Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids
Obeng, Samuel, Kamble, Shyam H, Reeves, Morgan E, Restrepo, Luis F, Patel, Avi, Behnke, Mira, Chear, Nelson J.-Y, Ramanathan, Surash, Sharma, Abhisheak, León, Francisco, Hiranita, Takato, Avery, Bonnie A, McMahon, Lance R, McCurdy, Christopher R
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
Activity of Mitragyna speciosa (“Kratom”) Alkaloids at Serotonin Receptors
León, Francisco, Obeng, Samuel, Mottinelli, Marco, Chen, Yiming, King, Tamara I, Berthold, Erin C, Kamble, Shyam H, Restrepo, Luis F, Patel, Avi, Gamez-Jimenez, Lea R, Lopera-Londoño, Carolina, Hiranita, Takato, Sharma, Abhisheak, Hampson, Aidan J, Canal, Clinton E, McMahon, Lance R, McCurdy, Christopher R
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Treatment patterns in fibromyalgia including the use of opioids
Valladales‐Restrepo, Luis F., Oyuela‐Gutiérrez, María C., Alzate‐García, Mariana, Osorio‐Rodas, Isabella, Quintero‐Flórez, Valentina, Restrepo‐Muñoz, Juan F., Suárez‐Cardona, Julián A., Barroso‐Fernandes, Sergio T., Machado‐Alba, Jorge E.
Published in Musculoskeletal care (01.03.2023)
Published in Musculoskeletal care (01.03.2023)
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Journal Article
Treatment patterns of antidiabetic and kidney protective therapies among patients with type 2 diabetes mellitus and chronic kidney disease in Colombia. The KDICO descriptive study
Machado-Duque, Manuel E, Gaviria-Mendoza, Andres, Valladales-Restrepo, Luis F, Franco, Juan Sebastian, de Rosario Forero, Maria, Vizcaya, David, Machado-Alba, Jorge E
Published in Diabetology and metabolic syndrome (04.07.2023)
Published in Diabetology and metabolic syndrome (04.07.2023)
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Journal Article
Exploring the Chemistry of Alkaloids from Malaysian Mitragyna speciosa (Kratom) and the Role of Oxindoles on Human Opioid Receptors
Chear, Nelson Jeng-Yeou, León, Francisco, Sharma, Abhisheak, Kanumuri, Siva Rama Raju, Zwolinski, Grant, Abboud, Khalil A, Singh, Darshan, Restrepo, Luis F, Patel, Avi, Hiranita, Takato, Ramanathan, Surash, Hampson, Aidan J, McMahon, Lance R, McCurdy, Christopher R
Published in Journal of natural products (Washington, D.C.) (23.04.2021)
Published in Journal of natural products (Washington, D.C.) (23.04.2021)
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Journal Article
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ -Opioid Receptor and Opioid-Like Behavioral Effects in Rats
Obeng, Samuel, Wilkerson, Jenny L, León, Francisco, Reeves, Morgan E, Restrepo, Luis F, Gamez-Jimenez, Lea R, Patel, Avi, Pennington, Anna E, Taylor, Victoria A, Ho, Nicholas P, Braun, Tobias, Fortner, John D, Crowley, Morgan L, Williamson, Morgan R, Pallares, Victoria L C, Mottinelli, Marco, Lopera-Londoño, Carolina, McCurdy, Christopher R, McMahon, Lance R, Hiranita, Takato
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2021)
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Journal Article
The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats
Hiranita, Takato, Leon, Francisco, Felix, Jasmine S., Restrepo, Luis F., Reeves, Morgan E., Pennington, Anna E., Obeng, Samuel, Avery, Bonnie A., McCurdy, Christopher R., McMahon, Lance R., Wilkerson, Jenny L.
Published in Psychopharmacology (01.09.2019)
Published in Psychopharmacology (01.09.2019)
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Journal Article
The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
Berthold, Erin C, Kamble, Shyam H, Raju, Kanumuri S, Kuntz, Michelle A, Senetra, Alexandria S, Mottinelli, Marco, León, Francisco, Restrepo, Luis F, Patel, Avi, Ho, Nicholas P, Hiranita, Takato, Sharma, Abhisheak, McMahon, Lance R, McCurdy, Christopher R
Published in Drug metabolism and disposition (01.02.2022)
Published in Drug metabolism and disposition (01.02.2022)
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Journal Article
The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α2 receptor activity in vitro and in vivo
Obeng, Samuel, Crowley, Morgan L., Mottinelli, Marco, León, Francisco, Zuarth Gonzalez, Julio D., Chen, Yiming, Gamez-Jimenez, Lea R., Restrepo, Luis F., Ho, Nicholas P., Patel, Avi, Martins Rocha, Joelma, Alvarez, Manuel A., Thadisetti, Amsha M., Park, Chai R., Pallares, Victoria L.C., Milner, Megan J., Canal, Clinton E., Hampson, Aidan J., McCurdy, Christopher R., McMahon, Lance R., Wilkerson, Jenny L., Hiranita, Takato
Published in European journal of pharmacology (05.10.2024)
Published in European journal of pharmacology (05.10.2024)
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Journal Article
The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α 2 receptor activity in vitro and in vivo
Obeng, Samuel, Crowley, Morgan L, Mottinelli, Marco, León, Francisco, Zuarth Gonzalez, Julio D, Chen, Yiming, Gamez-Jimenez, Lea R, Restrepo, Luis F, Ho, Nicholas P, Patel, Avi, Martins Rocha, Joelma, Alvarez, Manuel A, Thadisetti, Amsha M, Park, Chai R, Pallares, Victoria L C, Milner, Megan J, Canal, Clinton E, Hampson, Aidan J, McCurdy, Christopher R, McMahon, Lance R, Wilkerson, Jenny L, Hiranita, Takato
Published in European journal of pharmacology (05.10.2024)
Published in European journal of pharmacology (05.10.2024)
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Journal Article
Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats
Kamble, Shyam H, Obeng, Samuel, León, Francisco, Restrepo, Luis F, King, Tamara I, Berthold, Erin C, Kanumuri, Siva Rama Raju, Gamez-Jimenez, Lea R, Pallares, Victoria L C, Patel, Avi, Ho, Nicholas P, Hampson, Aidan, McCurdy, Christopher R, McMahon, Lance R, Wilkerson, Jenny L, Sharma, Abhisheak, Hiranita, Takato
Published in The Journal of pharmacology and experimental therapeutics (01.06.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2023)
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Journal Article
The Effects of Morphine, Baclofen, and Buspirone Alone and in Combination on Schedule-Controlled Responding and Hot Plate Antinociception in Rats
Wilkerson, Jenny L, Felix, Jasmine S, Restrepo, Luis F, Ansari, Mohd Imran, Coop, Andrew, McMahon, Lance R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2019)
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Journal Article
Interactive Effects of µ -Opioid and Adrenergic- α 2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine
Obeng, Samuel, Leon, Francisco, Patel, Avi, Zuarth Gonzalez, Julio D, Chaves Da Silva, Lucas, Restrepo, Luis F, Gamez-Jimenez, Lea R, Ho, Nicholas P, Guerrero Calvache, Maria P, Pallares, Victoria L C, Helmes, Justin A, Shiomitsu, Sakura K, Soto, Paul L, McCurdy, Christopher R, McMahon, Lance R, Wilkerson, Jenny L, Hiranita, Takato
Published in The Journal of pharmacology and experimental therapeutics (01.12.2022)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2022)
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Journal Article
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats
Crowley, Morgan L., Restrepo, Luis F., Gamez-Jimenez, Lea R., Patel, Avi, Braun, Tobias, Pallares, Victoria L.C., Ho, Nicholas P., Reeves, Morgan E., McCurdy, Christopher R., McMahon, Lance R., Hiranita, Takato
Published in Journal of pharmacological and toxicological methods (01.09.2021)
Published in Journal of pharmacological and toxicological methods (01.09.2021)
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Journal Article
Gestión de la Atención Primaria de la Salud en un contexto de mercado: análisis de caso en un hospital público de Bogotá, Colombia, 2008-2011
Zuluaga Salazar, Sandra Milena, Restrepo, Juan Fernando, Otalvaro Castro, Gabriel Jaime, Blanco Santamaría, Daniel
Published in Revista de la Facultad Nacional de Salud Pública (01.09.2016)
Published in Revista de la Facultad Nacional de Salud Pública (01.09.2016)
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Journal Article
The effect of slurry preparation methods on biaxial flexural strength of dental porcelain
Pelaez-Vargas, Alejandro, DDS, MSc, Dussan, Jaime A., DDS, Restrepo-Tamayo, Luis F., DDS, Paucar, Carlos, MSc, Ferreira, Jorge A., MS, Monteiro, Fernando J., Eng. MSc, PhD
Published in The Journal of prosthetic dentistry (01.05.2011)
Published in The Journal of prosthetic dentistry (01.05.2011)
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Journal Article
Prevalencia de Parasitosis Intestinales y Factores Asociados en un Corregimiento de la Costa Atlántica Colombiana
Agudelo-Lopez, Sonia, Gómez-Rodríguez, Lucila, Coronado, Xiomara, Orozco, Adalina, Valencia-Gutierrez, Carlos A., Restrepo-Betancur, Luis F., Galvis-Gómez, Luisa A., Botero-Palacio, Luz E.
Published in Revista de salud pública (Bogotá, Colombia) (01.10.2008)
Published in Revista de salud pública (Bogotá, Colombia) (01.10.2008)
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Journal Article