An Innovative Phase I Clinical Study Demonstrates Inhibition of FLT3 Phosphorylation by SU11248 in Acute Myeloid Leukemia Patients
O'FARRELL, Anne-Marie, FORAN, James M, HEINRICH, Michael C, BERDEL, Wolfgang E, BELLO, Carlo, JACOBS, Mark, SCIGALLA, Paul, MANNING, William C, KELSEY, Stephen, CHERRINGTON, Julie M, FIEDLER, Walter, SERVE, Hubert, PAQUETTE, Ron L, COOPER, Maureen A, YUEN, Helene A, LOUIE, Sharianne G, KIM, Heidi, NICHOLAS, Susan
Published in Clinical cancer research (15.11.2003)
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Published in Clinical cancer research (15.11.2003)
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CHIR-258: A Potent Inhibitor of FLT3 Kinase in Experimental Tumor Xenograft Models of Human Acute Myelogenous Leukemia
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Published in Clinical cancer research (15.07.2005)
Published in Clinical cancer research (15.07.2005)
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Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non-Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit
KOEPPEN, Hartmut, WEI YU, LING FU, AN DO, PARAB, Vaishali, XIAOLING XIA, JANUARIO, Tom, LOUIE, Sharianne G, FILVAROFF, Ellen, SHAMES, David S, WISTUBA, Ignacio, LIPKIND, Marina, JIPING ZHA, HUANG, Jenny, LAZAROV, Mirella, RAMAKRISHNAN, Vanitha, AMLER, Lukas, PHAN, See-Chun, PATEL, Premal, PETERSON, Amy, YAUCH, Robert L, PANDITA, Ajay, PENUEL, Elicia, RANGELL, Linda, RAJA, Rajiv, MOHAN, Sankar, PATEL, Rajesh, DESAI, Rupal
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
Fiedler, Walter, Serve, Hubert, Döhner, Hartmut, Schwittay, Michael, Ottmann, Oliver G., O'Farrell, Anne-Marie, Bello, Carlo L., Allred, Randy, Manning, William C., Cherrington, Julie M., Louie, Sharianne G., Hong, Weiru, Brega, Nicoletta M., Massimini, Giorgio, Scigalla, Paul, Berdel, Wolfgang E., Hossfeld, Dieter K.
Published in Blood (01.02.2005)
Published in Blood (01.02.2005)
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In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
MENDEL, Dirk B, LAIRD, A. Douglas, MURRAY, Lesley J, CARVER, Jeremy, CHAN, Emily, MOSS, Katherine G, HAZNEDAR, Joshua Ö, SUKBUNTHERNG, Juthamas, BLAKE, Robert A, LI SUN, CHO TANG, MILLER, Todd, XIAOHUA XIN, SHIRAZIAN, Sheri, MCMAHON, Gerald, CHERRINGTON, Julie M, LOUIE, Sharianne G, CHRISTENSEN, James G, GUANGMIN LI, SCHRECK, Randall E, ABRAMS, Tinya J, NGAI, Theresa J, LEE, Leslie B
Published in Clinical cancer research (2003)
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Published in Clinical cancer research (2003)
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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
O'Farrell, Anne-Marie, Abrams, Tinya J., Yuen, Helene A., Ngai, Theresa J., Louie, Sharianne G., Yee, Kevin W.H., Wong, Lily M., Hong, Weiru, Lee, Leslie B., Town, Ajia, Smolich, Beverly D., Manning, William C., Murray, Lesley J., Heinrich, Michael C., Cherrington, Julie M.
Published in Blood (01.05.2003)
Published in Blood (01.05.2003)
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SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
Giles, Francis J., Stopeck, Alison T., Silverman, Lewis R., Lancet, Jeffrey E., Cooper, Maureen A., Hannah, Alison L., Cherrington, Julie M., O'Farrell, Anne-Marie, Yuen, Helene A., Louie, Sharianne G., Hong, Weiru, Cortes, Jorge E., Verstovsek, Srdan, Albitar, Maher, O'Brien, Susan M., Kantarjian, Hagop M., Karp, Judith E.
Published in Blood (01.08.2003)
Published in Blood (01.08.2003)
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Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia
O’Farrell, Anne-Marie, Yuen, Helene A, Smolich, Beverly, Hannah, Alison L, Louie, Sharianne G, Hong, Weiru, Stopeck, Alison T, Silverman, Lewis R, Lancet, Jeffrey E, Karp, Judith E, Albitar, Maher, Cherrington, Julie M, Giles, Francis J
Published in Leukemia research (01.07.2004)
Published in Leukemia research (01.07.2004)
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Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib plus or minus Onartuzumab in Advanced Non-Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit
Koeppen, Hartmut, Yu, Wei, Zha, Jiping, Pandita, Ajay, Penuel, Elicia, Rangell, Linda, Raja, Rajiv, Mohan, Sankar, Patel, Rajesh, Desai, Rupal, Fu, Ling, Do, An, Parab, Vaishali, Xia, Xiaoling, Januario, Tom, Louie, Sharianne G, Filvaroff, Ellen, Shames, David S, Wistuba, Ignacio, Lipkind, Marina, Huang, Jenny, Lazarov, Mirella, Ramakrishnan, Vanitha, Amler, Lukas, Phan, See-Chun, Patel, Premal, Peterson, Amy, Yauch, Robert L
Published in Clinical cancer research (01.09.2014)
Published in Clinical cancer research (01.09.2014)
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In Vivo Antitumor Activity of SU11248, a Novel Tyrosine Kinase Inhibitor Targeting Vascular Endothelial Growth Factor and Platelet-derived Growth Factor Receptors
Dirk B. Mendel, A. Douglas Laird, Xiaohua Xin, Sharianne G. Louie, James G. Christensen, Guangmin Li, Randall E. Schreck, Tinya J. Abrams, Theresa J. Ngai, Leslie B. Lee, Lesley J. Murray, Jeremy Carver, Emily Chan, Katherine G. Moss, Joshua Ö. Haznedar, Juthamas Sukbuntherng, Robert A. Blake, Li Sun, Cho Tang, Todd Miller, Sheri Shirazian, Gerald McMahon, Julie M. Cherrington
Published in Clinical cancer research (01.01.2003)
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Published in Clinical cancer research (01.01.2003)
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The Progesterone Receptor and Its Isoforms in Mammary Development
Shyamala, G., Louie, Sharianne G., Camarillo, Ignacio G., Talamantes, Frank
Published in Molecular Genetics and Metabolism (01.10.1999)
Published in Molecular Genetics and Metabolism (01.10.1999)
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Book Review
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SU6668 inhibits Flk-1/KDR and PDGFRbeta in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice
Laird, A Douglas, Christensen, Jmes G, Li, Guangmin, Carver, Jeremy, Smith, Kimberly, Xin, Xiaohua, Moss, Katherine G, Louie, Sharianne G, Mendel, Dirk B, Cherrington, Julie M
Published in The FASEB journal (01.05.2002)
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Published in The FASEB journal (01.05.2002)
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