Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
Grein, Fabian, Müller, Anna, Scherer, Katharina M., Liu, Xinliang, Ludwig, Kevin C., Klöckner, Anna, Strach, Manuel, Sahl, Hans-Georg, Kubitscheck, Ulrich, Schneider, Tanja
Published in Nature communications (19.03.2020)
Published in Nature communications (19.03.2020)
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Journal Article
The Lasso Peptide Siamycin‑I Targets Lipid II at the Gram-Positive Cell Surface
Tan, Stephanie, Ludwig, Kevin C, Müller, Anna, Schneider, Tanja, Nodwell, Justin R
Published in ACS chemical biology (17.05.2019)
Published in ACS chemical biology (17.05.2019)
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Journal Article
An antibiotic from an uncultured bacterium binds to an immutable target
Shukla, Rhythm, Peoples, Aaron J., Ludwig, Kevin C., Maity, Sourav, Derks, Maik G.N., De Benedetti, Stefania, Krueger, Annika M., Vermeulen, Bram J.A., Harbig, Theresa, Lavore, Francesca, Kumar, Raj, Honorato, Rodrigo V., Grein, Fabian, Nieselt, Kay, Liu, Yangping, Bonvin, Alexandre M.J.J., Baldus, Marc, Kubitscheck, Ulrich, Breukink, Eefjan, Achorn, Catherine, Nitti, Anthony, Schwalen, Christopher J., Spoering, Amy L., Ling, Losee Lucy, Hughes, Dallas, Lelli, Moreno, Roos, Wouter H., Lewis, Kim, Schneider, Tanja, Weingarth, Markus
Published in Cell (14.09.2023)
Published in Cell (14.09.2023)
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Journal Article
Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin
Wirtz, Daniel A., Ludwig, Kevin C., Arts, Melina, Marx, Carina E., Krannich, Sebastian, Barac, Paul, Kehraus, Stefan, Josten, Michaele, Henrichfreise, Beate, Müller, Anna, König, Gabriele M., Peoples, Aaron J., Nitti, Anthony, Spoering, Amy L., Ling, Losee L., Lewis, Kim, Crüsemann, Max, Schneider, Tanja
Published in Angewandte Chemie International Edition (07.06.2021)
Published in Angewandte Chemie International Edition (07.06.2021)
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Journal Article
The Dual Mode of Antibacterial Action of the Synthetic Small Molecule DCAP Involves Lipid II Binding
Ludwig, Kevin C., Puls, Jan-Samuel, Matos de Opitz, Cruz L., Innocenti, Paolo, Daniel, Jan-Martin, Bornikoel, Jan, Arts, Melina, Krannich, Sebastian, Straetener, Jan, Brajtenbach, Dominik, Henrichfreise, Beate, Sass, Peter, Mueller, Anna, Martin, Nathaniel I., Brötz-Oesterhelt, Heike, Kubitscheck, Ulrich, Grein, Fabian, Schneider, Tanja
Published in Journal of the American Chemical Society (11.09.2024)
Published in Journal of the American Chemical Society (11.09.2024)
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Journal Article
THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates
Reithuber, Elisabeth, Wixe, Torbjörn, Ludwig, Kevin C., Müller, Anna, Uvell, Hanna, Grein, Fabian, Lindgren, Anders E. G., Muschiol, Sandra, Nannapaneni, Priyanka, Eriksson, Anna, Schneider, Tanja, Normark, Staffan, Henriques-Normark, Birgitta, Almqvist, Fredrik, Mellroth, Peter
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.2021)
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Journal Article
Synthesis of Bisindole Alkaloids and Their Mode of Action against Methicillin-Resistant Staphylococcus Aureus
Adeniyi, Emmanuel T., Kruppa, Marco, De Benedetti, Stefania, Ludwig, Kevin C., Krisilia, Violetta, Wassenberg, Tobias R., Both, Melissa, Schneider, Tanja, Müller, Thomas J. J., Kalscheuer, Rainer
Published in ACS infectious diseases (14.06.2024)
Published in ACS infectious diseases (14.06.2024)
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Journal Article
Impacts of NaHCO3 on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO3-Responsive versus NaHCO3-Non-Responsive Phenotypes
Ersoy, Selvi C., Chan, Liana C., Yeaman, Michael R., Chambers, Henry F., Proctor, Richard A., Ludwig, Kevin C., Schneider, Tanja, Manna, Adhar C., Cheung, Ambrose, Bayer, Arnold S.
Published in Antibiotics (Basel) (30.03.2022)
Published in Antibiotics (Basel) (30.03.2022)
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Journal Article
Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin
Wirtz, Daniel A., Ludwig, Kevin C., Arts, Melina, Marx, Carina E., Krannich, Sebastian, Barac, Paul, Kehraus, Stefan, Josten, Michaele, Henrichfreise, Beate, Müller, Anna, König, Gabriele M., Peoples, Aaron J., Nitti, Anthony, Spoering, Amy L., Ling, Losee L., Lewis, Kim, Crüsemann, Max, Schneider, Tanja
Published in Angewandte Chemie (07.06.2021)
Published in Angewandte Chemie (07.06.2021)
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Journal Article
The success of stainless steel crowns placed with the Hall technique
Ludwig, Kevin H., DDS, Fontana, Margherita, DDS, PhD, Vinson, LaQuia A., DDS, MPH, Platt, Jeffrey A., DDS, MS, Dean, Jeffrey A., DDS, MSD
Published in The Journal of the American Dental Association (1939) (01.12.2014)
Published in The Journal of the American Dental Association (1939) (01.12.2014)
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Journal Article
Investigations on the Degradation of the Bile Salt Cholate via the 9,10-Seco-Pathway Reveals the Formation of a Novel Recalcitrant Steroid Compound by a Side Reaction in Sphingobium sp. Strain Chol11
Feller, Franziska Maria, Eilebrecht, Sebastian, Nedielkov, Ruslan, Yücel, Onur, Alvincz, Julia, Salinas, Gabriela, Ludwig, Kevin Christopher, Möller, Heiko, Philipp, Bodo
Published in Microorganisms (Basel) (14.10.2021)
Published in Microorganisms (Basel) (14.10.2021)
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Journal Article
A Novel Steroid-Coenzyme A Ligase from Novosphingobium sp. Strain Chol11 Is Essential for an Alternative Degradation Pathway for Bile Salts
Yücel, Onur, Holert, Johannes, Ludwig, Kevin Christopher, Thierbach, Sven, Philipp, Bodo
Published in Applied and environmental microbiology (01.01.2018)
Published in Applied and environmental microbiology (01.01.2018)
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Journal Article
Impacts of NaHCO 3 on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO 3 -Responsive versus NaHCO 3 -Non-Responsive Phenotypes
Ersoy, Selvi C, Chan, Liana C, Yeaman, Michael R, Chambers, Henry F, Proctor, Richard A, Ludwig, Kevin C, Schneider, Tanja, Manna, Adhar C, Cheung, Ambrose, Bayer, Arnold S
Published in Antibiotics (Basel) (30.03.2022)
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Published in Antibiotics (Basel) (30.03.2022)
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Authors’ response
Ludwig, Kevin H., Fontana, Margherita, Vinson, LaQuia A., Platt, Jeffrey A., Dean, Jeffrey A.
Published in The Journal of the American Dental Association (1939) (01.07.2015)
Published in The Journal of the American Dental Association (1939) (01.07.2015)
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Journal Article
Ca 2+ -Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
Grein, Fabian, Müller, Anna, Scherer, Katharina M, Liu, Xinliang, Ludwig, Kevin C, Klöckner, Anna, Strach, Manuel, Sahl, Hans-Georg, Kubitscheck, Ulrich, Schneider, Tanja
Published in Nature communications (19.03.2020)
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Published in Nature communications (19.03.2020)
Journal Article
Authors' response
Ludwig, Kevin H, Fontana, Margherita, Vinson, LaQuia A, Platt, Jeffrey A, Dean, Jeffrey A
Published in The Journal of the American Dental Association (1939) (01.07.2015)
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Published in The Journal of the American Dental Association (1939) (01.07.2015)
Journal Article
Authors' response
Ludwig, Kevin H, Fontana, Margherita, Vinson, LaQuia A, Platt, Jeffrey A, Dean, Jeffrey A
Published in The Journal of the American Dental Association (1939) (01.07.2015)
Published in The Journal of the American Dental Association (1939) (01.07.2015)
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Journal Article