The relationship between the chemistry and biological activity of the bisphosphonates
Ebetino, Frank H, Hogan, Anne-Marie L, Sun, Shuting, Tsoumpra, Maria K, Duan, Xuchen, Triffitt, James T, Kwaasi, Aaron A, Dunford, James E, Barnett, Bobby L, Oppermann, Udo, Lundy, Mark W, Boyde, Alan, Kashemirov, Boris A, McKenna, Charles E, Russell, R. Graham G
Published in Bone (New York, N.Y.) (01.07.2011)
Published in Bone (New York, N.Y.) (01.07.2011)
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Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice
Hokugo, Akishige, Kanayama, Keiichi, Sun, Shuting, Morinaga, Kenzo, Sun, Yujie, Wu, QingQing, Sasaki, Hodaka, Okawa, Hiroko, Evans, Courtney, Ebetino, Frank H., Lundy, Mark W., Sadrerafi, Keivan, McKenna, Charles E., Nishimura, Ichiro
Published in Bone (New York, N.Y.) (01.06.2019)
Published in Bone (New York, N.Y.) (01.06.2019)
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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
Roelofs, Anke J, Stewart, Charlotte A, Sun, Shuting, Błażewska, Katarzyna M, Kashemirov, Boris A, McKenna, Charles E, Russell, R Graham G, Rogers, Michael J, Lundy, Mark W, Ebetino, Frank H, Coxon, Fraser P
Published in Journal of bone and mineral research (01.04.2012)
Published in Journal of bone and mineral research (01.04.2012)
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Journal Article
Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Sun, Shuting, Błażewska, Katarzyna M, Kadina, Anastasia P, Kashemirov, Boris A, Duan, Xuchen, Triffitt, James T, Dunford, James E, Russell, R. Graham G, Ebetino, Frank H, Roelofs, Anke J, Coxon, Fraser P, Lundy, Mark W, McKenna, Charles E
Published in Bioconjugate chemistry (17.02.2016)
Published in Bioconjugate chemistry (17.02.2016)
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The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)
Lawson, Michelle A, Ebetino, Frank H, Mazur, Adam, Chantry, Andrew D, Paton‐Hough, Julia, Evans, Holly R, Lath, Darren, Tsoumpra, Maria K, Lundy, Mark W, Dobson, Roy LM, Quijano, Michael, Kwaasi, Aaron A, Dunford, James E, Duan, Xuchen, Triffitt, James T, Jeans, Gwyn, Russell, R Graham G
Published in Journal of bone and mineral research (01.09.2017)
Published in Journal of bone and mineral research (01.09.2017)
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Journal Article
A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation
Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B
Published in JBMR plus (01.04.2021)
Published in JBMR plus (01.04.2021)
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Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid
McKenna, Charles E, Kashemirov, Boris A, Błażewska, Katarzyna M, Mallard-Favier, Isabelle, Stewart, Charlotte A, Rojas, Javier, Lundy, Mark W, Ebetino, Frank H, Baron, Rudi A, Dunford, James E, Kirsten, Marie L, Seabra, Miguel C, Bala, Joy L, Marma, Mong S, Rogers, Michael J, Coxon, Fraser P
Published in Journal of medicinal chemistry (13.05.2010)
Published in Journal of medicinal chemistry (13.05.2010)
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Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation
Coffman, Abigail A, Basta‐Pljakic, Jelena, Guerra, Rosa M, Ebetino, Frank H, Lundy, Mark W, Majeska, Robert J, Schaffler, Mitchell B
Published in JBMR plus (01.07.2021)
Published in JBMR plus (01.07.2021)
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Journal Article
Bisphosphonate Binding Affinity Affects Drug Distribution in Both Intracortical and Trabecular Bone of Rabbits
Turek, John, Ebetino, F. Hal, Lundy, Mark W., Sun, Shuting, Kashemirov, Boris A., McKenna, Charles E., Gallant, Maxime A., Plotkin, Lilian I., Bellido, Teresita, Duan, Xuchen, Triffitt, James T., Russell, R. Graham G., Burr, David B., Allen, Matthew R.
Published in Calcified tissue international (01.03.2012)
Published in Calcified tissue international (01.03.2012)
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Journal Article
Design, Synthesis, and Antimicrobial Evaluation of a Novel Bone-Targeting Bisphosphonate-Ciprofloxacin Conjugate for the Treatment of Osteomyelitis Biofilms
Sedghizadeh, Parish P, Sun, Shuting, Junka, Adam F, Richard, Eric, Sadrerafi, Keivan, Mahabady, Susan, Bakhshalian, Neema, Tjokro, Natalia, Bartoszewicz, Marzenna, Oleksy, Monika, Szymczyk, Patrycja, Lundy, Mark W, Neighbors, Jeffrey D, Russell, R. Graham G, McKenna, Charles E, Ebetino, Frank H
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
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Journal Article
Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo
Roelofs, Anke J, Coxon, Fraser P, Ebetino, Frank H, Lundy, Mark W, Henneman, Zachary J, Nancollas, George H, Sun, Shuting, Blazewska, Katarzyna M, Bala, Joy Lynn F, Kashemirov, Boris A, Khalid, Aysha B, McKenna, Charles E, Rogers, Michael J
Published in Journal of bone and mineral research (01.03.2010)
Published in Journal of bone and mineral research (01.03.2010)
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Journal Article
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy
Russell, R Graham G, Xia, Zhidao, Dunford, James E, Oppermann, Udo, Kwaasi, Aaron, Hulley, Philippa A, Kavanagh, Kathryn L, Triffitt, James T, Lundy, Mark W, Phipps, Roger J, Barnett, Bobby L, Coxon, Fraser P, Rogers, Michael J, Watts, Nelson B, Ebetino, Frank H
Published in Annals of the New York Academy of Sciences (01.11.2007)
Published in Annals of the New York Academy of Sciences (01.11.2007)
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Journal Article
Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo
Fournier, Pierrick G J, Daubiné, Florence, Lundy, Mark W, Rogers, Michael J, Ebetino, Frank H, Clézardin, Philippe
Published in Cancer research (Chicago, Ill.) (01.11.2008)
Published in Cancer research (Chicago, Ill.) (01.11.2008)
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Journal Article
Risedronate did not block the maximal anabolic effect of PTH in aged rats
Yao, Wei, Su, Ming, Zhang, Qing, Tian, Xiaoyan, Setterberg, Rebecca B, Blanton, Cindy, Lundy, Mark W, Phipps, Roger, Jee, Webster S.S
Published in Bone (New York, N.Y.) (01.11.2007)
Published in Bone (New York, N.Y.) (01.11.2007)
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Journal Article
A mirror image pair of bisphosphonate analogs further demonstrates the mode of binding of the bisphosphonates in farnesyl pyrophosphate synthase
Ebetino, Frank H, Dunford, James E, Lundy, Mark W, Pozzi, Michele, Xia, Zhidao, Dobson, Roy, Quijano, Mike, Christian, Roze, Kashemirov, Boris A, McKenna, Charles E, Russell, Graham G, Barnett, Bobby L
Published in Bone (New York, N.Y.) (01.03.2008)
Published in Bone (New York, N.Y.) (01.03.2008)
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Journal Article
Fluorescently labeled risedronate and related analogs: Design and evaluation as imaging probes
Coxon, Fraser P, Bala, Joy L, Kashemirov, Boris A, Lundy, Mark W, Chen, Xiaolan, Xia, Zhidao, Dunford, James E, Russell, Graham G, Roelofs, Anke J, Rogers, Michael J, McKenna, Charles E, Ebetino, Frank H
Published in Bone (New York, N.Y.) (01.03.2008)
Published in Bone (New York, N.Y.) (01.03.2008)
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Journal Article
Bisphosphonates
RUSSELL, R. GRAHAM G., XIA, ZHIDAO, DUNFORD, JAMES E., OPPERMANN, UDO, KWAASI, AARON, HULLEY, PHILIPPA A., KAVANAGH, KATHRYN L., TRIFFITT, JAMES T., LUNDY, MARK W., PHIPPS, ROGER J., BARNETT, BOBBY L., COXON, FRASER P., ROGERS, MICHAEL J., WATTS, NELSON B., EBETINO, FRANK H.
Published in Annals of the New York Academy of Sciences (01.11.2007)
Published in Annals of the New York Academy of Sciences (01.11.2007)
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Journal Article
Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis
Soper, David L, Milbank, Jared B. J, Mieling, Glen E, Dirr, Michelle J, Kende, Andrew S, Cooper, Robin, Jee, Webster S. S, Yao, Wei, Chen, Jian Liang, Bodman, Mark, Lundy, Mark W, De, Biswanath, Stella, Mark E, Ebetino, Frank H, Wang, Yili, deLong, Mitchell A, Wos, John A
Published in Journal of medicinal chemistry (22.11.2001)
Published in Journal of medicinal chemistry (22.11.2001)
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Journal Article
Synthesis and Biological Evaluation of Prostaglandin-F Alkylphosphinic Acid Derivatives as Bone Anabolic Agents for the Treatment of Osteoporosis
Soper, David L, Milbank, Jared B. J, Mieling, Glen E, Dirr, Michelle J, Kende, Andrew S, Cooper, Robin, Jee, Webster S. S, Yao, Wei, Chen, Jian Liang, Bodman, Mark, Lundy, Mark W, De, Biswanath, Stella, Mark E, Ebetino, Frank H, Wang, Yili, deLong, Mitchell A, Wos, John A
Published in Journal of medicinal chemistry (22.11.2001)
Published in Journal of medicinal chemistry (22.11.2001)
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Journal Article
Fluoride therapy for osteoporosis: characterization of the skeletal response by serial measurements of serum alkaline phosphatase activity
Farley, S M, Wergedal, J E, Smith, L C, Lundy, M W, Farley, J R, Baylink, D J
Published in Metabolism, clinical and experimental (01.03.1987)
Published in Metabolism, clinical and experimental (01.03.1987)
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