Major Developments in the Design of Inhibitors along the Kynurenine Pathway
Jacobs, Kelly R, Castellano-Gonzalez, Gloria, Guillemin, Gilles J, Lovejoy, David B
Published in Current medicinal chemistry (01.01.2017)
Published in Current medicinal chemistry (01.01.2017)
Get more information
Journal Article
Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer
Kovacevic, Zaklina, Chikhani, Sherin, Lovejoy, David B, Richardson, Des R
Published in Molecular pharmacology (01.10.2011)
Published in Molecular pharmacology (01.10.2011)
Get full text
Journal Article
Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau
Jacobs, Kelly R., Lim, Chai K., Blennow, Kaj, Zetterberg, Henrik, Chatterjee, Pratishtha, Martins, Ralph N., Brew, Bruce J., Guillemin, Gilles J., Lovejoy, David B.
Published in Neurobiology of aging (01.08.2019)
Published in Neurobiology of aging (01.08.2019)
Get full text
Journal Article
Brain co‐delivery of first‐line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy
Liu, Yanjie, Wang, Wendie, Zhang, Dongya, Sun, Yajing, Li, Fangzhou, Zheng, Meng, Lovejoy, David B., Zou, Yan, Shi, Bingyang
Published in Exploration (Beijing, China) (01.08.2022)
Published in Exploration (Beijing, China) (01.08.2022)
Get full text
Journal Article
Differential kynurenine pathway metabolism in highly metastatic aggressive breast cancer subtypes: beyond IDO1-induced immunosuppression
Heng, Benjamin, Bilgin, Ayse A, Lovejoy, David B, Tan, Vanessa X, Milioli, Heloisa H, Gluch, Laurence, Bustamante, Sonia, Sabaretnam, Tharani, Moscato, Pablo, Lim, Chai K, Guillemin, Gilles J
Published in Breast cancer research : BCR (27.10.2020)
Published in Breast cancer research : BCR (27.10.2020)
Get full text
Journal Article
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease
Chatterjee, Pratishtha, Zetterberg, Henrik, Goozee, Kathryn, Lim, Chai K, Jacobs, Kelly R, Ashton, Nicholas J, Hye, Abdul, Pedrini, Steve, Sohrabi, Hamid R, Shah, Tejal, Asih, Prita R, Dave, Preeti, Shen, Kaikai, Taddei, Kevin, Lovejoy, David B, Guillemin, Gilles J, Blennow, Kaj, Martins, Ralph N
Published in Journal of neuroinflammation (10.10.2019)
Published in Journal of neuroinflammation (10.10.2019)
Get full text
Journal Article
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action
Lui, Goldie Y L, Obeidy, Peyman, Ford, Samuel J, Tselepis, Chris, Sharp, Danae M, Jansson, Patric J, Kalinowski, Danuta S, Kovacevic, Zaklina, Lovejoy, David B, Richardson, Des R
Published in Molecular pharmacology (01.01.2013)
Published in Molecular pharmacology (01.01.2013)
Get full text
Journal Article
Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity
Richardson, Des R, Sharpe, Philip C, Lovejoy, David B, Senaratne, Dakshita, Kalinowski, Danuta S, Islam, Mohammad, Bernhardt, Paul V
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
Get full text
Journal Article
Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond
YU YU, WONG, Jacky, LOVEJOY, David B, KALINOWSKI, Danuta S, RICHARDSON, Des R
Published in Clinical cancer research (01.12.2006)
Published in Clinical cancer research (01.12.2006)
Get full text
Journal Article
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms
Castellano-Gonzalez, Gloria, Jacobs, Kelly R., Don, Emily, Cole, Nicholas J., Adams, Seray, Lim, Chai K., Lovejoy, David B., Guillemin, Gilles J.
Published in Neurotoxicity research (01.04.2019)
Published in Neurotoxicity research (01.04.2019)
Get full text
Journal Article
Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β
Cespedes, Marcela, Jacobs, Kelly R., Maruff, Paul, Rembach, Alan, Fowler, Christopher J., Trounson, Brett, Pertile, Kelly K., Rumble, Rebecca L., Rainey-Smithe, Stephanie R., Rowe, Christopher C., Villemagne, Victor L., Bourgeat, Pierrick, Lim, Chai K., Chatterjee, Pratishtha, Martins, Ralph N., Ittner, Arne, Masters, Colin L., Doecke, James D., Guillemin, Gilles J., Lovejoy, David B.
Published in Neurobiology of disease (01.09.2022)
Published in Neurobiology of disease (01.09.2022)
Get full text
Journal Article
Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity
Bernhardt, Paul V, Sharpe, Philip C, Islam, Mohammad, Lovejoy, David B, Kalinowski, Danuta S, Richardson, Des R
Published in Journal of medicinal chemistry (22.01.2009)
Published in Journal of medicinal chemistry (22.01.2009)
Get full text
Journal Article
Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo
Ford, SJ, Obeidy, P, Lovejoy, DB, Bedford, M, Nichols, L, Chadwick, C, Tucker, O, Lui, GYL, Kalinowski, DS, Jansson, PJ, Iqbal, TH, Alderson, D, Richardson, DR, Tselepis, C
Published in British journal of pharmacology (01.03.2013)
Published in British journal of pharmacology (01.03.2013)
Get full text
Journal Article
The medicinal chemistry of novel iron chelators for the treatment of cancer
Kovacevic, Zaklina, Kalinowski, Danuta S, Lovejoy, David B, Yu, Yu, Suryo Rahmanto, Yohan, Sharpe, Phillip C, Bernhardt, Paul V, Richardson, Des R
Published in Current topics in medicinal chemistry (01.03.2011)
Published in Current topics in medicinal chemistry (01.03.2011)
Get more information
Journal Article
Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity
Lim, Chai K, Essa, Musthafa M, de Paula Martins, Roberta, Lovejoy, David B, Bilgin, Ayse A, Waly, Mostafa I, Al-Farsi, Yahya M, Al-Sharbati, Marwan, Al-Shaffae, Mohammed A, Guillemin, Gilles J
Published in Autism research (01.06.2016)
Published in Autism research (01.06.2016)
Get more information
Journal Article
Design, Synthesis, and Characterization of Novel Iron Chelators: Structure−Activity Relationships of the 2-Benzoylpyridine Thiosemicarbazone Series and Their 3-Nitrobenzoyl Analogues as Potent Antitumor Agents
Kalinowski, Danuta S, Yu, Sharpe, Philip C, Islam, Mohammad, Liao, Yi-Tyng, Lovejoy, David B, Kumar, Naresh, Bernhardt, Paul V, Richardson, Des R
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article