α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
Tran, Hien T., Chung, Charlotte Hiu-Yan, Iba, Michiyo, Zhang, Bin, Trojanowski, John Q., Luk, Kelvin C., Lee, Virginia M.Y.
Published in Cell reports (Cambridge) (26.06.2014)
Published in Cell reports (Cambridge) (26.06.2014)
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Journal Article
A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology
Wie, Jinhong, Liu, Zhenjiang, Song, Haikun, Tropea, Thomas F., Yang, Lu, Wang, Huanhuan, Liang, Yuling, Cang, Chunlei, Aranda, Kimberly, Lohmann, Joey, Yang, Jing, Lu, Boxun, Chen-Plotkin, Alice S., Luk, Kelvin C., Ren, Dejian
Published in Nature (London) (18.03.2021)
Published in Nature (London) (18.03.2021)
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Journal Article
Progressive Aggregation of Alpha-Synuclein and Selective Degeneration of Lewy Inclusion-Bearing Neurons in a Mouse Model of Parkinsonism
Osterberg, Valerie R., Spinelli, Kateri J., Weston, Leah J., Luk, Kelvin C., Woltjer, Randall L., Unni, Vivek K.
Published in Cell reports (Cambridge) (03.03.2015)
Published in Cell reports (Cambridge) (03.03.2015)
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Journal Article
Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology
Manfredsson, Fredric P., Luk, Kelvin C., Benskey, Matthew J., Gezer, Aysegul, Garcia, Joanna, Kuhn, Nathan C., Sandoval, Ivette M., Patterson, Joseph R., O'Mara, Alana, Yonkers, Reid, Kordower, Jeffrey H.
Published in Neurobiology of disease (01.04.2018)
Published in Neurobiology of disease (01.04.2018)
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Journal Article
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
Luk, Kelvin C, Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M.-Y
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.11.2009)
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Journal Article
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, O'Rourke, Caroline M, He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B
Published in Science (American Association for the Advancement of Science) (20.11.2020)
Published in Science (American Association for the Advancement of Science) (20.11.2020)
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Journal Article
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
Paumier, Katrina L, Luk, Kelvin C, Manfredsson, Fredric P, Kanaan, Nicholas M, Lipton, Jack W, Collier, Timothy J, Steece-Collier, Kathy, Kemp, Christopher J, Celano, Stephanie, Schulz, Emily, Sandoval, Ivette M, Fleming, Sheila, Dirr, Elliott, Polinski, Nicole K, Trojanowski, John Q, Lee, Virginia M, Sortwell, Caryl E
Published in Neurobiology of disease (01.10.2015)
Published in Neurobiology of disease (01.10.2015)
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Journal Article
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Volpicelli-Daley, Laura A., Luk, Kelvin C., Patel, Tapan P., Tanik, Selcuk A., Riddle, Dawn M., Stieber, Anna, Meaney, David F., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Neuron (Cambridge, Mass.) (06.10.2011)
Published in Neuron (Cambridge, Mass.) (06.10.2011)
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Journal Article
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo
Wu, Qihui, Shaikh, Muhammad A., Meymand, Emily S., Zhang, Bin, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Acta neuropathologica (01.12.2020)
Published in Acta neuropathologica (01.12.2020)
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Journal Article
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages
Haenseler, Walther, Zambon, Federico, Lee, Heyne, Vowles, Jane, Rinaldi, Federica, Duggal, Galbha, Houlden, Henry, Gwinn, Katrina, Wray, Selina, Luk, Kelvin C., Wade-Martins, Richard, James, William S., Cowley, Sally A.
Published in Scientific reports (21.08.2017)
Published in Scientific reports (21.08.2017)
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Journal Article
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Duffy, Megan F, Collier, Timothy J, Patterson, Joseph R, Kemp, Christopher J, Luk, Kelvin C, Tansey, Malú G, Paumier, Katrina L, Kanaan, Nicholas M, Fischer, D Luke, Polinski, Nicole K, Barth, Olivia L, Howe, Jacob W, Vaikath, Nishant N, Majbour, Nour K, El-Agnaf, Omar M A, Sortwell, Caryl E
Published in Journal of neuroinflammation (01.05.2018)
Published in Journal of neuroinflammation (01.05.2018)
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Journal Article
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
Patterson, Joseph R., Duffy, Megan F., Kemp, Christopher J., Howe, Jacob W., Collier, Timothy J., Stoll, Anna C., Miller, Kathryn M., Patel, Pooja, Levine, Nathan, Moore, Darren J., Luk, Kelvin C., Fleming, Sheila M., Kanaan, Nicholas M., Paumier, Katrina L., El-Agnaf, Omar M.A., Sortwell, Caryl E.
Published in Neurobiology of disease (01.10.2019)
Published in Neurobiology of disease (01.10.2019)
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Journal Article
Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
Luk, Kelvin C., Covell, Dustin J., Kehm, Victoria M., Zhang, Bin, Song, Insung Y., Byrne, Matthew D., Pitkin, Rose M., Decker, Samantha C., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Cell reports (Cambridge) (20.09.2016)
Published in Cell reports (Cambridge) (20.09.2016)
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Journal Article
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice
Uemura, Norihito, Marotta, Nicholas P., Ara, Jahan, Meymand, Emily S., Zhang, Bin, Kameda, Hiroshi, Koike, Masato, Luk, Kelvin C., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Nature communications (28.10.2023)
Published in Nature communications (28.10.2023)
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Journal Article
Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice
Johnson, Michaela E., Bergkvist, Liza, Stetzik, Lucas, Steiner, Jennifer A., Meyerdirk, Lindsay, Schulz, Emily, Wolfrum, Emily, Luk, Kelvin C., Wesson, Daniel W., Krainc, Dimitri, Brundin, Patrik
Published in Neurobiology of disease (01.11.2021)
Published in Neurobiology of disease (01.11.2021)
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Journal Article
TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease
Zhu, Guixin, Harischandra, Dilshan S., Ghaisas, Shivani, Zhang, Pengfei, Prall, Wil, Huang, Liangqian, Maghames, Chantal, Guo, Lili, Luna, Esteban, Mack, Korrie L., Torrente, Mariana P., Luk, Kelvin C., Shorter, James, Yang, Xiaolu
Published in Cell reports (Cambridge) (01.12.2020)
Published in Cell reports (Cambridge) (01.12.2020)
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Journal Article
Low-dye taping may enhance physical performance and muscle activation in basketball players with overpronated feet
Ho, Indy M. K, Weldon, Anthony, Yeung, Natalia C. Y, Luk, Jim T. C
Published in PloS one (11.10.2022)
Published in PloS one (11.10.2022)
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Journal Article
Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions
Stoll, Anna C., Kemp, Christopher J., Patterson, Joseph R., Howe, Jacob W., Steece-Collier, Kathy, Luk, Kelvin C., Sortwell, Caryl E., Benskey, Matthew J.
Published in Neurobiology of disease (01.02.2024)
Published in Neurobiology of disease (01.02.2024)
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Journal Article
Cost-effectiveness of internet-supported cognitive behavioral therapy for university students with anxiety symptoms: A Markov-model analysis
You, Joyce H S, Luk, Scotty W C, Chow, Dilys Y W, Jiang, Xinchan, Mak, Arthur D P, Mak, Winnie W S
Published in PloS one (05.05.2022)
Published in PloS one (05.05.2022)
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