Loading…
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Patil, Sandeep T, Zhang, Lu, Martenyi, Ferenc, Lowe, Stephen L, Jackson, Kimberley A, Andreev, Boris V, Avedisova, Alla S, Bardenstein, Leonid M, Gurovich, Issak Y, Morozova, Margarita A, Mosolov, Sergey N, Neznanov, Nikolai G, Reznik, Alexander M, Smulevich, Anatoly B, Tochilov, Vladimir A, Johnson, Bryan G, Monn, James A, Schoepp, Darryle D
Published in Nature medicine (01.09.2007)
Published in Nature medicine (01.09.2007)
Get full text
Journal Article
Loading…
Discovery and clinical translation of ceperognastat, an O‐GlcNAcase (OGA) inhibitor, for the treatment of Alzheimer's disease
Kielbasa, William, Goldsmith, Paul, Donnelly, Kevin B., Nuthall, Hugh N., Shcherbinin, Sergey, Fleisher, Adam S., Hendle, Jörg, DuBois, Susan L., Lowe, Stephen L., Zhang, Feiyu Fred, Woerly, Eric M., Dreyfus, Nicolas J.‐F., Evans, David, Gilmore, Jeremy, Mancini, Michele, Constantinescu, Cristian C., Gunn, Roger N., Russell, David S., Collins, Emily C., Brys, Miroslaw, Hutton, Michael L., Mergott, Dustin J.
Published in Alzheimer's & dementia : translational research & clinical interventions (01.10.2024)
Published in Alzheimer's & dementia : translational research & clinical interventions (01.10.2024)
Get full text
Journal Article
Loading…
Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
May, Patrick C., Dean, Robert A., Lowe, Stephen L., Martenyi, Ferenc, Sheehan, Scott M., Boggs, Leonard N., Monk, Scott A., Mathes, Brian M., Mergott, Dustin J., Watson, Brian M., Stout, Stephanie L., Timm, David E., Smith LaBell, Elizabeth, Gonzales, Celedon R., Nakano, Masako, Jhee, Stanford S., Yen, Mark, Ereshefsky, Larry, Lindstrom, Terry D., Calligaro, David O., Cocke, Patrick J., Greg Hall, D., Friedrich, Stuart, Citron, Martin, Audia, James E.
Published in The Journal of neuroscience (16.11.2011)
Published in The Journal of neuroscience (16.11.2011)
Get full text
Journal Article
Loading…
The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans
May, Patrick C., Willis, Brian A., Lowe, Stephen L., Dean, Robert A., Monk, Scott A., Cocke, Patrick J., Audia, James E., Boggs, Leonard N., Borders, Anthony R., Brier, Richard A., Calligaro, David O., Day, Theresa A., Ereshefsky, Larry, Erickson, Jon A., Gevorkyan, Hykop, Gonzales, Celedon R., James, Douglas E., Jhee, Stanford S., Komjathy, Steven F., Li, Linglin, Lindstrom, Terry D., Mathes, Brian M., Martényi, Ferenc, Sheehan, Scott M., Stout, Stephanie L., Timm, David E., Vaught, Grant M., Watson, Brian M., Winneroski, Leonard L., Yang, Zhixiang, Mergott, Dustin J.
Published in The Journal of neuroscience (21.01.2015)
Published in The Journal of neuroscience (21.01.2015)
Get full text
Journal Article
Loading…
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor
McKinzie, David L, Winneroski, Leonard L, Green, Steven J, Hembre, Erik J, Erickson, Jon A, Willis, Brian A, Monk, Scott A, Aluise, Christopher D, Baker, Thomas K, Lopez, Jose E, Hendle, Jörg, Beck, James P, Brier, Richard A, Boggs, Leonard N, Borders, Anthony R, Cocke, Patrick J, Garcia-Losada, Pablo, Lowe, Stephen L, Mathes, Brian M, May, Patrick C, Porter, Warren J, Stout, Stephanie L, Timm, David E, Watson, Brian M, Yang, Zhixiang, Mergott, Dustin J
Published in Journal of medicinal chemistry (24.06.2021)
Published in Journal of medicinal chemistry (24.06.2021)
Get full text
Journal Article
Loading…
Safety, tolerability, and pharmacokinetic evaluation of single- and multiple-ascending doses of a novel kappa opioid receptor antagonist LY2456302 and drug interaction with ethanol in healthy subjects
Lowe, Stephen L, Wong, Conrad J, Witcher, Jennifer, Gonzales, Celedon R, Dickinson, Gemma L, Bell, Robert L, Rorick-Kehn, Linda, Weller, MaryAnn, Stoltz, Randall R, Royalty, Jane, Tauscher-Wisniewski, Sitra
Published in Journal of clinical pharmacology (01.09.2014)
Published in Journal of clinical pharmacology (01.09.2014)
Get more information
Journal Article
Loading…
Theoretical UV Circular Dichroism of Aliphatic Cyclic Dipeptides
Carlson, Kristine L, Lowe, Stephen L, Hoffmann, Mark R, Thomasson, Kathryn A
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (23.06.2005)
Published in The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment, & general theory (23.06.2005)
Get full text
Journal Article
Loading…
Safety, Tolerability, and Pharmacokinetics of Zagotenemab in Participants with Symptomatic Alzheimer’s Disease: A Phase I Clinical Trial
Willis, Brian A., Lo, Albert C., Dage, Jeffrey L., Shcherbinin, Sergey, Chinchen, Louise, Andersen, Scott W., LaBell, Elizabeth S., Perahia, David G.S., Hauck, Paula M., Lowe, Stephen L.
Published in JAD reports (01.01.2023)
Published in JAD reports (01.01.2023)
Get full text
Journal Article
Loading…
Determining Pharmacological Selectivity of the Kappa Opioid Receptor Antagonist LY2456302 Using Pupillometry as a Translational Biomarker in Rat and Human
Rorick-Kehn, Linda M., Witcher, Jennifer W., Lowe, Stephen L., Gonzales, Celedon R., Weller, Mary Ann, Bell, Robert L., Hart, John C., Need, Anne B., McKinzie, Jamie H., Statnick, Michael A., Suico, Jeffrey G., McKinzie, David L., Tauscher-Wisniewski, Sitra, Mitch, Charles H., Stoltz, Randall R., Wong, Conrad J.
Published in The international journal of neuropsychopharmacology (01.02.2015)
Published in The international journal of neuropsychopharmacology (01.02.2015)
Get full text
Journal Article
Loading…
Brownian dynamics simulations of the interactions between lactate dehydrogenase (LDH) and G- or F-Actin. Part I: Muscle and heart homo-isoforms
Njabon, Eric N., Patouossa, Issofa, Carlson, Kristine L., Lowe, Stephen L., Forlemu, Neville Y., Thomasson, Kathryn A.
Published in Scientific African (01.09.2020)
Published in Scientific African (01.09.2020)
Get full text
Journal Article
Loading…
Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species
Willis, Brian A., Lowe, Stephen L., Monk, Scott A., Cocke, Patrick J., Aluise, Christopher D., Boggs, Leonard N., Borders, Anthony R., Brier, Richard A., Dean, Robert A., Green, Steven J., James, Douglas E., Jhee, Stanford S., Lin, Qun, Lo, Albert C., May, Patrick C., Watson, Brian M., Winneroski, Leonard L., Yang, Zhixiang, Zimmer, Jennifer A., McKinzie, David L., Mergott, Dustin J.
Published in JAD reports (01.01.2022)
Published in JAD reports (01.01.2022)
Get full text
Journal Article
Loading…
Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics
Lachno, D Richard, Emerson, Julie K, Vanderstichele, Hugo, Gonzales, Celedon, Martényi, Ferenc, Konrad, Robert J, Talbot, Jayne A, Lowe, Stephen L, Oefinger, Paul E, Dean, Robert A
Published in Journal of Alzheimer's disease (01.01.2012)
Published in Journal of Alzheimer's disease (01.01.2012)
Get more information
Journal Article
Loading…
Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
Banerjee, Sugato, Evanson, Janel, Harris, Erik, Lowe, Stephen L, Thomasson, Kathryn A, Porter, James E
Published in BMC pharmacology (15.06.2006)
Published in BMC pharmacology (15.06.2006)
Get full text
Journal Article
Loading…
SAFETY, PHARMACOKINETICS (PK), AND FLORBETAPIR F-18 POSITRON EMISSION TOMOGRAPHY (PET) AFTER MULTIPLE DOSE ADMINISTRATION OF LY3002813, A β-AMYLOID PLAQUE-SPECIFIC ANTIBODY, IN ALZHEIMER’S DISEASE (AD)
Irizarry, Michael C, Sims, John R, Lowe, Stephen L, Nakano, Masako, Hawdon, Anne, Willis, Brian A, Gonzales, Celedon, Liu, Peng, Fujimoto, Shino, Dean, Robert A, Konrad, Robert J, Shcherbinin, Sergey, Schwarz, Adam J, Mintun, Mark A, Devous, Michael D, DeMattos, Ronald B
Published in Alzheimer's & dementia (01.07.2016)
Published in Alzheimer's & dementia (01.07.2016)
Get full text
Journal Article
Loading…
Glycolytic Enzyme Interactions with Yeast and Skeletal Muscle F-Actin
Waingeh, Victor F., Gustafson, Carol D., Kozliak, Evguenii I., Lowe, Stephen L., Knull, Harvey R., Thomasson, Kathryn A.
Published in Biophysical journal (15.02.2006)
Published in Biophysical journal (15.02.2006)
Get full text
Journal Article
Loading…
Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants
Willis, Brian A, Zhang, Wei, Ayan-Oshodi, Mosun, Lowe, Stephen L, Annes, William F, Sirois, Paul J, Friedrich, Stuart, de la Peña, Amparo
Published in Journal of clinical pharmacology (01.06.2012)
Published in Journal of clinical pharmacology (01.06.2012)
Get more information
Journal Article
Loading…
The Effects on Metabolic Clearance when Administering a Potent CYP3A Autoinducer with the Prototypic CYP3A Inhibitor, Ketoconazole
Ayan-Oshodi, Mosun A., Willis, Brian A., Annes, William F., Lowe, Stephen L., Friedrich, Stuart, de la Peña, Amparo, Zhang, Wei, Brown, Thomas, Wise, Stephen D., Hall, Stephen D.
Published in Drug metabolism and disposition (01.10.2012)
Published in Drug metabolism and disposition (01.10.2012)
Get full text
Journal Article
Loading…
A COMPARISON OF IN VIVO POTENCY IN TWO BACE INHIBITORS AS DETERMINED IN HUMANS AND DOGS
Willis, Brian A, May, Patrick C, Monk, Scott A, Lowe, Stephen L, Friedrich, Stuart, Mergott, Dustin J, Boggs, Leonard, Gevorkyan, Hakop, Jhee, Stan, Dean, Robert A, Nakano, Masako, Gonzales, Celedon R
Published in Alzheimer's & dementia (01.07.2014)
Published in Alzheimer's & dementia (01.07.2014)
Get full text
Journal Article
Loading…
Adverse events in healthy subjects exposed to single and multiple doses of LY2140023 monohydrate: pooled results from 10 phase 1 studies
Ayan-Oshodi, Mosun, Wondmagegnehu, Eshetu T, Lowe, Stephen L, Kryzhanovskaya, Ludmila, Walker, Daniel J, Kinon, Bruce J
Published in Journal of clinical psychopharmacology (01.06.2012)
Published in Journal of clinical psychopharmacology (01.06.2012)
Get more information
Journal Article
Loading…
Cortisol response to individualised graded insulin infusions: a reproducible biomarker for CNS compounds inhibiting HPA activation
Chen, Christopher L. H., Willis, Brian A., Mooney, Louise, Ong, Guan Koon, Lim, Chay Ngee, Lowe, Stephen L., Tauscher‐Wisniewski, Sitra, Cutler Jr, Gordon B., Wiss, Stephen D.
Published in British journal of clinical pharmacology (01.12.2010)
Published in British journal of clinical pharmacology (01.12.2010)
Get full text
Journal Article