Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds
Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E
Published in Chemical research in toxicology (15.10.2012)
Published in Chemical research in toxicology (15.10.2012)
Get full text
Journal Article
Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi
Elsby, Robert, Kitteringham, Neil R, Goldring, Christopher E, Lovatt, Cerys A, Chamberlain, Mark, Henderson, Colin J, Wolf, C Roland, Park, B Kevin
Published in The Journal of biological chemistry (20.06.2003)
Published in The Journal of biological chemistry (20.06.2003)
Get full text
Journal Article
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
Get full text
Journal Article
Determination of drug concentrations using dried blood spots: investigation of blood sampling and collection techniques in Crl:CD(SD) rats
Stokes, Alan H, Moose, Tammy A, Parry, Simon P, Barfield, Matthew, Lovatt, Cerys A, Dopson, Wesley J, Melich, David, Overvold, Carol R, Gade, Sonya D, Spooner, Neil
Published in Laboratory animals (London) (01.04.2011)
Published in Laboratory animals (London) (01.04.2011)
Get full text
Journal Article
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, Chris E. P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A, Randle, Laura E, Abdullah, Azman, Owen, Andrew, Liu, Xiaoping, Butler, Philip J, Williams, Dominic P, Metcalfe, Peter, Berens, Christian, Hillen, Wolfgang, Foster, Brian, Simpson, Alec, McLellan, Lesley, Park, B. Kevin
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Get full text
Journal Article
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Weaver, Richard J., Blomme, Eric A., Chadwick, Amy E., Copple, Ian M., Gerets, Helga H. J., Goldring, Christopher E., Guillouzo, Andre, Hewitt, Philip G., Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig, Juhila, Satu, Klingmüller, Ursula, Labbe, Gilles, Liguori, Michael J., Lovatt, Cerys A., Morgan, Paul, Naisbitt, Dean J., Pieters, Raymond H. H., Snoeys, Jan, van de Water, Bob, Williams, Dominic P., Park, B. Kevin
Published in Nature reviews. Drug discovery (01.02.2020)
Published in Nature reviews. Drug discovery (01.02.2020)
Get full text
Journal Article
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
Get full text
Journal Article
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Goldring, Chris E P, Kitteringham, Neil R, Jenkins, Rosalind, Lovatt, Cerys A
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Get full text
Published in American Journal of Physiology: Cell Physiology (01.01.2006)
Journal Article