The developability of heteroaromatic and heteroaliphatic rings - do some have a better pedigree as potential drug molecules than others?
Ritchie, Timothy J, Macdonald, Simon J. F, Peace, Simon, Pickett, Stephen D, Luscombe, Christopher N
Published in MedChemComm (01.09.2012)
Published in MedChemComm (01.09.2012)
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Lead Optimization Using Matched Molecular Pairs: Inclusion of Contextual Information for Enhanced Prediction of hERG Inhibition, Solubility, and Lipophilicity
Papadatos, George, Alkarouri, Muhammad, Gillet, Valerie J, Willett, Peter, Kadirkamanathan, Visakan, Luscombe, Christopher N, Bravi, Gianpaolo, Richmond, Nicola J, Pickett, Stephen D, Hussain, Jameed, Pritchard, John M, Cooper, Anthony W. J, Macdonald, Simon J. F
Published in Journal of chemical information and modeling (25.10.2010)
Published in Journal of chemical information and modeling (25.10.2010)
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Using Physicochemical Measurements to Influence Better Compound Design
Bunally, Shenaz B., Luscombe, Christopher N., Young, Robert J.
Published in SLAS Discovery (01.09.2019)
Published in SLAS Discovery (01.09.2019)
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Book Review
Journal Article
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Chris, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Journal Article
QSAR workbench: automating QSAR modeling to drive compound design
Cox, Richard, Green, Darren V. S., Luscombe, Christopher N., Malcolm, Noj, Pickett, Stephen D.
Published in Journal of computer-aided molecular design (01.04.2013)
Published in Journal of computer-aided molecular design (01.04.2013)
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Journal Article
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
Amour, Augustin, Barton, Nick, Cooper, Anthony W. J, Inglis, Graham, Jamieson, Craig, Luscombe, Christopher N, Morrell, Josie, Peace, Simon, Perez, David, Rowland, Paul, Tame, Christopher J, Uddin, Sorif, Vitulli, Giovanni, Wellaway, Natalie
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
On the mechanism of human intestinal absorption
Abraham, Michael H., Zhao, Yuan H., Le, Joelle, Hersey, Anne, Luscombe, Christopher N., Reynolds, Derek P., Beck, Gordon, Sherborne, Brad, Cooper, Ian
Published in European journal of medicinal chemistry (01.07.2002)
Published in European journal of medicinal chemistry (01.07.2002)
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Journal Article
Increasing small molecule drug developability in sub-optimal chemical spaceElectronic supplementary information (ESI) available: Tables containing (a) the average values of all the descriptors for each clog P/Mw quadrant and developability class and (b) the VIP values with standard errors for each clog P/Mw quadrant and developability class are available. See DOI: 10.1039/c3md00003f
Ritchie, Timothy J, Macdonald, Simon J. F, Peace, Simon, Pickett, Stephen D, Luscombe, Christopher N
Year of Publication 27.03.2013
Year of Publication 27.03.2013
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