Identification and characterization of Cardiac Glycosides as senolytic compounds
Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P, Fernández-Marcos, Pablo J, García-Caballero, Tomás, Del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I, Domínguez, Eduardo, Collado, Manuel
Published in Nature communications (21.10.2019)
Published in Nature communications (21.10.2019)
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A Positive Allosteric Modulator of the Serotonin 5‑HT2C Receptor for Obesity
García-Cárceles, Javier, Decara, Juan M., Vázquez-Villa, Henar, Rodríguez, Ramón, Codesido, Eva, Cruces, Jacobo, Brea, José, Loza, María I., Alén, Francisco, Botta, Joaquin, McCormick, Peter J., Ballesteros, Juan A., Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
Areias, Filipe, Correia, Carla, Rocha, Ashly, Teixeira, Sofia, Castro, Marián, Brea, Jose, Hu, Huabin, Carlsson, Jens, Loza, Maria I, Proença, M. Fernanda, Carvalho, M. Alice
Published in Molecules (Basel, Switzerland) (01.06.2024)
Published in Molecules (Basel, Switzerland) (01.06.2024)
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Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin
Ruiz-DeDiego, Irene, Fasano, Stefania, Solís, Oscar, Garcia-Montes, José-Rubén, Brea, José, Loza, María I, Brambilla, Riccardo, Moratalla, Rosario
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model
Redondo, Miriam, Zarruk, Juan G., Ceballos, Placido, Pérez, Daniel I., Pérez, Concepción, Perez-Castillo, Ana, Moro, María A., Brea, José, Val, Cristina, Cadavid, María I., Loza, María I., Campillo, Nuria E., Martínez, Ana, Gil, Carmen
Published in European journal of medicinal chemistry (2012)
Published in European journal of medicinal chemistry (2012)
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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries
Brea, Jose, Varela, Maria J., Daudey, Geert A., Loza, Maria I.
Published in SLAS discovery (01.04.2024)
Published in SLAS discovery (01.04.2024)
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A 2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Tay, Apple Hui Min, Prieto-Díaz, Rubén, Neo, Shiyong, Tong, Le, Chen, Xinsong, Carannante, Valentina, Önfelt, Björn, Hartman, Johan, Haglund, Felix, Majellaro, Maria, Azuaje, Jhonny, Garcia-Mera, Xerardo, Brea, Jose M, Loza, Maria I, Jespers, Willem, Gutierrez-de-Teran, Hugo, Sotelo, Eddy, Lundqvist, Andreas
Published in Journal for immunotherapy of cancer (01.05.2022)
Published in Journal for immunotherapy of cancer (01.05.2022)
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Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M
Aragó, Marc, Moreno-Felici, Juan, Abás, Sonia, Rodríguez-Arévalo, Sergio, Hyroššová, Petra, Figueras, Agnes, Viñals, Francesc, Pérez, Belén, Loza, Maria I., Brea, Jose, Latorre, Pedro, Carrodeguas, Jose A., García-Rovés, Pablo M., Galdeano, Carlos, Ginex, Tiziana, Luque, Francisco J., Escolano, Carmen, Perales, Jose C.
Published in Biomedicine & pharmacotherapy (01.01.2020)
Published in Biomedicine & pharmacotherapy (01.01.2020)
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Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders
Caruncho, Hector J, Kalynchuk, Lisa E, Loza, Maria I, Olivares, Jose M
Published in Frontiers in pharmacology (17.05.2019)
Published in Frontiers in pharmacology (17.05.2019)
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Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands
ORTEGA, Raquel, RAVINA, Enrique, MASAGUER, Christian F, AREIAS, Filipe, BREA, José, LOZA, Maria I, LOPEZ, Laura, SELENT, Jana, PASTOR, Manuel, SANZ, Ferran
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Structure‐Based Virtual Screening for Dopamine D 2 Receptor Ligands as Potential Antipsychotics
Kaczor, Agnieszka A., Silva, Andrea G., Loza, María I., Kolb, Peter, Castro, Marián, Poso, Antti
Published in ChemMedChem (05.04.2016)
Published in ChemMedChem (05.04.2016)
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Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands
Barceló, María, Raviña, Enrique, Varela, María J., Brea, José, Loza, María I., Masaguer, Christian F.
Published in MedChemComm (01.12.2011)
Published in MedChemComm (01.12.2011)
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5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
Toro-Sazo, Miguel, Brea, José, Loza, María I, Cimadevila, Marta, Cassels, Bruce K
Published in PloS one (01.01.2019)
Published in PloS one (01.01.2019)
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Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs
Kondej, Magda, Wróbel, Tomasz M., Silva, Andrea G., Stępnicki, Piotr, Koszła, Oliwia, Kędzierska, Ewa, Bartyzel, Agata, Biała, Grażyna, Matosiuk, Dariusz, Loza, Maria I., Castro, Marián, Kaczor, Agnieszka A.
Published in European journal of medicinal chemistry (15.10.2019)
Published in European journal of medicinal chemistry (15.10.2019)
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Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2‑Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Carbajales, Carlos, Azuaje, Jhonny, Oliveira, Ana, Loza, María I, Brea, José, Cadavid, María I, Masaguer, Christian F, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Exploring Biginelli-based scaffolds as A 2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Prieto-Díaz, Rubén, Fojo-Carballo, Hugo, Majellaro, Maria, Tandarić, Tana, Azuaje, Jhonny, Brea, José, Loza, María I, Barbazán, Jorge, Salort, Glòria, Chotalia, Meera, Rodríguez-Pampín, Iván, Mallo-Abreu, Ana, Rita Paleo, M, García-Mera, Xerardo, Ciruela, Francisco, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Biomedicine & pharmacotherapy (01.04.2024)
Published in Biomedicine & pharmacotherapy (01.04.2024)
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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Nogueira-Recalde, Uxía, Lorenzo-Gómez, Irene, Blanco, Francisco J., Loza, María I., Grassi, Diego, Shirinsky, Valery, Shirinsky, Ivan, Lotz, Martin, Robbins, Paul D., Domínguez, Eduardo, Caramés, Beatriz
Published in EBioMedicine (01.07.2019)
Published in EBioMedicine (01.07.2019)
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2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships
Areias, Filipe, Correia, Carla, Rocha, Ashly, Brea, José, Castro, Marián, Loza, Maria I., Proença, M. Fernanda, Carvalho, M. Alice
Published in Bioorganic & medicinal chemistry (15.08.2019)
Published in Bioorganic & medicinal chemistry (15.08.2019)
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A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade
Izquierdo, Irene, Barrachina, María N, Hermida-Nogueira, Lidia, Casas, Vanessa, Morán, Luis A, Lacerenza, Serena, Pinto-Llorente, Roberto, Eble, Johannes A, de Los Ríos, Vivian, Domínguez, Eduardo, Loza, María I, Casal, José Ignacio, Carrascal, Montserrat, Abián, Joaquín, García, Angel
Published in Thrombosis and haemostasis (01.02.2020)
Published in Thrombosis and haemostasis (01.02.2020)
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Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug
Pflüger, Pricila, Pereira, Patrícia, Loza, María I., Brea, José, Viña, Dolores, Kumar, Amit, Fontenla, José A.
Published in European journal of pharmacology (05.09.2021)
Published in European journal of pharmacology (05.09.2021)
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