Discovery of (5S,6S,9R)‑5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro‑5H‑cyclohepta[b]pyridin-9-yl 4‑(2-oxo-2,3-dihydro‑1H‑imidazo[4,5‑b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine
Luo, Guanglin, Chen, Ling, Conway, Charles M., Denton, Rex, Keavy, Deborah, Signor, Laura, Kostich, Walter, Lentz, Kimberley A., Santone, Kenneth S., Schartman, Richard, Browning, Marc, Tong, Gary, Houston, John G., Dubowchik, Gene M., Macor, John E.
Published in Journal of medicinal chemistry (13.12.2012)
Published in Journal of medicinal chemistry (13.12.2012)
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Calcitonin gene-related peptide (CGRP) receptor antagonists: Pyridine as a replacement for a core amide group
Luo, Guanglin, Chen, Ling, Civiello, Rita, Pin, Sokhom S., Xu, Cen, Kostich, Walter, Kelley, Michelle, Conway, Charles M., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists
GUANGLIN LUO, MATTSON, Gail K, BRUCE, Marc A, WONG, Henry, MURPHY, Brian J, LONGHI, Daniel, ANTAL-ZIMANYI, Ildiko, POINDEXTER, Graham S
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
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β-Alanine dipeptides as MC4R agonists
RUEL, Réjean, HERPIN, Timothy F, THIBAULT, Carl, GUIXUE YU, ZIMANYI, Ildiko Antal, POINDEXTER, Graham S, MACOR, John E, IBEN, Lawrence, GUANGLIN LUO, MARTEL, Alain, MASON, Helen, MATTSON, Gail, POIRIER, Brigitte, RUEDIGER, Edward H, SHI, Dan
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
Heterocyclic aminopyrrolidine derivatives as melatoninergic agents
SUN, Li-Qiang, JIE CHEN, ORTIZ, Astrid, MOLSTAD, David, RYAN, Elaine, YELESWARAM, Krishnaswamy, CEN XU, GUANGLIN LUO, MATTSON, Ronald J, EPPERSON, James R, DESKUS, Jeffrey A, LI, Wen-Sen, TAKAKI, Katherine, HODGES, Donald B, IBEN, Lawrence, MAHLE, Cathy D
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors
Luo, Guanglin, Chen, Ling, Jacutin-Porte, Swanee, Han, Ying, Burton, Catherine R., Xiao, Hong, Krause, Carol M., Cao, Yang, Liu, Nengyin, Kish, Kevin, Lewis, Hal A., Macor, John E., Dubowchik, Gene M.
Published in Bioorganic & medicinal chemistry letters (01.02.2023)
Published in Bioorganic & medicinal chemistry letters (01.02.2023)
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Discovery of 2‑(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors
Hartz, Richard A., Ahuja, Vijay T., Luo, Guanglin, Chen, Ling, Sivaprakasam, Prasanna, Xiao, Hong, Krause, Carol M., Clarke, Wendy J., Xu, Songmei, Tokarski, John S., Kish, Kevin, Lewis, Hal, Szapiel, Nicolas, Ravirala, Ramu, Mutalik, Sayali, Nakmode, Deepa, Shah, Devang, Burton, Catherine R., Macor, John E., Dubowchik, Gene M.
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
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Journal Article
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase‑3 Inhibitors
Luo, Guanglin, Chen, Ling, Burton, Catherine R, Xiao, Hong, Sivaprakasam, Prasanna, Krause, Carol M, Cao, Yang, Liu, Nengyin, Lippy, Jonathan, Clarke, Wendy J, Snow, Kimberly, Raybon, Joseph, Arora, Vinod, Pokross, Matt, Kish, Kevin, Lewis, Hal A, Langley, David R, Macor, John E, Dubowchik, Gene M
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain
Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G, Knox, Ronald J, Matchett, Michele, Pieschl, Rick L, Post-Munson, Debra J, Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V, Senapati, Arun, Bristow, Linda J, Meanwell, Nicholas A, Thompson, Lorin A, Dzierba, Carolyn
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein‑2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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Journal Article
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na(V)1.7 Inhibitors for the Treatment of Pain
Luo, Guanglin, Chen, Ling, Easton, Amy, Newton, Amy, Bourin, Clotilde, Shields, Eric, Mosure, Kathy, Soars, Matthew G., Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Post-Munson, Debra J., Wang, Shuya, Herrington, James, Graef, John, Newberry, Kimberly, Sivarao, Digavalli V., Senapati, Arun, Bristow, Linda J., Meanwell, Nicholas A., Thompson, Lorin A., Dzierba, Carolyn
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.
Published in Journal of medicinal chemistry (24.03.2022)
Published in Journal of medicinal chemistry (24.03.2022)
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