Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity
Gaohua, Lu, Miao, Xiusheng, Dou, Liu
Published in Expert opinion on drug metabolism & toxicology (02.09.2021)
Published in Expert opinion on drug metabolism & toxicology (02.09.2021)
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Journal Article
The Interplay of Permeability, Metabolism, Transporters, and Dosing in Determining the Dynamics of the Tissue/Plasma Partition Coefficient and Volume of Distribution—A Theoretical Investigation Using Permeability-Limited, Physiologically Based Pharmacokinetic Modeling
Gaohua, Lu, Zhang, Mian, Sychterz, Caroline, Chang, Ming, Schmidt, Brian James
Published in International journal of molecular sciences (01.11.2023)
Published in International journal of molecular sciences (01.11.2023)
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Journal Article
Drug-Drug Interaction Potential of Mavacamten with Oral Contraceptives: Results from a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model
Chiang, Manting, Sychterz, Caroline, Gaohua, Lu, Perera, Vidya, Gretler, Daniel D, Florea, Victoria, Merali, Samira
Published in Journal of clinical pharmacology (01.11.2023)
Published in Journal of clinical pharmacology (01.11.2023)
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Journal Article
A pregnancy physiologically based pharmacokinetic (p‐PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4
Gaohua, Lu, Abduljalil, Khaled, Jamei, Masoud, Johnson, Trevor N., Rostami‐Hodjegan, Amin
Published in British journal of clinical pharmacology (01.11.2012)
Published in British journal of clinical pharmacology (01.11.2012)
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Journal Article
Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions
Wu, Fang, Gaohua, Lu, Zhao, Ping, Jamei, Masoud, Huang, Shiew-Mei, Bashaw, Edward D., Lee, Sue-Chih
Published in Pharmaceutical research (01.08.2014)
Published in Pharmaceutical research (01.08.2014)
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Journal Article
Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data
Gaohua, Lu, Neuhoff, Sibylle, Johnson, Trevor N., Rostami-Hodjegan, Amin, Jamei, Masoud
Published in Drug metabolism and pharmacokinetics (01.06.2016)
Published in Drug metabolism and pharmacokinetics (01.06.2016)
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Journal Article
A perspective on the current use of the phase distribution model for predicting milk‐to‐plasma drug concentration ratio
Zhang, Mian, Sychterz, Caroline, Chang, Ming, Huang, Lu, Schmidt, Brian J., Gaohua, Lu
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
Published in CPT: pharmacometrics and systems pharmacology (01.12.2022)
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Journal Article
Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21
Sychterz, Caroline, Gardner, Iain, Chiang, Manting, Rachumallu, Ramakrishna, Neuhoff, Sibylle, Perera, Vidya, Merali, Samira, Schmidt, Brian J, Gaohua, Lu
Published in Metabolites (20.10.2022)
Published in Metabolites (20.10.2022)
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Journal Article
An integrated model of thermodynamic–hemodynamic–pharmacokinetic system and its application on decoupling control of intracranial temperature and pressure in brain hypothermia treatment
Gaohua, Lu, Maekawa, Tsuyoshi, Kimura, Hidenori
Published in Journal of theoretical biology (07.09.2006)
Published in Journal of theoretical biology (07.09.2006)
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Journal Article
Advancements in physiologically based pharmacokinetic modeling for fedratinib: updating dose guidance in the presence of a dual inhibitor of CYP3A4 and CYP2C19
Chang, Ming, Chen, Yizhe, Ogasawara, Ken, Schmidt, Brian James, Gaohua, Lu
Published in Cancer chemotherapy and pharmacology (01.10.2024)
Published in Cancer chemotherapy and pharmacology (01.10.2024)
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Journal Article
Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses
Zhang, Zufei, Imperial, Marjorie Z, Patilea-Vrana, Gabriela I, Wedagedera, Janak, Gaohua, Lu, Unadkat, Jashvant D
Published in Drug metabolism and disposition (01.08.2017)
Published in Drug metabolism and disposition (01.08.2017)
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Journal Article
Physiologically Based Pharmacokinetic Modeling and Simulation of Mavacamten Exposure with Drug–Drug Interactions from CYP Inducers and Inhibitors by CYP2C19 Phenotype
Chiang, Manting, Sychterz, Caroline, Perera, Vidya, Merali, Samira, Palmisano, Maria, Templeton, Ian E., Gaohua, Lu
Published in Clinical pharmacology and therapeutics (01.10.2023)
Published in Clinical pharmacology and therapeutics (01.10.2023)
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Journal Article
Decoupling Control of Intracranial Temperature and Pressure for Brain Hypothermia Treatment
Lu Gaohua, Kimura, H.
Published in 2006 IEEE International Conference on Systems, Man and Cybernetics (01.10.2006)
Published in 2006 IEEE International Conference on Systems, Man and Cybernetics (01.10.2006)
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Conference Proceeding
A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk
Sychterz, Caroline, Shen, Hong, Zhang, Yueping, Sinz, Michael, Rostami-Hodjegan, Amin, Schmidt, Brian J, Gaohua, Lu, Galetin, Aleksandra
Published in CPT: pharmacometrics and systems pharmacology (18.09.2024)
Published in CPT: pharmacometrics and systems pharmacology (18.09.2024)
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Journal Article