scientific reports (08.11.2018)
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Journal Article
MALBoost: a web-based application for gene regulatory network analysis in Plasmodium falciparum
van Wyk, Roelof, van Biljon, Riëtte, Birkholtz, Lyn-Marie
Published in Malaria journal (14.07.2021)
Published in Malaria journal (14.07.2021)
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Journal Article
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy
Dziwornu, Godwin Akpeko, Seanego, Donald, Fienberg, Stephen, Clements, Monica, Ferreira, Jasmin, Sypu, Venkata S., Samanta, Sauvik, Bhana, Ashlyn D., Korkor, Constance M., Garnie, Larnelle F., Teixeira, Nicole, Wicht, Kathryn J., Taylor, Dale, Olckers, Ronald, Njoroge, Mathew, Gibhard, Liezl, Salomane, Nicolaas, Wittlin, Sergio, Mahato, Rohit, Chakraborty, Arnish, Sevilleno, Nicole, Coyle, Rachael, Lee, Marcus C. S., Godoy, Luiz C., Pasaje, Charisse Flerida, Niles, Jacquin C., Reader, Janette, van der Watt, Mariette, Birkholtz, Lyn-Marié, Bolscher, Judith M., de Bruijni, Marloes H. C., Coulson, Lauren B., Basarab, Gregory S., Ghorpade, Sandeep R., Chibale, Kelly
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
High levels of imported asymptomatic malaria but limited local transmission in KwaZulu-Natal, a South African malaria-endemic province nearing malaria elimination
Raman, Jaishree, Gast, Laura, Balawanth, Ryleen, Tessema, Sofonias, Brooke, Basil, Maharaj, Rajendra, Munhenga, Givemore, Tshikae, Power, Lakan, Vishan, Mwamba, Tshiama, Makowa, Hazel, Sangweni, Lindi, Mkhabela, Moses, Zondo, Nompumelelo, Mohulatsi, Ernest, Nyawo, Zuziwe, Ngxongo, Sifiso, Msimang, Sipho, Dagata, Nicole, Greenhouse, Bryan, Birkholtz, Lyn-Marie, Shirreff, George, Graffy, Rebecca, Qwabe, Bheki, Moonasar, Devanand
Published in Malaria journal (15.04.2020)
Published in Malaria journal (15.04.2020)
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Journal Article