Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J
Published in mAbs (04.05.2015)
Published in mAbs (04.05.2015)
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Reducing target binding affinity improves the therapeutic index of anti-MET antibody-drug conjugate in tumor bearing animals
Datta-Mannan, Amita, Choi, Hiuwan, Jin, Zhaoyan, Liu, Ling, Lu, Jirong, Stokell, David J, Murphy, Anthony T, Dunn, Kenneth W, Martinez, Michelle M, Feng, Yiqing
Published in PloS one (17.04.2024)
Published in PloS one (17.04.2024)
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Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
Walsh, Robin E, Lannan, Megan, Wen, Yi, Wang, Xiaoli, Moreland, Christopher A, Willency, Jill, Knierman, Michael D, Spindler, Laura, Liu, Ling, Zeng, Wei, Rocha, Guilherme V, Obungu, Victor, Lu, Jirong, Kaliyaperumal, Arunan, Ferrante, Andrea, Siegel, Robert, Malherbe, Laurent P
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure
Chow, Chi-Kin, Allan, Barrett W, Chai, Qing, Atwell, Shane, Lu, Jirong
Published in Molecular pharmaceutics (07.03.2016)
Published in Molecular pharmaceutics (07.03.2016)
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Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies
Datta-Mannan, Amita, Estwick, Selina, Zhou, Chen, Choi, Hiuwan, Douglass, Nicole E, Witcher, Derrick R, Lu, Jirong, Beidler, Catherine, Millican, Rohn
Published in mAbs (01.01.2020)
Published in mAbs (01.01.2020)
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Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages
Chen, Qi, Vieth, Michal, Timm, David E, Humblet, Christine, Schneidman-Duhovny, Dina, Chemmama, Ilan E, Sali, Andrej, Zeng, Wei, Lu, Jirong, Liu, Ling
Published in PloS one (13.04.2017)
Published in PloS one (13.04.2017)
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FcRn affinity-pharmacokinetic relationship of five human IgG4 antibodies engineered for improved in vitro FcRn binding properties in cynomolgus monkeys
Datta-Mannan, Amita, Chow, Chi-Kin, Dickinson, Craig, Driver, David, Lu, Jirong, Witcher, Derrick R, Wroblewski, Victor J
Published in Drug metabolism and disposition (01.08.2012)
Published in Drug metabolism and disposition (01.08.2012)
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Canadian Anatomic Kidney Score: Quantitative Macroscopic Assessment of Donor Kidney Quality for Transplantation
Matti, Danny, Offerni, Juliano, Roshanov, Pavel S, Lu, Jirong, Guo, Yanbo, Lebedeva, Victoria, Ai Li, Erica, Abed, Haider, Luke, William, Sener, Alp, Luke, Patrick P
Published in Transplantation direct (01.04.2024)
Published in Transplantation direct (01.04.2024)
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Application of clinico-radiologic-pathologic diagnosis of diffuse parenchymal lung diseases in children in China
Xu, Dan, Chen, Zhimin, Chen, Huizhong, Huang, Rongyan, Zhao, Shunying, Liu, Xiuyun, Zhou, Chunju, Peng, Yun, Yuan, Xinyu, Zou, Jizhen, Zhang, Hailing, Zhao, Deyu, Liu, Enmei, Zheng, Yuejie, Zhong, Lili, Lu, Min, Lu, Jirong, Nong, Guangmin
Published in PloS one (08.01.2015)
Published in PloS one (08.01.2015)
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Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase
Wang, Q May, Hockman, Michelle A, Staschke, Kirk, Johnson, Robert B, Case, Katharine A, Lu, Jirong, Parsons, Steve, Zhang, Faming, Rathnachalam, Radhakrishnan, Kirkegaard, Karla, Colacino, Joseph M
Published in Journal of Virology (01.04.2002)
Published in Journal of Virology (01.04.2002)
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In Vivo Deamidation Characterization of Monoclonal Antibody by LC/MS/MS
Huang, Lihua, Lu, Jirong, Wroblewski, Victor J, Beals, John M, Riggin, Ralph M
Published in Analytical chemistry (Washington) (01.03.2005)
Published in Analytical chemistry (Washington) (01.03.2005)
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