Mechanism of Action of the Cell-Division Inhibitor PC190723: Modulation of FtsZ Assembly Cooperativity
Elsen, Nathaniel L, Lu, Jun, Parthasarathy, Gopal, Reid, John C, Sharma, Sujata, Soisson, Stephen M, Lumb, Kevin J
Published in Journal of the American Chemical Society (01.08.2012)
Published in Journal of the American Chemical Society (01.08.2012)
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Insights into activity and inhibition from the crystal structure of human O-GlcNAcase
Elsen, Nathaniel L, Patel, Sangita B, Ford, Rachael E, Hall, Dawn L, Hess, Fred, Kandula, Hari, Kornienko, Maria, Reid, John, Selnick, Harold, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J, Soisson, Stephen M, Klein, Daniel J
Published in Nature chemical biology (01.06.2017)
Published in Nature chemical biology (01.06.2017)
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Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U‑Shaped Binding Mode
Lu, Jun, Patel, Sangita, Sharma, Nandini, Soisson, Stephen M, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Lumb, Kevin J, Singh, Sheo B
Published in ACS chemical biology (19.09.2014)
Published in ACS chemical biology (19.09.2014)
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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction
Blevitt, Jonathan M, Hack, Michael D, Herman, Krystal L, Jackson, Paul F, Krawczuk, Paul J, Lebsack, Alec D, Liu, Annie X, Mirzadegan, Taraneh, Nelen, Marina I, Patrick, Aaron N, Steinbacher, Stefan, Milla, Marcos E, Lumb, Kevin J
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics
Tan, Christopher M, Therien, Alex G, Lu, Jun, Lee, Sang H, Caron, Alexandre, Gill, Charles J, Lebeau-Jacob, Christian, Benton-Perdomo, Liliana, Monteiro, João M, Pereira, Pedro M, Elsen, Nathaniel L, Wu, Jin, Deschamps, Kathleen, Petcu, Mihai, Wong, Simon, Daigneault, Etienne, Kramer, Susanne, Liang, Lianzhu, Maxwell, Eugene, Claveau, David, Vaillancourt, John, Skorey, Kathryn, Tam, John, Wang, Hao, Meredith, Timothy C, Sillaots, Susan, Wang-Jarantow, Lisa, Ramtohul, Yeeman, Langlois, Eric, Landry, France, Reid, John C, Parthasarathy, Gopal, Sharma, Sujata, Baryshnikova, Anastasia, Lumb, Kevin J, Pinho, Mariana G, Soisson, Stephen M, Roemer, Terry
Published in Science translational medicine (21.03.2012)
Published in Science translational medicine (21.03.2012)
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Identification of small-molecule protein-protein interaction inhibitors for NKG2D
Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2023)
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Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Su, Hua-Poo, Rickert, Keith, Burlein, Christine, Narayan, Kartik, Bukhtiyarova, Marina, Hurzy, Danielle M., Stump, Craig A., Zhang, Xufang, Reid, John, Krasowska-Zoladek, Alicja, Tummala, Srivanya, Shipman, Jennifer M., Kornienko, Maria, Lemaire, Peter A., Krosky, Daniel, Heller, Amanda, Achab, Abdelghani, Chamberlin, Chad, Saradjian, Peter, Sauvagnat, Berengere, Yang, Xianshu, Ziebell, Michael R., Nickbarg, Elliott, Sanders, John M., Bilodeau, Mark T., Carroll, Steven S., Lumb, Kevin J., Soisson, Stephen M., Henze, Darrell A., Cooke, Andrew J.
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (17.01.2017)
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Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer
Clayton, Gina M., Klein, Daniel J., Rickert, Keith W., Patel, Sangita B., Kornienko, Maria, Zugay-Murphy, Joan, Reid, John C., Tummala, Srivanya, Sharma, Sujata, Singh, Sheo B., Miesel, Lynn, Lumb, Kevin J., Soisson, Stephen M.
Published in The Journal of biological chemistry (22.11.2013)
Published in The Journal of biological chemistry (22.11.2013)
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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M
Published in Nature structural & molecular biology (01.07.2017)
Published in Nature structural & molecular biology (01.07.2017)
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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4
Allen, Samantha J., Parthasarathy, Gopal, Darke, Paul L., Diehl, Ronald E., Ford, Rachael E., Hall, Dawn L., Johnson, Scott A., Reid, John C., Rickert, Keith W., Shipman, Jennifer M., Soisson, Stephen M., Zuck, Paul, Munshi, Sanjeev K., Lumb, Kevin J.
Published in The Journal of biological chemistry (14.08.2015)
Published in The Journal of biological chemistry (14.08.2015)
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Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway
Kutilek, Victoria D, Andrews, Christine L, Richards, Matthew P, Xu, Zangwei, Sun, Tianxiao, Chen, Yiping, Hashke, Andrew, Smotrov, Nadya, Fernandez, Rafael, Nickbarg, Elliott B, Chamberlin, Chad, Sauvagnat, Berengere, Curran, Patrick J, Boinay, Ryan, Saradjian, Peter, Allen, Samantha J, Byrne, Noel, Elsen, Nathaniel L, Ford, Rachael E, Hall, Dawn L, Kornienko, Maria, Rickert, Keith W, Sharma, Sujata, Shipman, Jennifer M, Lumb, Kevin J, Coleman, Kevin, Dandliker, Peter J, Kariv, Ilona, Beutel, Bruce
Published in Journal of biomolecular screening (01.07.2016)
Published in Journal of biomolecular screening (01.07.2016)
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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation
Sunami, Tomoko, Byrne, Noel, Diehl, Ronald E., Funabashi, Kaoru, Hall, Dawn L., Ikuta, Mari, Patel, Sangita B., Shipman, Jennifer M., Smith, Robert F., Takahashi, Ikuko, Zugay-Murphy, Joan, Iwasawa, Yoshikazu, Lumb, Kevin J., Munshi, Sanjeev K., Sharma, Sujata
Published in The Journal of biological chemistry (12.02.2010)
Published in The Journal of biological chemistry (12.02.2010)
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Discovery of a 5H-Benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) Inhibitor of c-Met Kinase for the Treatment of Cancer
Katz, Jason D, Jewell, James P, Guerin, David J, Lim, Jongwon, Dinsmore, Christopher J, Deshmukh, Sujal V, Pan, Bo-Sheng, Marshall, C. Gary, Lu, Wei, Altman, Michael D, Dahlberg, William K, Davis, Lenora, Falcone, Danielle, Gabarda, Ana E, Hang, Gaozhen, Hatch, Harold, Holmes, Rachael, Kunii, Kaiko, Lumb, Kevin J, Lutterbach, Bart, Mathvink, Robert, Nazef, Naim, Patel, Sangita B, Qu, Xianlu, Reilly, John F, Rickert, Keith W, Rosenstein, Craig, Soisson, Stephen M, Spencer, Kerrie B, Szewczak, Alexander A, Walker, Deborah, Wang, Wenxian, Young, Jonathan, Zeng, Qinwen
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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A Novel Long-Acting Selective Neuropeptide Y2 Receptor Polyethylene Glycol-Conjugated Peptide Agonist Reduces Food Intake and Body Weight and Improves Glucose Metabolism in Rodents
Ortiz, Astrid A, Milardo, Lucinda F, DeCarr, Lynn B, Buckholz, Thomas M, Mays, Michelle R, Claus, Thomas H, Livingston, James N, Mahle, Cathy D, Lumb, Kevin J
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase
Soisson, Stephen M, Patel, Sangita B, Abeywickrema, Pravien D, Byrne, Noel J, Diehl, Ronald E, Hall, Dawn L, Ford, Rachael E, Reid, John C, Rickert, Keith W, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J
Published in BMC structural biology (11.06.2010)
Published in BMC structural biology (11.06.2010)
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Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met
Rickert, Keith W., Patel, Sangita B., Allison, Timothy J., Byrne, Noel J., Darke, Paul L., Ford, Rachael E., Guerin, David J., Hall, Dawn L., Kornienko, Maria, Lu, Jun, Munshi, Sanjeev K., Reid, John C., Shipman, Jennifer M., Stanton, Elizabeth F., Wilson, Kevin J., Young, Jonathon R., Soisson, Stephen M., Lumb, Kevin J.
Published in The Journal of biological chemistry (01.04.2011)
Published in The Journal of biological chemistry (01.04.2011)
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