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Hayden, Mary K., Bonten, Marc J. M., Blom, Donald W., Lyle, Elizabeth A., van de Vijver, David A. M. C., Weinstein, Robert A.
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Published in Clinical infectious diseases (01.06.2006)
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Alterations in peripheral blood lymphocyte cytokine expression in obesity
O'Rourke, R. W., Kay, T., Lyle, E. A., Traxler, S. A., Deveney, C. W., Jobe, B. A., Roberts, C. T., Marks, D., Rosenbaum, J. T.
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Published in Clinical and experimental immunology (01.10.2006)
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Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position
Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.08.1998)
Published in Journal of medicinal chemistry (13.08.1998)
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Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support
Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P
Published in Journal of medicinal chemistry (29.01.1998)
Published in Journal of medicinal chemistry (29.01.1998)
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Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid d-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy
Tucker, Thomas J, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Lucas, Bobby J, Baskin, Elizabeth P, Woltmann, Richard, Lynch, Joseph J, Lyle, Elizabeth A, Appleby, Sandra D, Chen, I-Wu, Dancheck, Kimberley B, Vacca, Joseph P
Published in Journal of medicinal chemistry (23.05.1997)
Published in Journal of medicinal chemistry (23.05.1997)
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L-374,087, an efficacious, orally bioavailable, pyridinone acetamide thrombin inhibitor
Sanderson, Philip E.J., Cutrona, Kellie J., Dorsey, Bruce D., Dyer, Dona L., McDonough, Colleen M., Naylor-Olsen, Adel M., Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J., Gardell, Stephen J., Krueger, Julie A., Lewis, S.Dale, Lin, Jiunn H., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Stranieri, Maria T., Vastag, Kari, Shafer, Jules A., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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Inhibition of thrombin by peptides containing Lysyl-alpha-keto carbonyl derivatives
Lewis, S D, Ng, A S, Lyle, E A, Mellott, M J, Appleby, S D, Brady, S F, Stauffer, K J, Sisko, J T, Mao, S S, Veber, D F
Published in Thrombosis and haemostasis (01.10.1995)
Published in Thrombosis and haemostasis (01.10.1995)
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C6 Modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption
Isaacs, Richard C.A., Cutrona, Kellie J., Newton, Christina L., Sanderson, Philip E.J., Solinsky, Mark G., Baskin, Elizabeth P., Chen, I-Wu, Cooper, Carolyn M., Cook, Jacquelynn J., Gardell, Stephen J., Lewis, S.Dale, Lucas, Robert J., Lyle, Elizabeth A., Lynch, Joseph J., Naylor-Olsen, Adel M., Stranieri, Maria T., Vastag, Kari, Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
Published in Bioorganic & medicinal chemistry letters (07.07.1998)
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Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles
Isaacs, Richard C.A., Solinsky, Mark G., Cutrona, Kellie J., Newton, Christina L., Naylor-Olsen, Adel M., McMasters, Daniel R., Krueger, Julie A., Lewis, S. Dale, Lucas, Bobby J., Kuo, Lawrence C., Yan, Youwei, Lynch, J.J., Lyle, E.A.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Nonpeptide glycoprotein IIb/IIIa inhibitors. 8. Antiplatelet activity and oral antithrombotic efficacy of L-734,217
J J Cook, M A Holahan, E A Lyle, D R Ramjit, G R Sitko, M T Stranieri, R F Stupienski, 3rd, A A Wallace, E L Hand, J R Gehret, T Kothstein, M D Drag, G Y McCormick, J J Perkins, N C Ihle, M E Duggan, G D Hartman, R J Gould, J J Lynch, Jr
Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1996)
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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates
Sanderson, Philip E. J, Lyle, Terry A, Cutrona, Kellie J, Dyer, Dona L, Dorsey, Bruce D, McDonough, Colleen M, Naylor-Olsen, Adel M, Chen, I-Wu, Chen, Zhongguo, Cook, Jacquelynn J, Cooper, Carolyn M, Gardell, Stephen J, Hare, Timothy R, Krueger, Julie A, Lewis, S. Dale, Lin, Jiunn H, Lucas, Bobby J, Lyle, Elizabeth A, Lynch, Joseph J, Stranieri, Maria T, Vastag, Kari, Yan, Youwei, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (05.11.1998)
Published in Journal of medicinal chemistry (05.11.1998)
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Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position
Tucker, Thomas J, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Lucas, Bobby J, Sisko, Jack T, Lynch, Joseph J, Lyle, Elizabeth A, Baskin, Elizabeth P, Woltmann, Richard F, Appleby, Sandra D, Chen, I-Wu, Dancheck, Kimberley B, Naylor-Olsen, Adel M, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Bicyclic pyridones as potent, efficacious and orally bioavailable thrombin inhibitors
Coburn, C A, Rush, D M, Williams, P D, Homnick, C, Lyle, E A, Lewis, S D, Lucas, Jr, B J, Di Muzio-Mower, J M, Juliano, M, Krueger, J A, Vastag, K, Chen, I W, Vacca, J P
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
Published in Bioorganic & medicinal chemistry letters (15.05.2000)
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L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor
Sanderson, Philip E.J., Dyer, Dona L., Naylor-Olsen, Adel M., Vacca, Joseph P., Gardell, Steven J., Dale Lewis, S., Lucas, Bobby J., Lyle, Elizabeth A., Lynch, Joseph J., Mulichak, Anne M.
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
Published in Bioorganic & medicinal chemistry letters (17.06.1997)
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Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
Lyle, Terry A., Chen, Zhongguo, Appleby, Sandra D., Freidinger, Roger M., Gardell, Stephen J., Lewis, S.Dale, Li, Ying, Lyle, Elizabeth A., Lynch, Joseph J., Mulichak, Anne M., Ng, Assunta S., Naylor-Olsen, Adel M., Sanders, William M.
Published in Bioorganic & medicinal chemistry letters (07.01.1997)
Published in Bioorganic & medicinal chemistry letters (07.01.1997)
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Domain Exchange between Human Toll-like Receptors 1 and 6 Reveals a Region Required for Lipopeptide Discrimination
Omueti, Katherine O., Beyer, John M., Johnson, Christopher M., Lyle, Elizabeth A., Tapping, Richard I.
Published in The Journal of biological chemistry (04.11.2005)
Published in The Journal of biological chemistry (04.11.2005)
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Structure-based design of novel groups for use in the PI position of thrombin inhibitor scaffolds. Part 2. N-acetamidoimidazoles
ISAACS, Richard C. A, SOLINSKY, Mark G, YOUWEI YAN, LYNCH, J. J, LYLE, E. A, CUTRONA, Kellie J, NEWTON, Christina L, NAYLOR-OLSEN, Adel M, MC MASTERS, Daniel R, KRUEGER, Julie A, DALE LEWIS, S, LUCAS, Bobby J, KUO, Lawrence C
Published in Bioorganic & medicinal chemistry letters (2008)
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Published in Bioorganic & medicinal chemistry letters (2008)
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Toll-Like Receptor 2 Mediates Cellular Activation by the B Subunits of Type II Heat-Labile Enterotoxins
Hajishengallis, George, Tapping, Richard I, Martin, Michael H, Nawar, Hesham, Lyle, Elizabeth A, Russell, Michael W, Connell, Terry D
Published in Infection and Immunity (01.03.2005)
Published in Infection and Immunity (01.03.2005)
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Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines
Burgey, Christopher S, Robinson, Kyle A, Lyle, Terry A, Sanderson, Philip E. J, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Lyle, Elizabeth A, Williams, Peter D, Coburn, Craig A, Dorsey, Bruce D, Barrow, James C, Stranieri, Maria T, Holahan, Marie A, Sitko, Gary R, Cook, Jacquelynn J, McMasters, Daniel R, McDonough, Colleen M, Sanders, William M, Wallace, Audrey A, Clayton, Franklin C, Bohn, Dennis, Leonard, Yvonne M, Detwiler, Theodore J, Lynch, Joseph J, Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J, Shafer, Jules A, Vacca, Joseph P
Published in Journal of medicinal chemistry (13.02.2003)
Published in Journal of medicinal chemistry (13.02.2003)
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