Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
Kalkreuter, Edward, Bingham, Kyle S, Keeler, Aaron M, Lowell, Andrew N, Schmidt, Jennifer J, Sherman, David H, Williams, Gavin J
Published in Nature communications (13.04.2021)
Published in Nature communications (13.04.2021)
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Journal Article
Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and CH Functionalization
Lowell, Andrew N, DeMars, Matthew D, Slocum, Samuel T, Yu, Fengan, Anand, Krithika, Chemler, Joseph A, Korakavi, Nisha, Priessnitz, Jennifer K, Park, Sung Ryeol, Koch, Aaron A, Schultz, Pamela J, Sherman, David H
Published in Journal of the American Chemical Society (14.06.2017)
Published in Journal of the American Chemical Society (14.06.2017)
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Journal Article
Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida
Breiner-Goldstein, Elinor, Eyal, Zohar, Matzov, Donna, Halfon, Yehuda, Cimicata, Giuseppe, Baum, Moti, Rokney, Assaf, Ezernitchi, Analia V, Lowell, Andrew N, Schmidt, Jennifer J, Rozenberg, Haim, Zimmerman, Ella, Bashan, Anat, Valinsky, Lea, Anzai, Yojiro, Sherman, David H, Yonath, Ada
Published in Nucleic acids research (20.09.2021)
Published in Nucleic acids research (20.09.2021)
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Journal Article
Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering
Koryakina, Irina, Kasey, Christian, McArthur, John B, Lowell, Andrew N, Chemler, Joseph A, Li, Shasha, Hansen, Douglas A, Sherman, David H, Williams, Gavin J
Published in ACS chemical biology (20.01.2017)
Published in ACS chemical biology (20.01.2017)
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Journal Article
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis
Newmister, Sean A, Li, Shasha, Garcia-Borràs, Marc, Sanders, Jacob N, Yang, Song, Lowell, Andrew N, Yu, Fengan, Smith, Janet L, Williams, Robert M, Houk, K N, Sherman, David H
Published in Nature chemical biology (01.04.2018)
Published in Nature chemical biology (01.04.2018)
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Journal Article
A Concise Synthesis of the Naphthalene Portion of Purpuromycin
Lowell, Andrew N, Fennie, Michael W, Kozlowski, Marisa C
Published in Journal of organic chemistry (07.03.2008)
Published in Journal of organic chemistry (07.03.2008)
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Journal Article
Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images
Lowell, Andrew N, Qiao, Hui, Liu, Ting, Ishikawa, Takashi, Zhang, Hualei, Oriana, Sean, Wang, Miao, Ricciotti, Emanuela, FitzGerald, Garret A, Zhou, Rong, Yamakoshi, Yoko
Published in Bioconjugate chemistry (21.11.2012)
Published in Bioconjugate chemistry (21.11.2012)
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Journal Article
LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models
Yamakoshi, Yoko, Qiao, Hui, Lowell, Andrew N., Woods, Mark, Paulose, Betty, Nakao, Yuka, Zhang, Hualei, Liu, Ting, Lund-Katz, Sissel, Zhou, Rong
Published in Chemical communications (Cambridge, England) (01.01.2011)
Published in Chemical communications (Cambridge, England) (01.01.2011)
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Journal Article
Engineering the Substrate Specificity of a Modular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units
Kalkreuter, Edward, CroweTipton, Jared M, Lowell, Andrew N, Sherman, David H, Williams, Gavin J
Published in Journal of the American Chemical Society (06.02.2019)
Published in Journal of the American Chemical Society (06.02.2019)
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Journal Article
Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity
Gannett, Cole, Banks, Paige, Chuong, Christina, Weger-Lucarelli, James, Mevers, Emily, Lowell, Andrew N
Published in MedChemComm (26.04.2023)
Published in MedChemComm (26.04.2023)
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Journal Article
Hapalindole/Ambiguine Biogenesis Is Mediated by a Cope Rearrangement, C–C Bond-Forming Cascade
Li, Shasha, Lowell, Andrew N, Yu, Fengan, Raveh, Avi, Newmister, Sean A, Bair, Nathan, Schaub, Jeffrey M, Williams, Robert M, Sherman, David H
Published in Journal of the American Chemical Society (16.12.2015)
Published in Journal of the American Chemical Society (16.12.2015)
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Journal Article
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
Li, Shasha, Lowell, Andrew N, Newmister, Sean A, Yu, Fengan, Williams, Robert M, Sherman, David H
Published in Nature chemical biology (01.05.2017)
Published in Nature chemical biology (01.05.2017)
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Journal Article
Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-like Scenarios
Singh, Samrendra K., King, Kelsie, Gannett, Cole, Chuong, Christina, Joshi, Soumil Y., Plate, Charles, Farzeen, Parisa, Webb, Emily M., Kunche, Lakshmi Kumar, Weger-Lucarelli, James, Lowell, Andrew N., Brown, Anne M., Deshmukh, Sanket A.
Published in The journal of physical chemistry letters (26.10.2023)
Published in The journal of physical chemistry letters (26.10.2023)
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Journal Article
Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Koch, Aaron A., Schmidt, Jennifer J., Lowell, Andrew N., Hansen, Douglas A., Coburn, Katherine M., Chemler, Joseph A., Sherman, David H.
Published in Angewandte Chemie International Edition (03.08.2020)
Published in Angewandte Chemie International Edition (03.08.2020)
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Journal Article
Larger Substituents on Amide Cavitands Induce Bigger Cavities
Aroua, Safwan, Lowell, Andrew N, Ray, Ankita, Trapp, Nils, Schweizer, W. Bernd, Ebert, Marc-Olivier, Yamakoshi, Yoko
Published in Organic letters (04.01.2019)
Published in Organic letters (04.01.2019)
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Journal Article
Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids
Khatri, Yogan, Hohlman, Robert M, Mendoza, Johnny, Li, Shasha, Lowell, Andrew N, Asahara, Haruichi, Sherman, David H
Published in ACS synthetic biology (19.06.2020)
Published in ACS synthetic biology (19.06.2020)
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Journal Article
Structural Diversification of Hapalindole and Fischerindole Natural Products via Cascade Biocatalysis
Hohlman, Robert M, Newmister, Sean A, Sanders, Jacob N, Khatri, Yogan, Li, Shasha, Keramati, Nikki R, Lowell, Andrew N, Houk, K. N, Sherman, David H
Published in ACS catalysis (16.04.2021)
Published in ACS catalysis (16.04.2021)
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