Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway
Yuan, Bin, El Dana, Fouad, Ly, Stanley, Yan, Yuanqing, Ruvolo, Vivian, Shpall, Elizabeth J, Konopleva, Marina, Andreeff, Michael, Battula, Venkata Lokesh
Published in PloS one (30.11.2020)
Published in PloS one (30.11.2020)
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Journal Article
Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells
Ly, Stanley, Anand, Vivek, El-Dana, Fouad, Nguyen, Khoa, Cai, Yiming, Cai, Shirong, Piwnica-Worms, Helen, Tripathy, Debasish, Sahin, Aysegul A, Andreeff, Michael, Battula, Venkata Lokesh
Published in Journal for immunotherapy of cancer (01.03.2021)
Published in Journal for immunotherapy of cancer (01.03.2021)
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Journal Article
Abstract P5-06-10: Tumor microenvironment modulates ganglioside expression leading to immunosuppression in triple negative breast cancer
Anand, Vivek, El-Dana, Fouad, Ly, Stanley, Andreeff, Michael, Battula, Venkata Lokesh
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
TP-0184, a Novel FLT3-ALK2 Dual Inhibitor, Targets Amino Acid Transport and Biosynthesis in AML Cells and Sensitizes AML Cells to Chemotherapy and BCL2 Inhibition
Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason M, Warner, Steven L., Battula, Venkata Lokesh
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Anti-B7-H3 Antibody (T-1A5) Blocks Immunomodulatory Function of B7-H3 and Enhances NK Cell-Mediated Cytotoxicity Against Acute Myeloid Leukemia Cells
Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Grimm, Sabrina, Bühring, Hans-Jörg, Battula, Venkata Lokesh
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Evidence supporting a role for the immune checkpoint protein B7-H3 in NK cell-mediated cytotoxicity against AML
Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Jaggupilli, Appalaraju, Grimm, Sabrina, Konopleva, Marina, Bühring, Hans-Jörg, Battula, V. Lokesh
Published in Blood (05.05.2022)
Published in Blood (05.05.2022)
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Journal Article
Activin-like Kinase 2 (ALK2/ACVR1) Is a Resistance Factor and Therapeutic Vulnerability to FLT3 Inhibition in Acute Myeloid Leukemia
Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Anand, Vivek, Jaggupilli, Appalaraju, Borthakur, Gautam, Foulks, Jason M, Warner, Steven L., Battula, Venkata Lokesh
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Abstract 3248: B7-H3, an immune checkpoint protein is overexpressed in AML and the blocking monoclonal antibodies enhance NK cell-mediated apoptosis in AML cells
Ly, Stanley, Yuan, Bin, Grimm, Sabrina, Andreeff, Michael, Bühring, Hans-Jörg, Battula, Venkata Lokesh
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 1169: Characterization of a small molecule inhibitor for GD3 synthase (ST8SIA1), a novel target in breast cancer stem-like cells
Jappupilli, Appalaraju, Nguyen, Khoa, Ly, Stanley, Andreeff, Michael, Chelikani, Prashen, Battula, Venkata Lokesh
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 2322: Targeting glutamine transporter (ASCT2) inhibits metabolic stress-induced GD2+ cancer stem cell-like phenotype in triple-negative breast cancer
Jaggupilli, Appalaraju, Ly, Stanley, Nguyen, Khoa, Borkar, Roshan, Yuan, Bin, Piyarathna, Danthasinghe Waduge, Yan, Yuanqing, Piwnica-Worms, Helen, Manning, Henry Charles, Andreeff, Michael, Putluri, Nagireddy, Battula, Lokesh
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Metabolic stress induces GD2 + cancer stem cell-like phenotype in triple-negative breast cancer
Jaggupilli, Appalaraju, Ly, Stanley, Nguyen, Khoa, Anand, Vivek, Yuan, Bin, El-Dana, Fouad, Yan, Yuanqing, Arvanitis, Zoe, Piyarathna, Danthasinghe Waduge Badrajee, Putluri, Nagireddy, Piwnica-Worms, Helen, Manning, Henry Charles, Andreeff, Michael, Battula, V Lokesh
Published in British journal of cancer (09.03.2022)
Published in British journal of cancer (09.03.2022)
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Journal Article
Bone marrow stromal cells induce an ALDH.sup.+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-[beta]-p38-ALDH2 pathway
Yuan, Bin, El Dana, Fouad, Ly, Stanley, Yan, Yuanqing, Ruvolo, Vivian, Shpall, Elizabeth J, Konopleva, Marina, Andreeff, Michael, Battula, Venkata Lokesh, Papaccio, Gianpaolo
Published in PloS one (30.11.2020)
Published in PloS one (30.11.2020)
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Journal Article
Abstract 2040: Acute myeloid leukemia cells induce new bone formation by expanding osteoprogenitor niche in the bone marrow
Yuan, Bin, Ly, Stanley, Veletic, Ivo, Maldonado, Kiersten, Zhou, Xin, deCrombrugghe, Benoit, Andreeff, Michael, Battula, Venkata Lokesh
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax
Tyagi, Anudishi, Jaggupilli, Appalaraju, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Hegde, Venkatesh L, Anand, Vivek, Kumar, Bijender, Puppala, Mamta, Yin, Zheng, Wong, Stephen T C, Mollard, Alexis, Vankayalapati, Hariprasad, Foulks, Jason M, Warner, Steven L, Daver, Naval, Borthakur, Gautam, Battula, V Lokesh
Published in Leukemia (01.01.2024)
Published in Leukemia (01.01.2024)
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Journal Article
Poster: AML-326 Novel FLT3-ALK2 Dual Inhibitor TP-0184 Inhibits Leukemia Growth by Targeting Serine Biosynthesis in FLT3-ITD-Positive AML Cells
Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason, Warner, Steven, Battula, V Lokesh
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Journal Article
AML Cells Alter Bone Homeostasis By Promoting the Formation of Immature Bone and Resorption of Mature Bone That Supports Leukemia Progression
Tyagi, Anudishi, Yuan, Bin, Ly, Stanley, El-Dana, Fouad, Kuruvilla, Vinitha Mary, Zhang, Qi, Peterson, Christine B, Zhou, Xin, deCrombrugghe, Benoit, Andreeff, Michael, Konopleva, Marina, Amini, Behrang, Battula, Venkata Lokesh
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
AML-326 Novel FLT3-ALK2 Dual Inhibitor TP-0184 Inhibits Leukemia Growth by Targeting Serine Biosynthesis in FLT3-ITD-Positive AML Cells
Tyagi, Anudishi, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Jaggupilli, Appalaraju, Foulks, Jason, Warner, Steven, Battula, V Lokesh
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Journal Article
Poster: AML-327 Novel Anti–B7-H3 Blocking Antibody Enhances NK Cell–Mediated Cytotoxicity and Improves Outcomes in AML-Bearing Mice
Tyagi, Anudishi, Ly, Stanley, El-Dana, Fouad, Yuan, Bin, Jaggupilli, Appalaraju, Grimm, Sabrina, Bover, Laura, Buhring, Hans-Jorg, Battula, V Lokesh
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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