Identification and characterization of Cardiac Glycosides as senolytic compounds
Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P, Fernández-Marcos, Pablo J, García-Caballero, Tomás, Del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I, Domínguez, Eduardo, Collado, Manuel
Published in Nature communications (21.10.2019)
Published in Nature communications (21.10.2019)
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5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines
Toro-Sazo, Miguel, Brea, José, Loza, María I, Cimadevila, Marta, Cassels, Bruce K
Published in PloS one (01.01.2019)
Published in PloS one (01.01.2019)
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A Positive Allosteric Modulator of the Serotonin 5‑HT2C Receptor for Obesity
García-Cárceles, Javier, Decara, Juan M., Vázquez-Villa, Henar, Rodríguez, Ramón, Codesido, Eva, Cruces, Jacobo, Brea, José, Loza, María I., Alén, Francisco, Botta, Joaquin, McCormick, Peter J., Ballesteros, Juan A., Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L.
Published in Journal of medicinal chemistry (14.12.2017)
Published in Journal of medicinal chemistry (14.12.2017)
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2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
Areias, Filipe, Correia, Carla, Rocha, Ashly, Teixeira, Sofia, Castro, Marián, Brea, Jose, Hu, Huabin, Carlsson, Jens, Loza, Maria I, Proença, M. Fernanda, Carvalho, M. Alice
Published in Molecules (Basel, Switzerland) (01.06.2024)
Published in Molecules (Basel, Switzerland) (01.06.2024)
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A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade
Izquierdo, Irene, Barrachina, María N, Hermida-Nogueira, Lidia, Casas, Vanessa, Morán, Luis A, Lacerenza, Serena, Pinto-Llorente, Roberto, Eble, Johannes A, de Los Ríos, Vivian, Domínguez, Eduardo, Loza, María I, Casal, José Ignacio, Carrascal, Montserrat, Abián, Joaquín, García, Angel
Published in Thrombosis and haemostasis (01.02.2020)
Published in Thrombosis and haemostasis (01.02.2020)
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Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
Prieto-Díaz, Rubén, Fojo-Carballo, Hugo, Majellaro, Maria, Tandarić, Tana, Azuaje, Jhonny, Brea, José, Loza, María I., Barbazán, Jorge, Salort, Glòria, Chotalia, Meera, Rodríguez-Pampín, Iván, Mallo-Abreu, Ana, Rita Paleo, M., García-Mera, Xerardo, Ciruela, Francisco, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Biomedicine & pharmacotherapy (01.04.2024)
Published in Biomedicine & pharmacotherapy (01.04.2024)
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Journal Article
Mature Andean forests as globally important carbon sinks and future carbon refuges
Duque, Alvaro, Peña, Miguel A, Cuesta, Francisco, González-Caro, Sebastián, Kennedy, Peter, Phillips, Oliver L, Calderón-Loor, Marco, Blundo, Cecilia, Carilla, Julieta, Cayola, Leslie, Farfán-Ríos, William, Fuentes, Alfredo, Grau, Ricardo, Homeier, Jürgen, Loza-Rivera, María I, Malhi, Yadvinder, Malizia, Agustina, Malizia, Lucio, Martínez-Villa, Johanna A, Myers, Jonathan A, Osinaga-Acosta, Oriana, Peralvo, Manuel, Pinto, Esteban, Saatchi, Sassan, Silman, Miles, Tello, J Sebastián, Terán-Valdez, Andrea, Feeley, Kenneth J
Published in Nature communications (09.04.2021)
Published in Nature communications (09.04.2021)
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Journal Article
Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2‑Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Carbajales, Carlos, Azuaje, Jhonny, Oliveira, Ana, Loza, María I, Brea, José, Cadavid, María I, Masaguer, Christian F, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Journal of medicinal chemistry (27.04.2017)
Published in Journal of medicinal chemistry (27.04.2017)
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Journal Article
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Nogueira-Recalde, Uxía, Lorenzo-Gómez, Irene, Blanco, Francisco J., Loza, María I., Grassi, Diego, Shirinsky, Valery, Shirinsky, Ivan, Lotz, Martin, Robbins, Paul D., Domínguez, Eduardo, Caramés, Beatriz
Published in EBioMedicine (01.07.2019)
Published in EBioMedicine (01.07.2019)
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Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug
Pflüger, Pricila, Pereira, Patrícia, Loza, María I., Brea, José, Viña, Dolores, Kumar, Amit, Fontenla, José A.
Published in European journal of pharmacology (05.09.2021)
Published in European journal of pharmacology (05.09.2021)
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The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential
Barrachina, María N, Izquierdo, Irene, Hermida-Nogueira, Lidia, Morán, Luis A, Pérez, Amparo, Arroyo, Ana B, García-Barberá, Nuria, González-Conejero, Rocío, Troitiño, Sara, Eble, Johannes A, Rivera, José, Martínez, Constantino, Loza, María I, Domínguez, Eduardo, García, Ángel
Published in International journal of molecular sciences (24.03.2021)
Published in International journal of molecular sciences (24.03.2021)
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Exploring the Effect of Halogenation in a Series of Potent and Selective A 2B Adenosine Receptor Antagonists
Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I, Brea, José, Fernández-Dueñas, Víctor, Paleo, M Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C, Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Journal Article
Exploring the Effect of Halogenation in a Series of Potent and Selective A2B Adenosine Receptor Antagonists
Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
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Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder
Lacivita, Enza, Niso, Mauro, Mastromarino, Margherita, Garcia Silva, Andrea, Resch, Cibell, Zeug, Andre, Loza, María I, Castro, Marián, Ponimaskin, Evgeni, Leopoldo, Marcello
Published in ACS chemical neuroscience (21.04.2021)
Published in ACS chemical neuroscience (21.04.2021)
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Discovery of V‑0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide‑1 Receptor toward Oral Treatment for “Diabesity”
Decara, Juan M, Vázquez-Villa, Henar, Brea, José, Alonso, Mónica, Srivastava, Raj Kamal, Orio, Laura, Alén, Francisco, Suárez, Juan, Baixeras, Elena, García-Cárceles, Javier, Escobar-Peña, Andrea, Lutz, Beat, Rodríguez, Ramón, Codesido, Eva, Garcia-Ladona, F. Javier, Bennett, Teresa A, Ballesteros, Juan A, Cruces, Jacobo, Loza, María I, Benhamú, Bellinda, Rodríguez de Fonseca, Fernando, López-Rodríguez, María L
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes
Zhubi, A, Veldic, M, Puri, N.V, Kadriu, B, Caruncho, H, Loza, I, Sershen, H, Lajtha, A, Smith, R.C, Guidotti, A, Davis, J.M, Costa, E
Published in Schizophrenia research (01.06.2009)
Published in Schizophrenia research (01.06.2009)
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Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin
Ruiz-DeDiego, Irene, Fasano, Stefania, Solís, Oscar, Garcia-Montes, José-Rubén, Brea, José, Loza, María I, Brambilla, Riccardo, Moratalla, Rosario
Published in Scientific reports (18.10.2018)
Published in Scientific reports (18.10.2018)
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High-throughput nephelometry methodology for qualitative determination of aqueous solubility of chemical libraries
Brea, Jose, Varela, Maria J., Daudey, Geert A., Loza, Maria I.
Published in SLAS discovery (01.04.2024)
Published in SLAS discovery (01.04.2024)
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