Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (26.07.2016)
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Journal Article
Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site
Ghafoori, Seyed Mohammad, Petersen, Gayle F., Conrady, Deborah G., Calhoun, Brandy M., Stigliano, Matthew Z. Z., Baydo, Ruth O., Grice, Rena, Abendroth, Jan, Lorimer, Donald D., Edwards, Thomas E., Forwood, Jade K.
Published in Scientific reports (28.04.2023)
Published in Scientific reports (28.04.2023)
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Journal Article
Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1
Ghafoori, Seyed Mohammad, Robles, Alyssa M., Arada, Angelika M., Shirmast, Paniz, Dranow, David M., Mayclin, Stephen J., Lorimer, Donald D., Myler, Peter J., Edwards, Thomas E., Kuhn, Misty L., Forwood, Jade K.
Published in Scientific reports (04.05.2021)
Published in Scientific reports (04.05.2021)
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Journal Article
Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms
Moen, Spencer O., Edwards, Thomas E., Dranow, David M., Clifton, Matthew C., Sankaran, Banumathi, Van Voorhis, Wesley C., Sharma, Amit, Manoil, Colin, Staker, Bart L., Myler, Peter J., Lorimer, Donald D.
Published in Scientific reports (16.03.2017)
Published in Scientific reports (16.03.2017)
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Journal Article
A Structural Biology Approach Enables the Development of Antimicrobials Targeting Bacterial Immunophilins
BEGLEY, Darren W, FOX, David, BARNES, Steve R, MOEN, Spencer O, RAYMOND, Amy C, STACY, Robin, MYLER, Peter J, STAKER, Bart L, HARMER, Nicholas J, NORVILLE, Isobel H, HOLZGRABE, Ulrike, SARKAR-TYSON, Mitali, JENNER, Dominic, EDWARDS, Thomas E, LORIMER, Donald D, JULI, Christina, PIERCE, Phillip G, ABENDROTH, Jan, MURUTHI, Muigai, SAFFORD, Kris, ANDERSON, Vanessa, ATKINS, Kateri
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
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Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme
Kesari, Pooja, Deshmukh, Anuradha, Pahelkar, Nikhil, Suryawanshi, Abhishek B., Rathore, Ishan, Mishra, Vandana, Dupuis, John H., Xiao, Huogen, Gustchina, Alla, Abendroth, Jan, Labaied, Mehdi, Yada, Rickey Y., Wlodawer, Alexander, Edwards, Thomas E., Lorimer, Donald D., Bhaumik, Prasenjit
Published in Protein science (01.04.2022)
Published in Protein science (01.04.2022)
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Journal Article
Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Lowe, Martin A., Cardenas, Alvaro, Valentin, Jean-Pierre, Zhu, Zhaoning, Abendroth, Jan, Castro, Jose L., Class, Reiner, Delaunois, Annie, Fleurance, Renaud, Gerets, Helga, Gryshkova, Vitalina, King, Lloyd, Lorimer, Donald D., MacCoss, Malcolm, Rowley, Julian H., Rosseels, Marie-Luce, Royer, Leandro, Taylor, Richard D., Wong, Melanie, Zaccheo, Oliver, Chavan, Vishal P., Ghule, Gokul A., Tapkir, Bapusaheb K., Burrows, Jeremy N., Duffey, Maëlle, Rottmann, Matthias, Wittlin, Sergio, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Striepen, Josefine, Fairhurst, Kate J., Yeo, Tomas, Fidock, David A., Cowman, Alan F., Favuzza, Paola, Crespo-Fernandez, Benigno, Gamo, Francisco Javier, Goldberg, Daniel E., Soldati-Favre, Dominique, Laleu, Benoît, de Haro, Teresa
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
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Journal Article
Structure of acid deoxyribonuclease
Varela-Ramirez, Armando, Abendroth, Jan, Mejia, Adrian A, Phan, Isabelle Q, Lorimer, Donald D, Edwards, Thomas E, Aguilera, Renato J
Published in Nucleic acids research (02.06.2017)
Published in Nucleic acids research (02.06.2017)
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Journal Article
Toward a structome of Acinetobacter baumannii drug targets
Tillery, Logan M., Barrett, Kayleigh F., Dranow, David M., Craig, Justin, Shek, Roger, Chun, Ian, Barrett, Lynn K., Phan, Isabelle Q., Subramanian, Sandhya, Abendroth, Jan, Lorimer, Donald D., Edwards, Thomas E., Van Voorhis, Wesley C.
Published in Protein science (01.03.2020)
Published in Protein science (01.03.2020)
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Journal Article
Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major
Iwasaki, Jua, Lorimer, Donald D., Vivoli-Vega, Mirella, Kibble, Emily A., Peacock, Christopher S., Abendroth, Jan, Mayclin, Stephen J., Dranow, David M., Pierce, Phillip G., Fox, David, Lewis, Maria, Bzdyl, Nicole M., Kristensen, Sofie S., Inglis, Timothy J. J., Kahler, Charlene M., Bond, Charles S., Hasenkopf, Anja, Seufert, Florian, Schmitz, Jens, Marshall, Laura E., Scott, Andrew E., Norville, Isobel H., Myler, Peter J., Holzgrabe, Ulrike, Harmer, Nicholas J., Sarkar-Tyson, Mitali
Published in Journal of antimicrobial chemotherapy (29.05.2022)
Published in Journal of antimicrobial chemotherapy (29.05.2022)
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Journal Article
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W, Osterhout, Bram, Tran, Nathan L, Xu, Lily, Young, Ryan M, Craig, Justin, Chun, Ian, Dranow, David M, Abendroth, Jan, Delker, Silvia L, Davies, Douglas R, Mayclin, Stephen J, Calhoun, Brandy, Bolejack, Madison J, Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D, Myler, Peter J, Edwards, Thomas E, Kyle, Dennis E, Rice, Christopher A, Morris, James C, Leahy, James W, Manetsch, Roman, Barrett, Lynn K, Smith, Craig L, Van Voorhis, Wesley C
Published in PloS one (24.03.2021)
Published in PloS one (24.03.2021)
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Journal Article
Structural and functional characterization of FabG4 from Mycolicibacterium smegmatis
Ran, Xinping, Parikh, Prashit, Abendroth, Jan, Arakaki, Tracy L, Clifton, Matthew C, Edwards, Thomas E, Lorimer, Donald D, Mayclin, Stephen, Staker, Bart L, Myler, Peter, McLaughlin, Krystle J
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2024)
Published in Acta crystallographica. Section F, Structural biology communications (01.04.2024)
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Structures of glyceraldehyde 3‐phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis
Barrett, Kayleigh F., Dranow, David M., Phan, Isabelle Q., Michaels, Samantha A., Shaheen, Shareef, Navaluna, Edelmar D., Craig, Justin K., Tillery, Logan M., Choi, Ryan, Edwards, Thomas E., Conrady, Deborah G., Abendroth, Jan, Horanyi, Peter S., Lorimer, Donald D., Van Voorhis, Wesley C., Zhang, Zhongsheng, Barrett, Lynn K., Subramanian, Sandhya, Staker, Bart, Fan, Erkang, Myler, Peter J., Soge, Olusegun O., Hybiske, Kevin, Ojo, Kayode K.
Published in Protein science (01.03.2020)
Published in Protein science (01.03.2020)
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Journal Article
Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products
Sullivan, Amy H., Dranow, David M., Horanyi, Peter S., Lorimer, Donald D., Edwards, Thomas E., Abendroth, Jan
Published in Scientific reports (13.03.2019)
Published in Scientific reports (13.03.2019)
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Journal Article
Characterization of a family I inorganic pyrophosphatase from Legionella pneumophila Philadelphia 1
Moorefield, Julia, Konuk, Yagmur, Norman, Jordan O, Abendroth, Jan, Edwards, Thomas E, Lorimer, Donald D, Mayclin, Stephen J, Staker, Bart L, Craig, Justin K, Barett, Kayleigh F, Barrett, Lynn K, Van Voorhis, Wesley C, Myler, Peter J, McLaughlin, Krystle J
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2023)
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2023)
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Journal Article
Crystal structure and biophysical characterization of IspD from Burkholderia thailandensis and Mycobacterium paratuberculosis
Pierce, Phillip G, Hartnett, Brian E, Laughlin, Tosha M, Blain, Joy M, Mayclin, Stephen J, Bolejack, Madison J, Myers, Janette B, Higgins, Tate W, Dranow, David M, Sullivan, Amy, Lorimer, Donald D, Edwards, Thomas E, Hagen, Timothy J, Horn, James R, Myler, Peter J
Published in Acta crystallographica. Section F, Structural biology communications (01.02.2024)
Published in Acta crystallographica. Section F, Structural biology communications (01.02.2024)
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Journal Article
Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors
Haft, Daniel H., Pierce, Phillip G., Mayclin, Stephen J., Sullivan, Amy, Gardberg, Anna S., Abendroth, Jan, Begley, Darren W., Phan, Isabelle Q., Staker, Bart L., Myler, Peter J., Marathias, Vasilios M., Lorimer, Donald D., Edwards, Thomas E.
Published in Scientific reports (25.01.2017)
Published in Scientific reports (25.01.2017)
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Journal Article
Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Plewe, Michael B., Sokolova, Nadezda, Gantla, Vidyasagar Reddy, Brown, Eric R., Naik, Shibani, Fetsko, Alexandra, Lorimer, Donald D., Dranow, David M., Smutney, Hayden, Bullen, Jameson, Sidhu, Rana, Master, Arshil, Wang, Junru, Kallel, E. Adam, Zhang, Lihong, Kalveram, Birte, Freiberg, Alexander N., Henkel, Greg, McCormack, Ken
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Crystal structure of acetoacetyl‐CoA reductase from Rickettsia felis
Rodarte, Justas V., Abendroth, Jan, Edwards, Thomas E., Lorimer, Donald D., Staker, Bart L., Zhang, Sunny, Myler, Peter J., McLaughlin, Krystle J.
Published in Acta crystallographica. Section F, Structural biology communications (01.02.2021)
Published in Acta crystallographica. Section F, Structural biology communications (01.02.2021)
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