Novel antibody–antibiotic conjugate eliminates intracellular S. aureus
Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer, Darwish, Martine, Lee, Byoung-Chul, Hernandez, Hilda, Loyet, Kelly M., Lupardus, Patrick, Fong, Rina, Yan, Donghong, Chalouni, Cecile, Luis, Elizabeth, Khalfin, Yana, Plise, Emile, Cheong, Jonathan, Lyssikatos, Joseph P., Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S., Flygare, John A., Wah Tan, Man, Brown, Eric J., Mariathasan, Sanjeev
Published in Nature (London) (19.11.2015)
Published in Nature (London) (19.11.2015)
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Dramatic activation of an antibody by a single amino acid change in framework
Liang, Wei-Ching, Yin, Jianping, Lupardus, Patrick, Zhang, Jianhuan, Loyet, Kelly M., Sudhamsu, Jawahar, Wu, Yan
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Published in Scientific reports (16.11.2021)
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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.
Published in Nature communications (22.12.2020)
Published in Nature communications (22.12.2020)
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Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye
Shatz, Whitney, Hass, Philip E, Peer, Nikhil, Paluch, Maciej T, Blanchette, Craig, Han, Guanghui, Sandoval, Wendy, Morando, Ashley, Loyet, Kelly M, Bantseev, Vladimir, Booler, Helen, Crowell, Susan, Kamath, Amrita, Scheer, Justin M, Kelley, Robert F
Published in PloS one (28.06.2019)
Published in PloS one (28.06.2019)
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Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins
Laing, Steven T, Tassew, Nardos, Tesar, Devin, Wang, Yue, Crowell, Susan R, Gray, Julia, Kwong, Mandy, Loyet, Kelly M, Andaya, Roxanne, Kusi, Aija, Kelley, Robert F
Published in Toxicologic pathology (01.04.2021)
Published in Toxicologic pathology (01.04.2021)
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Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate
Kajihara, Kimberly K, Pantua, Homer, Hernandez-Barry, Hilda, Hazen, Meredith, Deshmukh, Kiran, Chiang, Nancy, Ohri, Rachana, Castellanos, Erick R, Martin, Lynn, Matsumoto, Marissa L, Payandeh, Jian, Storek, Kelly M, Schneider, Kellen, Smith, Peter A, Koehler, Michael F T, Tsai, Siao Ping, Vandlen, Richard, Loyet, Kelly M, Nakamura, Gerald, Pillow, Thomas, Seshasayee, Dhaya, Kapadia, Sharookh B, Hazenbos, Wouter L W
Published in mBio (29.06.2021)
Published in mBio (29.06.2021)
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Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration
Loyet, Kelly M, Good, Jeremy, Davancaze, Teresa, Sturgeon, Lizette, Wang, Xiangdan, Yang, Jihong, Le, Kha N, Wong, Maureen, Hass, Philip E, van Lookeren Campagne, Menno, Haughney, Peter C, Morimoto, Alyssa, Damico-Beyer, Lisa A, DeForge, Laura E
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
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Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development
Mai, Elaine, Chan, Joyce, Goon, Levina, Ego, Braeden K, Bevers, Jack, Wong, Tiffany, Wong, Manda, Corpuz, Racquel, Xi, Hongkang, Wu, Jia, Schneider, Kellen, Seshasayee, Dhaya, Grimbaldeston, Michele, Nakamura, Gerald, Indjeian, Vahan B, van Lookeren Campagne, Menno, Loyet, Kelly M, Comps-Agrar, Laetitia
Published in Journal of translational medicine (20.12.2021)
Published in Journal of translational medicine (20.12.2021)
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A Coreceptor Interaction between the CD28 and TNF Receptor Family Members B and T Lymphocyte Attenuator and Herpesvirus Entry Mediator
Gonzalez, Lino C., Loyet, Kelly M., Calemine-Fenaux, Jill, Chauhan, Vandana, Wranik, Bernd, Ouyang, Wenjun, Eaton, Dan L., Scheller, Richard H.
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2005)
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Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement
Katschke, Kenneth J., Stawicki, Scott, Yin, Jianping, Steffek, Micah, Xi, Hongkang, Sturgeon, Lizette, Hass, Philip E., Loyet, Kelly M., DeForge, Laura, Wu, Yan, van Lookeren Campagne, Menno, Wiesmann, Christian
Published in The Journal of biological chemistry (17.04.2009)
Published in The Journal of biological chemistry (17.04.2009)
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Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors
Goodrich, Andrew C., LeClair, Norbert P., Shillova, Nita, Morton, William D., Wittwer, Arthur J., Loyet, Kelly M., Hannoush, Rami N.
Published in The Journal of biological chemistry (01.07.2024)
Published in The Journal of biological chemistry (01.07.2024)
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Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases
Stefanich, Eric G., Rae, Julie, Sukumaran, Siddharth, Lutman, Jeff, Lekkerkerker, Annemarie, Ouyang, Wenjun, Wang, Xiaoting, Lee, Donna, Danilenko, Dimitry M., Diehl, Lauri, Loyet, Kelly M., Herman, Ann
Published in Biochemical pharmacology (01.06.2018)
Published in Biochemical pharmacology (01.06.2018)
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CAPS Activity in Priming Vesicle Exocytosis Requires CK2 Phosphorylation
Nojiri, Mari, Loyet, Kelly M., Klenchin, Vadim A., Kabachinski, Gregory, Martin, Thomas F.J.
Published in The Journal of biological chemistry (10.07.2009)
Published in The Journal of biological chemistry (10.07.2009)
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Membrane Association Domains in Ca2+-dependent Activator Protein for Secretion Mediate Plasma Membrane and Dense-core Vesicle Binding Required for Ca2+-dependent Exocytosis
Grishanin, Ruslan N, Klenchin, Vadim A, Loyet, Kelly M, Kowalchyk, Judith A, Ann, Kyoungsook, Martin, Thomas F J
Published in The Journal of biological chemistry (14.06.2002)
Published in The Journal of biological chemistry (14.06.2002)
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Hyaluronic Acid–Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics
Famili, Amin, Crowell, Susan R, Loyet, Kelly M, Mandikian, Danielle, Boswell, C. Andrew, Cain, David, Chan, Joyce, Comps-Agrar, Laetitia, Kamath, Amrita, Rajagopal, Karthikan
Published in Bioconjugate chemistry (20.11.2019)
Published in Bioconjugate chemistry (20.11.2019)
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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
Zacharias, Neelie, Podust, Vladimir N, Kajihara, Kimberly K, Leipold, Douglas, Del Rosario, Geoffrey, Thayer, Desiree, Dong, Emily, Paluch, Maciej, Fischer, David, Zheng, Kai, Lei, Corinna, He, Jintang, Ng, Carl, Su, Dian, Liu, Luna, Masih, Shabkhaiz, Sawyer, William, Tinianow, Jeff, Marik, Jan, Yip, Victor, Li, Guangmin, Chuh, Josefa, Morisaki, J Hiroshi, Park, Summer, Zheng, Bing, Hernandez-Barry, Hilda, Loyet, Kelly M, Xu, Min, Kozak, Katherine R, Phillips, Gail Lewis, Shen, Ben-Quan, Wu, Cong, Xu, Keyang, Yu, Shang-Fan, Kamath, Amrita, Rowntree, Rebecca K, Reilly, Dorothea, Pillow, Thomas, Polson, Andrew, Schellenberger, Volker, Hazenbos, Wouter L W, Sadowsky, Jack
Published in Chemical science (Cambridge) (16.03.2022)
Published in Chemical science (Cambridge) (16.03.2022)
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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis
Chavarria-Smith, Joseph, Chiu, Cecilia P C, Jackman, Janet K, Yin, Jianping, Zhang, Juan, Hackney, Jason A, Lin, Wei-Yu, Tyagi, Tulika, Sun, Yonglian, Tao, Janet, Dunlap, Debra, Morton, William D, Ghodge, Swapnil V, Maun, Henry R, Li, Hong, Hernandez-Barry, Hilda, Loyet, Kelly M, Chen, Emily, Liu, John, Tam, Christine, Yaspan, Brian L, Cai, Hao, Balazs, Mercedesz, Arron, Joseph R, Li, Jing, Wittwer, Arthur J, Pappu, Rajita, Austin, Cary D, Lee, Wyne P, Lazarus, Robert A, Sudhamsu, Jawahar, Koerber, James T, Yi, Tangsheng
Published in Science translational medicine (14.12.2022)
Published in Science translational medicine (14.12.2022)
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Fab-Nanolipoprotein Conjugate Causes Vitreous Opacity and Cataracts Following a Single Intravitreal Administration in New Zealand White Rabbits
Tassew, Nardos G, Laing, Steven T, Shatz, Whitney, Crowell, Susan R, Loyet, Kelly M, Schuetz, Chris, Blanchette, Craig
Published in Toxicologic pathology (01.04.2021)
Published in Toxicologic pathology (01.04.2021)
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Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules
Crowell, Susan R, Wang, Kathryn, Famili, Amin, Shatz, Whitney, Loyet, Kelly M, Chang, Vincent, Liu, Yanqiu, Prabhu, Saileta, Kamath, Amrita V, Kelley, Robert F
Published in Translational vision science & technology (01.11.2019)
Published in Translational vision science & technology (01.11.2019)
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Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration
Loyet, Kelly M, Deforge, Laura E, Katschke, Jr, Kenneth J, Diehl, Lauri, Graham, Robert R, Pao, Lily, Sturgeon, Lizette, Lewin-Koh, Sock-Cheng, Hollyfield, Joe G, van Lookeren Campagne, Menno
Published in Investigative ophthalmology & visual science (25.09.2012)
Published in Investigative ophthalmology & visual science (25.09.2012)
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