Robust Antibody–Antigen Complexes Prediction Generated by Combining Sequence Analyses, Mutagenesis, In Vitro Evolution, X-ray Crystallography and In Silico Docking
Loyau, Jérémy, Didelot, Gérard, Malinge, Pauline, Ravn, Ulla, Magistrelli, Giovanni, Depoisier, Jean-François, Pontini, Guillemette, Poitevin, Yves, Kosco-Vilbois, Marie, Fischer, Nicolas, Thore, Stéphane, Rousseau, François
Published in Journal of molecular biology (14.08.2015)
Published in Journal of molecular biology (14.08.2015)
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Journal Article
Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to Fcγ receptors: Fc-mediated avidity enhances the potency of an anti-TLR4 antibody
Loyau, Jérémy, Malinge, Pauline, Daubeuf, Bruno, Shang, Limin, Elson, Greg, Kosco-Vilbois, Marie, Fischer, Nicolas, Rousseau, François
Published in mAbs (02.11.2014)
Published in mAbs (02.11.2014)
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Journal Article
ISB 2001, a First-in-Class Trispecific BCMA and CD38 T Cell Engager Designed to Overcome Mechanisms of Escape from Treatments for Multiple Myeloma By Targeting Two Antigens
Pihlgren, Maria, Hall, Olivia, Carretero, Laura, Estoppey, Carole, Drake, Adam, Pais, Daniela, Loyau, Jeremy, Berret, Jeremy, Gruber, Isabelle, Suere, Perrine, Schnorhk, Vincent, Nallet, Emilie, Pouleau, Blandine, Chimen, Myriam, Macoin, Julie, Stainnack, Elodie, Monney, Thierry, Delachat, Aurore, Dreyfus, Cyrille, Matthes, Thomas, Konto, Cyril, Dyson, Michael, Blein, Stanislas, Mbow, Lamine, Wood, Rebecca, Srivastava, Ankita, Zhukovsky, Eugene, Perro, Mario
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
ISB 1442, a First-in-Class CD38 and CD47 Bispecific Antibody Innate Cell Modulator for the Treatment of Relapsed Refractory Multiple Myeloma
Stefano, Sammicheli, Grandclement, Camille, Dehilly, Elie, Panagopoulou, Maria, Martini, Evangelia, Castillo, Rosa, Suere, Perrine, Pouleau, Blandine, Estoppey, Carole, Frei, Julia, Loyau, Jeremy, Monney, Thierry, Wood, Rebecca, Croset, Amelie, Rubod, Alain, Gudi, Girish, Udupa, Venkatesha, Gn, Sunitha, Menon, Vinu, Rasmussen, Daniel, Olsen, Jeppe Koch, Giovannini, Roberto, Chakrapani, Aravind, Blein, Stanislas, Doucey, Marie-Agnes, Drake, Adam, Riva, Alessandro, Konto, Cyril, Perro, Mario, Mbow, Lamine
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Abstract 2970: Overcoming mechanisms of escape from treatments for multiple myeloma with ISB 2001, a potential first-in-class trispecific BCMA and CD38 targeted T cell engager
Pihlgren, Maria, Carretero, Laura, Berret, Jeremy, Hall, Olivia, Estoppey, Carole, Drake, Adam, Pais, Daniela, Macoin, Julie, Chimen, Myriam, Suere, Perrine, Nallet, Emily, Pouleau, Blandine, Stainnack, Elodie, Loyau, Jeremy, Monney, Thierry, Delachat, Aurore, Dreyfus, Cyrille, Blein, Stan, Kaya, Zeynep, Matthes, Thomas, Croasdale-wood, Rebecca, Edwards, James, Edwards, Claire, Mbow, Lamine, Dyson, Michael, Konto, Cyril, Srivastava, Ankita, Zhukovshy, Eugene, Perro, Mario
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
CD3/BCMA/CD38 Trispecific Antibodies
MACOIN, Julie, CHIMEN, Myriam, LOYAU, Jérémy, MONNEY, Thierry, DREYFUS, Cyrille, PIHLGREN BOSCH, Maria, CROASDALE-WOOD, Rebecca, PERRO, Mario, SRIVASTAVA, Ankita, DYSON, Michael, CARRETERO IGLESIA, Laura, PAIS, Daniela, ESTOPPEY, Carole, HALL, Olivia, DRAKE, Adam
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
Patent
ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells
Carretero-Iglesia, Laura, Hall, Olivia J., Berret, Jérémy, Pais, Daniela, Estoppey, Carole, Chimen, Myriam, Monney, Thierry, Loyau, Jeremy, Dreyfus, Cyrille, Macoin, Julie, Perez, Cynthia, Menon, Vinu, Gruber, Isabelle, Laurendon, Amélie, Caro, Lydia N., Gudi, Girish S., Matsuura, Tomomi, van der Graaf, Piet H., Blein, Stanislas, Mbow, M. Lamine, Croasdale-Wood, Rebecca, Srivastava, Ankita, Dyson, Michael R., Matthes, Thomas, Kaya, Zeynep, Edwards, Claire M., Edwards, James R., Maiga, Sophie, Pellat-Deceunynck, Catherine, Touzeau, Cyrille, Moreau, Philippe, Konto, Cyril, Drake, Adam, Zhukovsky, Eugene A., Perro, Mario, Pihlgren, Maria
Published in Nature cancer (11.09.2024)
Published in Nature cancer (11.09.2024)
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Journal Article
CD3/BCMA/CD38 Trispecific Antibodies
MACOIN, Julie, CHIMEN, Myriam, LOYAU, Jérémy, MONNEY, Thierry, DREYFUS, Cyrille, PIHLGREN BOSCH, Maria, CROASDALE-WOOD, Rebecca, PERRO, Mario, SRIVASTAVA, Ankita, DYSON, Michael, CARRETERO IGLESIA, Laura, PAIS, Daniela, ESTOPPEY, Carole, HALL, Olivia, DRAKE, Adam
Year of Publication 25.04.2024
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Year of Publication 25.04.2024
Patent
Abstract 2903: ISB 1442, a first-in-class CD38 and CD47 bispecific antibody innate cell modulator for the treatment of CD38+ malignancies
Sammicheli, Stefano, Grandclement, Camille, Dheilly, Elie, Panagopoulou, Maria, Martini, Evangelia, Suere, Perrine, Pouleau, Blandine, Estoppey, Carole, Frei, Julia, Loyau, Jeremy, Monney, Thierry, Drake, Adam, Rubod, Alain, Doucey, Marie Agnes, Menon, Vinu, Udupa, Venkatesha, GN, Sunitha, Rasmussen, Daniel, Olsen, Jeppe Koch, Gionannini, Roberto, Gudi, Girish, Srivastava, Ankita, Konto, Cyril, Perro, Mario
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
CD3/BCMA/CD38 TRISPECIFIC ANTIBODIES
MACOIN, Julie, CHIMEN, Myriam, LOYAU, Jérémy, MONNEY, Thierry, DREYFUS, Cyrille, PIHLGREN BOSCH, Maria, CROASDALE-WOOD, Rebecca, PERRO, Mario, SRIVASTAVA, Ankita, DYSON, Michael, CARRETERO IGLESIA, Laura, PAIS, Daniela, ESTOPPEY, Carole, HALL, Olivia, DRAKE, Adam
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
Patent
ANTI-TLR4 ANTIBODIES AND USES THEREOF
FISCHER NICOLAS, KOSCO-VILBOIS MARIE, ROUSSEAU FRANCOIS, LOYAU JÉRÉMY, ELSON GREG
Year of Publication 30.03.2018
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Year of Publication 30.03.2018
Patent
ANTI-TLR4-ANTISTOFFER OG ANVENDELSER DERAF
FISCHER, Nicolas, LOYAU, Jérémy, KOSCO-VILBOIS, Marie, ELSON, Greg, ROUSSEAU, Francois
Year of Publication 18.12.2017
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Year of Publication 18.12.2017
Patent
ANTI-TLR4 ANTIBODIES AND USES THEREOF
FISCHER, Nicolas, LOYAU, Jérémy, KOSCO-VILBOIS, Marie, ELSON, Greg, ROUSSEAU, Francois
Year of Publication 01.11.2017
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Year of Publication 01.11.2017
Patent
ANTI-TLR4 ANTIBODIES AND USES THEREOF
KOSCO-VILBOIS, MARIE, ELSON, GREG, FISCHER, NICOLAS, LOYAU, JÉRÉMY, ROUSSEAU, FRANCOIS
Year of Publication 04.02.2015
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Year of Publication 04.02.2015
Patent
Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to Fcγ receptors: Fc-mediated avidity enhances the potency of an anti-TLR4 antibody
Loyau, Jérémy, Malinge, Pauline, Daubeuf, Bruno, Shang, Limin, Elson, Greg, Kosco-Vilbois, Marie, Fischer, Nicolas, Rousseau, François
Published in mAbs (02.11.2014)
Published in mAbs (02.11.2014)
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Report
Staphylococcus aureus Strains Isolated from Bloodstream Infections Changed Significantly in 2006
Mee-Marquet, Nathalie van der, Epinette, Christophe, Loyau, Jeremy, Arnault, Laurence, Domelier, Anne-Sophie, Losfelt, Barbara, Girard, Nicole, Quentin, Roland
Published in Journal of Clinical Microbiology (01.03.2007)
Published in Journal of Clinical Microbiology (01.03.2007)
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Journal Article
ANTIBODIES THAT BIND TO IL1RAP AND USES THEREOF
MACOIN, Julie, LOYAU, Jeremy, MONNEY, Thierry, DOUCEY, Marie-Agnes, CROSET, Amelie, LABANCA, Valentina, MBOW, Lamine
Year of Publication 03.10.2024
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Year of Publication 03.10.2024
Patent