Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson’s disease mouse model
Fang, Tracy-Shi Zhang, Sun, Yu, Pearce, Andrew C., Eleuteri, Simona, Kemp, Mark, Luckhurst, Christopher A., Williams, Rachel, Mills, Ross, Almond, Sarah, Burzynski, Laura, Márkus, Nóra M., Lelliott, Christopher J., Karp, Natasha A., Adams, David J., Jackson, Stephen P., Zhao, Jin-Feng, Ganley, Ian G., Thompson, Paul W., Balmus, Gabriel, Simon, David K.
Published in Nature communications (13.11.2023)
Published in Nature communications (13.11.2023)
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Journal Article
Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease
Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
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Journal Article
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease
Ladduwahetty, Tammy, Lee, Matthew R., Maillard, Michel C., Cachope, Roger, Todd, Daniel, Barnes, Michael, Beaumont, Vahri, Chauhan, Alka, Gallati, Caroline, Haughan, Alan F., Kempf, Georg, Luckhurst, Christopher A., Matthews, Kim, McAllister, George, Mitchell, Philip, Patel, Hiral, Rose, Mark, Saville-Stones, Elizabeth, Steinbacher, Stefan, Stott, Andrew J., Thatcher, Emma, Tierney, Jason, Urbonas, Liudvikas, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Journal Article
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Bürli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors
Luckhurst, Christopher A, Breccia, Perla, Stott, Andrew J, Aziz, Omar, Birch, Helen L, Bürli, Roland W, Hughes, Samantha J, Jarvis, Rebecca E, Lamers, Marieke, Leonard, Philip M, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Journal Article
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists
Luckhurst, Christopher A., Stein, Linda A., Furber, Mark, Webb, Nicola, Ratcliffe, Marianne J., Allenby, Gary, Botterell, Sara, Tomlinson, Wendy, Martin, Barrie, Walding, Andrew
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092
Bahl, Ash, Barton, Patrick, Bowers, Keith, Caffrey, Moya V., Denton, Rebecca, Gilmour, Peter, Hawley, Shaun, Linannen, Tero, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Riley, Robert J., Roe, Emma, Springthorpe, Brian, Stein, Linda, Webborn, Peter
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists
Luckhurst, Christopher A., Ratcliffe, Marianne, Stein, Linda, Furber, Mark, Botterell, Sara, Laughton, David, Tomlinson, Wendy, Weaver, Richard, Chohan, Kamaldeep, Walding, Andrew
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
The discovery of CCR3/H1 dual antagonists with reduced hERG risk
Bahl, Ash, Barton, Patrick, Bowers, Keith, Brough, Steven, Evans, Richard, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Rigby, Aaron, Riley, Robert J., Sanganee, Hitesh, Sisson, Adam, Springthorpe, Brian
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
Published in Bioorganic & medicinal chemistry letters (01.11.2012)
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Journal Article
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class Ha histone deacetylase inhibitor
Luckhurst, Christopher A., Aziz, Omar, Beaumont, Vahri, Burli, Roland W., Breccia, Perla, Maillard, Michel C., Haughan, Alan F., Lamers, Marieke, Leonard, Phil, Matthews, Kim L., Raphy, Gilles, Stott, Andrew J., Munoz-Sanjuan, Ignacio, Thomas, Beth, Wall, Michael, Wishart, Grant, Yates, Dawn, Dominguez, Celia
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Journal Article
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease
Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
미토콘드리아 기능장애, 암 및 섬유증의 치료에 사용하기 위한 USP30 억제제로서 1--4-메틸헥사하이드로피롤로[3,4-b]피롤-5(1H)-카보니트릴
THOMPSON PAUL WILLIAM, STOCKLEY MARTIN LEE, LUCKHURST CHRISTOPHER ANDREW, KEMP MARK IAN
Year of Publication 14.02.2023
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Year of Publication 14.02.2023
Patent
Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate
Furber, Mark, Tiden, Anna-Karin, Gardiner, Philip, Mete, Antonio, Ford, Rhonan, Millichip, Ian, Stein, Linda, Mather, Andrew, Kinchin, Elizabeth, Luckhurst, Christopher, Barber, Simon, Cage, Peter, Sanganee, Hitesh, Austin, Rupert, Chohan, Kamaldeep, Beri, Raj, Thong, Bob, Wallace, Alan, Oreffo, Victor, Hutchinson, Ray, Harper, Steve, Debreczeni, Judit, Breed, Jason, Wissler, Lisa, Edman, Karl
Published in Journal of medicinal chemistry (27.03.2014)
Published in Journal of medicinal chemistry (27.03.2014)
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Journal Article
Abstract 454: Validation of GPR35 as a novel cancer target in digestive tract cancers and discovery of potent, selective GPR35 inverse agonists
Westcott, James, Luckhurst, Christopher A., McKenzie, Grahame, Memon, Danish, Lin, Li-Chiung, Knight, Sinead, Blaikley, Elizabeth J., Pearce, Martin, Warren, Hannah R., Parker, Eleanor, Milligan, Graeme, Hughes, Stuart W., McCarthy, Tom
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article